Tadashi Sato
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View article: Effectiveness of educational reinstruction on patient satisfaction and inhaler technique in Japanese patients with stable chronic obstructive pulmonary disease: A prospective, open-label, randomized controlled trial
Effectiveness of educational reinstruction on patient satisfaction and inhaler technique in Japanese patients with stable chronic obstructive pulmonary disease: A prospective, open-label, randomized controlled trial Open
Reinstruction improved inhaler technique without changing satisfaction, with apparently greater benefit earlier in device use; however, timing inferences are exploratory. Early, appropriately timed education may maximize technique gains an…
View article: Identification of an early-heading mutant in Indonesian native rice cultivar: ‘Gemdjah Beton-10’
Identification of an early-heading mutant in Indonesian native rice cultivar: ‘Gemdjah Beton-10’ Open
View article: I. The Association of Heated Tobacco Products and COPD
I. The Association of Heated Tobacco Products and COPD Open
View article: Impact of the COVID-19 pandemic on COPD exacerbations in Japanese patients: a retrospective study
Impact of the COVID-19 pandemic on COPD exacerbations in Japanese patients: a retrospective study Open
Various infection control measures implemented during the coronavirus disease (COVID-19) pandemic have reduced the number of respiratory infections, which are the most common cause of chronic obstructive pulmonary disease (COPD) exacerbati…
View article: Higher detectability of gastric cancer after <i>Helicobacter pylori</i> eradication in texture and color enhancement imaging mode 2 in screening endoscopy
Higher detectability of gastric cancer after <i>Helicobacter pylori</i> eradication in texture and color enhancement imaging mode 2 in screening endoscopy Open
Objectives The utility of texture and color enhancement imaging (TXI) in detecting gastric cancer (GC) has been investigated. However, few reports exist on TXI mode2 (TXI2) used for detecting GC; this study investigated the efficacy of TXI…
View article: Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting
Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting Open
Introduction. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlat…
View article: Serum Levels of N- and C-ERC/Mesothelin and Clinicopathological Factors in Mesothelioma Patients and Those without Mesothelioma
Serum Levels of N- and C-ERC/Mesothelin and Clinicopathological Factors in Mesothelioma Patients and Those without Mesothelioma Open
Although both markers are good indicators of treatment-responses in individual patients with mesothelioma, only C-ERC reflected the amount of ERC/Mesothelin in mesothelioma among multiple patients, possibly because N-ERC was influenced by …
View article: Carcinoembryonic antigen levels in pancreatic juice are associated with histological subtypes of intraductal papillary mucinous neoplasm of the pancreas
Carcinoembryonic antigen levels in pancreatic juice are associated with histological subtypes of intraductal papillary mucinous neoplasm of the pancreas Open
Background The present study aimed to examine the correlation between preoperative carcinoembryonic antigen levels in pancreatic juice (PJ‐CEA) and the histological subtype of intraductal papillary mucinous neoplasm (IPMN). Methods We enro…
View article: Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways
Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways Open
View article: Long-term safety of Prolastin®-C, an alpha1-proteinase inhibitor, in Japanese patients with alpha1-antitrypsin deficiency
Long-term safety of Prolastin®-C, an alpha1-proteinase inhibitor, in Japanese patients with alpha1-antitrypsin deficiency Open
GOV: NCT02870348; JAPIC CTI: JapicCTI-163194.
View article: Complemental Diagnosis of IgG4-Related Pancreaticobiliary Diseases by Multiple Hypoechoic Lesions in the Submandibular Glands
Complemental Diagnosis of IgG4-Related Pancreaticobiliary Diseases by Multiple Hypoechoic Lesions in the Submandibular Glands Open
The diagnosis of autoimmune pancreatitis (AIP) and immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) may require a somewhat invasive pathological examination and steroid responsiveness. This retrospective study assessed the comple…
View article: Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs
Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs Open
Pulmonary emphysema is predominantly caused by chronic exposure to cigarette smoke (CS). Novel tobacco substitutes, such as heated tobacco products (HTPs), have emerged as healthier alternatives to cigarettes. IQOS, the most popular HTP in…
View article: Protocol for assessing senescence-associated lung pathologies in mice
Protocol for assessing senescence-associated lung pathologies in mice Open
View article: P7‐3: Exposure to the heated tobacco product IQOS generates apoptosis‐mediated pulmonary emphysema in murine lungs
P7‐3: Exposure to the heated tobacco product IQOS generates apoptosis‐mediated pulmonary emphysema in murine lungs Open
View article: P7‐44: Involvement of airway hyperresponsiveness in the therapy for COPD
P7‐44: Involvement of airway hyperresponsiveness in the therapy for COPD Open
Method: The study retrospectively recruited patients hospitalized due to HFrEF in a tertiary medical center.The clinical outcomes including length of hospital stay, mortality and readmission episodes were examined and traced for 5 years.Th…
View article: P4‐16: Swallowing dysfunction in patients with chronic respiratory disease
P4‐16: Swallowing dysfunction in patients with chronic respiratory disease Open
tomography (HRCT) of the thorax showed diffuse illdefined ground glass centrilobular densities scattered in both lung fields with no zonal predominance.A diagnosis of hydrochlorofluorocarbons (HCFC) induced acute pneumonitis was made.He wa…
View article: P7‐46: Airflow obstruction on spirometry in patients undergoing surgery using general anesthesia
P7‐46: Airflow obstruction on spirometry in patients undergoing surgery using general anesthesia Open
Aims and Objectives: This retrospective clinical study was designed to examine how AHR develops in patients with COPD who have no symptom and no past history of asthma, and to determine whether AHR affects response to inhaled glucocorticos…
View article: Role of magnifying endoscopy with narrow‐band imaging in the diagnosis of noninvasive gastric neoplasia
Role of magnifying endoscopy with narrow‐band imaging in the diagnosis of noninvasive gastric neoplasia Open
Background and Aim There are no globally approved, distinguishing criteria enabling the classification of gastric adenomas and intramucosal carcinomas for differential diagnosis of noninvasive neoplasia (NIN). Methods Next‐generation seque…
View article: Clinical significance of genetic alterations in endoscopically obtained pancreatic cancer specimens
Clinical significance of genetic alterations in endoscopically obtained pancreatic cancer specimens Open
Although comprehensive gene analyses of pancreatic cancer provide new knowledge on molecular mechanisms, the usefulness and possibility of the analyses in routinely available clinical samples remain unclear. We assessed the possibility and…
View article: Altered serum levels of proteins involved in beta‐amyloid clearance in the aftermath of the Kumamoto magnitude 7.3 earthquake
Altered serum levels of proteins involved in beta‐amyloid clearance in the aftermath of the Kumamoto magnitude 7.3 earthquake Open
Background Our previous studies revealed that apoA‐I, transthyretin, and complement component 3 (C3) in serum were associated with cognitive decline, and that atrophy of atrophy of the medial temporal structures was associated with decreas…
View article: Hermansky-Pudlak syndrome-associated pneumothorax with rapid progression of respiratory failure: a case report
Hermansky-Pudlak syndrome-associated pneumothorax with rapid progression of respiratory failure: a case report Open
Background Hermansky-Pudlak syndrome (HPS) is an extremely rare disease with pulmonary fibrosis (PF), oculocutaneous albinism, induced platelet dysfunction, and granulomatous colitis. Although patients with HPS-associated PF (HPS-PF) often…
View article: <p>Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway</p>
Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway Open
These findings suggest that tranilast inhibits pulmonary fibrosis by suppressing TGFβ/SMAD2-mediated ECM protein production, presenting tranilast as a promising and novel anti-fibrotic agent for the treatment of IPF.
View article: Fractionated small cell‐free <scp>DNA</scp> increases possibility to detect cancer‐related gene mutations in advanced colorectal cancer
Fractionated small cell‐free <span>DNA</span> increases possibility to detect cancer‐related gene mutations in advanced colorectal cancer Open
Background and Aim Liquid biopsy is a method that can efficiently detect tumor genetic abnormalities from body fluids such as blood and urine. Detection sensitivity and the available number of mutations in cell‐free DNA (cfDNA) are limited…
View article: Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8
Long-term outcome after surgery in a patient with intestinal Behçet’s disease complicated by myelodysplastic syndrome and trisomy 8 Open
Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of i…
View article: Form-Vessel Classification of Cholangioscopy Findings to Diagnose Biliary Tract Carcinoma’s Superficial Spread
Form-Vessel Classification of Cholangioscopy Findings to Diagnose Biliary Tract Carcinoma’s Superficial Spread Open
We aimed to evaluate a newly developed peroral cholangioscopy (POCS) classification system by comparing classified lesions with histological and genetic findings. We analyzed 30 biopsied specimens from 11 patients with biliary tract cancer…
View article: p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction
p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction Open
Senescent cells accumulate in tissues during aging or pathological settings. The semi-genetic or pharmacological targeting of senescent cells revealed that cellular senescence underlies many aspects of the aging-associated phenotype and di…
View article: Diffusion-weighted image improves detectability of magnetic resonance cholangiopancreatography for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm
Diffusion-weighted image improves detectability of magnetic resonance cholangiopancreatography for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm Open
The present study is aimed to clarify the utility of magnetic resonance cholangiopancreatography (MRCP) and the additional value of diffusion-weighted imaging (DWI) in diagnosing pancreatic ductal adenocarcinoma (PDAC) concomitant with int…
View article: Ablation of <i>Arf</i>-expressing cells ameliorates cigarette smoke-induced lung dysfunction in mice
Ablation of <i>Arf</i>-expressing cells ameliorates cigarette smoke-induced lung dysfunction in mice Open
Senescent cells accumulate in tissues during aging or pathological settings. The semi-genetic or pharmacological targeting of senescent cells revealed that cellular senescence underlies many aspects of the aging-associated phenotype and di…
View article: P1‐249: REDUCED LEVELS OF PROTEINS INVOLVED IN Aβ CLEARANCE IN SERUM FOLLOWED BY ATROPHY OF THE MEDIAL TEMPORAL STRUCTURES IN THE AFTERMATH OF THE EARTHQUAKE
P1‐249: REDUCED LEVELS OF PROTEINS INVOLVED IN Aβ CLEARANCE IN SERUM FOLLOWED BY ATROPHY OF THE MEDIAL TEMPORAL STRUCTURES IN THE AFTERMATH OF THE EARTHQUAKE Open
Increased risk of dementia was observed in the aftermath of disaster like earthquake and tsunami, however, there is no study of biomarker for postdisaster cognitive decline. The 2016 Kumamoto Earthquake, which was featured twice strong ear…
View article: Genetic alterations related to endoscopic treatment of colorectal tumors
Genetic alterations related to endoscopic treatment of colorectal tumors Open
Background and Aim Genetic indicators of endoscopic resection for colorectal carcinoma remain inconclusive. This study analyzed genetic changes in early colorectal tumors that could inform decisions for endoscopic procedures. Methods A tot…