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View article: Plant-based secondary metabolites as natural remedies: a comprehensive review on terpenes and their therapeutic applications
Plant-based secondary metabolites as natural remedies: a comprehensive review on terpenes and their therapeutic applications Open
Terpenes are among the most diverse kinds of natural products because of their remarkable chemical variety. Numerous biological characteristics of terpenoids have been documented, including their antibacterial, antifungal, antiviral, antih…
View article: Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET
Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET Open
Leishmania donovani, the causative agent of visceral leishmaniasis (VL), is prevalent in Brazil, East Africa, and India. The treatment options for VL are currently limited and are often associated with adverse effects, highlighting the urg…
View article: Identification and Evaluation of IGF1R and Its Associated Proteins as Targets and Design of Novel Inhibitors for Cancer Therapy
Identification and Evaluation of IGF1R and Its Associated Proteins as Targets and Design of Novel Inhibitors for Cancer Therapy Open
The insulin‐like growth factor 1 receptor (IGF1R) is a crucial receptor tyrosine kinase involved in cellular growth, survival, and metabolism. Abnormal overexpression and activation are common in various cancers and contribute to tumor dev…
View article: Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach
Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach Open
Despite recent breakthroughs in diagnosis and treatment, cancer remains a worldwide health challenge with high mortality. Autophagy plays a major role in the progression and development. Starving cancer cells obtain nutrients through the u…
View article: Sustainable synthesis of bakuchiol-mediated gold nanoparticles for drug delivery against bacterial strains and tumor microenvironments, and its in silico target proteins identification
Sustainable synthesis of bakuchiol-mediated gold nanoparticles for drug delivery against bacterial strains and tumor microenvironments, and its in silico target proteins identification Open
Introduction The sustained synthesis of gold nanoparticles (GNPs) has gained significant attention in biomedical applications. In this study, we explored the antibacterial and anticancer potential of bakuchiol-mediated gold nanoparticles (…
View article: Drug repositioning to discover novel ornithine decarboxylase inhibitors against visceral leishmaniasis
Drug repositioning to discover novel ornithine decarboxylase inhibitors against visceral leishmaniasis Open
Visceral leishmaniasis (VL) is caused by Leishmania donovani ( Ld ), and most cases occur in Brazil, East Africa, and India. The treatment for VL is limited and has many adverse effects. The development of safer and more efficacious drugs …
View article: RAGE Inhibitors for Targeted Therapy of Cancer: A Comprehensive Review
RAGE Inhibitors for Targeted Therapy of Cancer: A Comprehensive Review Open
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin family that is overexpressed in several cancers. RAGE is highly expressed in the lung, and its expression increases proportionally at the site of inf…