Tadashi Iida
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View article: Meflin is a druggable target using antibody-drug conjugates in progressive osteosarcoma
Meflin is a druggable target using antibody-drug conjugates in progressive osteosarcoma Open
View article: Delayed Bleeding After Endoscopic Ultrasound‐guided Hepaticogastrostomy due to Pseudoaneurysm Rupture in a Patient Who Underwent Plastic Stent Placement: A Case Report
Delayed Bleeding After Endoscopic Ultrasound‐guided Hepaticogastrostomy due to Pseudoaneurysm Rupture in a Patient Who Underwent Plastic Stent Placement: A Case Report Open
Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is a useful alternative treatment for endoscopic retrograde cholangiopancreatography (ERCP) failure. However, serious complications sometimes occur. Bleeding is an early complicati…
View article: Polyethyleneimine-Assisted Fabrication of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Tamibarotene (Am80) for Meflin Expression Upregulation
Polyethyleneimine-Assisted Fabrication of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Tamibarotene (Am80) for Meflin Expression Upregulation Open
Tamibarotene (Am80) is a promising anti-tumor drug that induces the expression of Meflin (a glycosylphosphatidyl inositol-anchored protein) in cancer-associated fibroblasts, thereby improving the tumor microenvironment. However, Am80, whic…
View article: Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1
Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1 Open
Nerves have been shown to regulate cancer progression. However, a clear demonstration of a role for axon guidance molecules in pancreatic tumorigenesis, innervation, and metastasis has been lacking. Using murine Kras G12D -mutant pancreati…
View article: New Endoscopic Strategy for Ampullary Tumor and Superficial Nonampullary Duodenal Epithelial Tumor Extending Into Papillary Area
New Endoscopic Strategy for Ampullary Tumor and Superficial Nonampullary Duodenal Epithelial Tumor Extending Into Papillary Area Open
Background and Study Aim Endoscopic papillectomy (EP) is widely performed for avoiding high‐risk surgeries. However, recurrence rates are high, and lateral extension is a risk for recurrence. With endoscopic submucosal dissection (ESD), ev…
View article: Perilesional branch duct dilation as a hallmark MRCP feature for differentiating high-grade PanIN from low-grade PanIN
Perilesional branch duct dilation as a hallmark MRCP feature for differentiating high-grade PanIN from low-grade PanIN Open
Perilesional BPD dilation on MRCP is a primary imaging feature for differentiating HG-PanIN, characterized by substantial interobserver agreement. While PPA on MRI is another important independent predictor, its lower interobserver agreeme…
View article: Ampullary tumors exhibit increased Fusobacterium in both the tumor surface and surrounding duodenal mucosa during carcinoma progression
Ampullary tumors exhibit increased Fusobacterium in both the tumor surface and surrounding duodenal mucosa during carcinoma progression Open
View article: Clinical features and long‐term prognosis of type 1 autoimmune pancreatitis based on the location of bile duct lesions
Clinical features and long‐term prognosis of type 1 autoimmune pancreatitis based on the location of bile duct lesions Open
Background/Purpose Type 1 autoimmune pancreatitis (AIP) frequently involves biliary lesions and poses diagnostic and therapeutic challenges. We aimed to evaluate the clinical features and long‐term prognosis of type 1 AIP with a focus on t…
View article: A Novel Clip Device for Safer and Faster Suturing in Endoscopic Papillectomy: A Retrospective Study of 241 Procedures
A Novel Clip Device for Safer and Faster Suturing in Endoscopic Papillectomy: A Retrospective Study of 241 Procedures Open
Background and Aim Endoscopic papillectomy (EP) is a minimally invasive treatment for ampullary neoplasms. However, traditional endoscopic clips used for hemostasis and suturing during EP are often difficult to manipulate because of limita…
View article: Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen
Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen Open
In pancreatic hypervascular masses, it is often difficult to differentiate pancreatic neuroendocrine neoplasm (PanNEN) and intrapancreatic accessory spleen (IPAS) before surgery because of their similar features, such as a round shape and …
View article: Stiff extracellular matrix activates the transcription factor ATF5 to promote the proliferation of cancer cells
Stiff extracellular matrix activates the transcription factor ATF5 to promote the proliferation of cancer cells Open
View article: Data from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Data from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor microenvironment, have each been shown to directly promote gastrointestinal cancers. However, it remains unknown whether these cells interact with each other to regula…
View article: Supplementary Tables S1 and S2 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Supplementary Tables S1 and S2 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Supplementary Table S1: List of differentially expressed genes in RNA-seq from norepinephrine- or vehicle-treated AKP tumor organoids. Supplementary Table S2: Gene set enrichment analyses using RNA-seq data from norepinephrine- or vehicle-…
View article: Supplementary Figures S1-10 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Supplementary Figures S1-10 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Supplementary Figure S1 supports Figure 1 and shows stromal NGF expression and innervation in human colorectal cancer tissues. Supplementary Figure S2 supports Figure 1 and shows stromal NGF expression and innervation in mouse colorectal c…
View article: Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue
Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue Open
Brown adipose tissue (BAT) is an energy‐consuming organ, and its functional dysregulation contributes to the development of metabolic diseases and obesity. BAT function is regulated by the sympathetic nervous system but declines with age, …
View article: Factors associated with misdiagnosis of preoperative endoscopic ultrasound in patients with pancreatic cystic neoplasms undergoing surgical resection
Factors associated with misdiagnosis of preoperative endoscopic ultrasound in patients with pancreatic cystic neoplasms undergoing surgical resection Open
View article: Hepatic Artery Aneurysm Rupture After Double‐Balloon Endoscopy in Biliary Atresia
Hepatic Artery Aneurysm Rupture After Double‐Balloon Endoscopy in Biliary Atresia Open
View article: A newly proposed endoscopic score system to evaluate the entire small bowel and predict the prognosis in Crohn's disease.
A newly proposed endoscopic score system to evaluate the entire small bowel and predict the prognosis in Crohn's disease. Open
Small bowel stenosis in patients with Crohn's disease leads to abdominal symptoms and can affect prognosis. The Simple Endoscopic Score for Crohn's Disease for the large bowel has been applied to the small bowel; however, stenosis scoring …
View article: 1396 Alteration in the tumor microenvironment during the process of becoming immune checkpoint blockade therapy resistant
1396 Alteration in the tumor microenvironment during the process of becoming immune checkpoint blockade therapy resistant Open
View article: Endoscopic Papillectomy for Ampullary Gangliocytic Paraganglioma: A Case Series and Literature Review
Endoscopic Papillectomy for Ampullary Gangliocytic Paraganglioma: A Case Series and Literature Review Open
Objective Gangliocytic paraganglioma (GP) significantly affects patients' quality of life. However, studies on endoscopic papillectomy (EP) for ampullary GP are limited. We therefore evaluated the safety and efficacy of EP for treating amp…
View article: Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor microenvironment, have each been shown to directly promote gastrointestinal cancers. However, it remains unknown whether these cells interact with each other to regula…
View article: Predictors of the efficacy of vedolizumab in patients with ulcerative colitis.
Predictors of the efficacy of vedolizumab in patients with ulcerative colitis. Open
Vedolizumab is a treatment option for ulcerative colitis but data on predictors of treatment response remain insufficient to establish personalized treatment strategies. We aimed to investigate the real-world effectiveness of vedolizumab i…
View article: Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade
Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade Open
Background The proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to immune checkpoint blockade (ICB) therapy. However, it has remained a challenge to develop ther…
View article: Correction: Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions
Correction: Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions Open
View article: Endoscopic ultrasound-guided drainage using a forward-viewing echoendoscope for peripancreatic fluid collection after Child resection
Endoscopic ultrasound-guided drainage using a forward-viewing echoendoscope for peripancreatic fluid collection after Child resection Open
Peripancreatic fluid collection (PFC) due to pancreatic leakage is one of the significant complications arising following pancreatic surgery. Although endoscopic ultrasound (EUS)-guided drainage is less invasive than other methods in treat…
View article: Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function
Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function Open
Numerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments varies largely. Non-responsiveness to biological therapies is associated with interleukin (IL)-18 gene …
View article: Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions
Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions Open
This article provides an extensive review of the advancements and future perspectives related to endoscopic ultrasound-guided tissue acquisition (EUS-TA) for the diagnosis of solid pancreatic lesions (SPLs). EUS-TA, including fine-needle a…
View article: Current status of and future issues related to endoscopic papillectomy.
Current status of and future issues related to endoscopic papillectomy. Open
Endoscopic papillectomy is widely performed to treat duodenal papillary tumors, particularly at high-volume centers. It is indicated for adenomas without intraductal extension of the bile or pancreatic ducts. However, despite numerous repo…
View article: Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas
Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas Open
Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofi…
View article: Clinical characteristics of Dieulafoy’s lesion in the small bowel diagnosed and treated by double-balloon endoscopy
Clinical characteristics of Dieulafoy’s lesion in the small bowel diagnosed and treated by double-balloon endoscopy Open
Background Obscure gastrointestinal bleeding refers to bleeding for which the source cannot be ascertained even through balloon-assisted endoscopy. In certain instances, Dieulafoy’s lesion in the small bowel is presumed to be the underlyin…