Tad H. Koch
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View article: TMIC-14. A novel IDO1 PROTAC decreases immunosuppressive extracellular IDO1 levels
TMIC-14. A novel IDO1 PROTAC decreases immunosuppressive extracellular IDO1 levels Open
BACKGROUND Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme expressed in >90% of patient-resected glioblastoma (GBM). IDO1 expression is inversely correlated with GBM patient survival. Extracellular IDO1 contributes t…
View article: ZMoveMent-1: Effect of a resistance and aerobic training intervention on quality of life, fitness, immunological parameters, and oncological outcome in patients with prostate cancer
ZMoveMent-1: Effect of a resistance and aerobic training intervention on quality of life, fitness, immunological parameters, and oncological outcome in patients with prostate cancer Open
View article: Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205
Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205 Open
This phase I trial evaluated the IDO1 enzyme inhibitor, BMS-986205, with radiation (RT) and nivolumab treatment in newly diagnosed patients with GBM IDHwt. Cohort A received RT + nivolumab with escalating BMS-986205 doses in MGMT unmethyla…
View article: Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)
Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC) Open
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive protein that inhibits antitumor immunity through both tryptophan metabolism and nonenzymatic functions. Drugs targeting IDO1 enzyme activity have failed to improve the overall su…
View article: Kinetic inductance coupling for circuit QED with spins
Kinetic inductance coupling for circuit QED with spins Open
In contrast to the commonly used qubit resonator transverse coupling via the $σ_{xy}$-degree of freedom, longitudinal coupling through $σ_z$ presents a tantalizing alternative: it does not hybridize the modes, eliminating Purcell decay, an…
View article: Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)
Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC) Open
Indoleamine 2,3-dioxygenase 1 (IDO1) is a potently immunosuppressive protein that inhibits antitumor immunity through both tryptophan metabolism and non-enzymatic functions. Pharmacological therapies targeting IDO1 enzyme activity have gen…
View article: Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine
Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine Open
Doxazolidine (Doxaz) is a functionally distinct formaldehyde conjugate of doxorubicin (Dox) that induces cancer cell death in Dox-sensitive and resistant cells. Pentyl PABC-Doxaz (PPD) is a prodrug of Doxaz that is activated by carboxylest…
View article: Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence
Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence Open
Colloidal drug aggregates have been a nuisance in drug screening, yet, because they inherently comprise drug-rich particles, they may be useful in vivo if issues of stability can be addressed. As the first step toward answering this questi…
View article: Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations Open
While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. …
View article: CCDC 1421706: Experimental Crystal Structure Determination
CCDC 1421706: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …