Tadeusz Osadnik
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View article: SCORE2 charts assign a different risk category than the underlying model in a large portion of Polish primary care patients
SCORE2 charts assign a different risk category than the underlying model in a large portion of Polish primary care patients Open
Aims This study aims to compare the estimates provided by the SCORE2/SCORE2-OP charts with the estimates obtained by using SCORE2 and SCORE2-OP risk model equations. Methods and results Patients were recruited from 16 major Polish administ…
View article: Correction to “Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)” [The Lancet Regional Health – Europe 49 (2025) 101182]
Correction to “Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)” [The Lancet Regional Health – Europe 49 (2025) 101182] Open
[This corrects the article DOI: 10.1016/j.lanepe.2024.101182.].
View article: Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)
Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015) Open
Polish Lipid Association, College of Family Physician in Poland, Valeant in Poland.
View article: Telomere length across the spectrum of metabolic health – an analysis from the LIPIDOGEN2015 study
Telomere length across the spectrum of metabolic health – an analysis from the LIPIDOGEN2015 study Open
Introduction Background: Telomere length is a cellular aging marker and correlates with various cardiovascular disease (CVD) risk factors. The current study assessed the association between obesity, metabolic syndrome (MetS), and telomere …
View article: Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study
Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study Open
View article: Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS) - study design and methodology.
Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS) - study design and methodology. Open
Introduction Classical risk factors such as hypertension, hypercholesterolemia, pre-diabetes, diabetes and obesity can predict adverse cardiovascular events, but they are less prognostic in patients age <60 years. Polygenic risk scores (PR…
View article: Ceruloplasmin and Lipofuscin Serum Concentrations Are Associated with Presence of Hypertrophic Cardiomyopathy
Ceruloplasmin and Lipofuscin Serum Concentrations Are Associated with Presence of Hypertrophic Cardiomyopathy Open
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and cells’ ability to neutralize them by antioxidant systems. The role of oxidative stress in hypertrophic cardiomyopathy (HCM) is not ful…
View article: The Critical Role of Community Pharmacists in Blood Pressure Monitoring
The Critical Role of Community Pharmacists in Blood Pressure Monitoring Open
Arterial hypertension is the most important modifiable risk factor for cardiovascular morbidity and mortality. In some countries, pharmacists' patient-centered approach has become a common practice, and their role in supporting the managem…
View article: ERRATUM: Genetic testing for inherited cardiovascular diseases. A position statement of the Polish Cardiac Society endorsed by Polish Society of Human Genetics and Cardiovascular Patient Communities
ERRATUM: Genetic testing for inherited cardiovascular diseases. A position statement of the Polish Cardiac Society endorsed by Polish Society of Human Genetics and Cardiovascular Patient Communities Open
According to the latest guidelines of European and American medical societies, genetic testing (GT) is essential in cardiovascular diseases for establishing diagnosis, predicting prognosis, enabling initiation of disease-modifying therapy,…
View article: Rola badań genetycznych w kardiologii
Rola badań genetycznych w kardiologii Open
Badania genetyczne odgrywają coraz większą rolę w kardiologii. Schorzenia kardiologiczne o podłożu genetycznym, do których zaliczamy m.in kardiomiopatie, kanałopatie czy dziedziczne tętniaki i rozwarstwienia aorty, są główną przyczyną nagł…
View article: Phenotypes of Polish primary care patients using hierarchical clustering: Exploring the risk of mortality in the <scp>LIPIDOGEN2015</scp> study cohort
Phenotypes of Polish primary care patients using hierarchical clustering: Exploring the risk of mortality in the <span>LIPIDOGEN2015</span> study cohort Open
Background Comorbidities in primary care do not occur in isolation but tend to cluster together causing various clinically complex phenotypes. This study aimed to distinguish phenotype clusters and identify the risks of all‐cause mortality…
View article: The Impact of Haplotypes of the FTO Gene, Lifestyle, and Dietary Patterns on BMI and Metabolic Syndrome in Polish Young Adult Men
The Impact of Haplotypes of the FTO Gene, Lifestyle, and Dietary Patterns on BMI and Metabolic Syndrome in Polish Young Adult Men Open
Background: Variants in fat mass and the obesity-associated protein (FTO) gene have long been recognized as the most significant genetic predictors of body fat mass and obesity. Nevertheless, despite the overall evidence, there are conflic…
View article: Genetic testing for inherited cardiovascular diseases. A position statement of the Polish Cardiac Society endorsed by Polish Society of Human Genetics and Cardiovascular Patient Communities
Genetic testing for inherited cardiovascular diseases. A position statement of the Polish Cardiac Society endorsed by Polish Society of Human Genetics and Cardiovascular Patient Communities Open
According to the latest guidelines of European and American medical societies, genetic testing (GT) is essential in cardiovascular diseases for establishing diagnosis, predicting prognosis, enabling initiation of disease-modifying therapy,…
View article: Association between Lp(a) and T2D: a Mendelian randomization study
Association between Lp(a) and T2D: a Mendelian randomization study Open
Introduction Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed. Me…
View article: "LC Risk Score" - development and evaluation of a scale for assessing the risk of developing long COVID
"LC Risk Score" - development and evaluation of a scale for assessing the risk of developing long COVID Open
Introduction Objective: To create a valuable practical tool for evaluating the risk of LC development. Material and methods 1150 patients from the Polish STOP-COVID registry (PoLoCOV study) were used to develop the risk score. The patients…
View article: May Measurement Month 2021: an analysis of blood pressure screening results from Poland
May Measurement Month 2021: an analysis of blood pressure screening results from Poland Open
May Measurement Month 2021 (MMM21) is the fourth edition of the global initiative in Poland initiated by the International Society of Hypertension (ISH) and aimed at raising awareness of hypertension and the need for blood pressure (BP) sc…
View article: Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels
Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels Open
Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and a specific apolipoprotein(a). The blood concentration of Lp(a) is approximately 90% genetically determined, and the main genetic factor determining Lp(a) lev…
View article: Association of body mass index and long-term mortality in patients from nationwide LIPIDOGRAM 2004–2015 cohort studies: no obesity paradox?
Association of body mass index and long-term mortality in patients from nationwide LIPIDOGRAM 2004–2015 cohort studies: no obesity paradox? Open
View article: Genetically determined lipoprotein(a) levels do not cause an increased risk of preeclampsia - a two-sample Mendelian randomization study
Genetically determined lipoprotein(a) levels do not cause an increased risk of preeclampsia - a two-sample Mendelian randomization study Open
Introduction High blood levels of lipoprotein(a) [Lp(a)] were suggested to increase the risk of preeclampsia. Because excessive coagulation is involved in preeclampsia and Lp(a) is a known pro-coagulative protein, the hypothesis that Lp(a)…
View article: Development and validation of risk score for patients in primary care setting in Poland
Development and validation of risk score for patients in primary care setting in Poland Open
Background Suitable, optimal risk prediction in primary care is still a large challenge. Current tools enable the creation of risk scales based on data for specific populations, which can be a large support to recognized risk scales used i…
View article: Lipoprotein(a) is not a causal factor for the development of diabetes - a two-sample Mendelian randomization study
Lipoprotein(a) is not a causal factor for the development of diabetes - a two-sample Mendelian randomization study Open
Introduction The association between lipoprotein(a) [Lp(a)] and coronary artery disease is well known. Nevertheless, because physiological function of Lp(a) is not well understood, it is not clear what sort of adverse effects therapies aim…
View article: Intensive Statin Therapy Versus Upfront Combination Therapy of Statin and Ezetimibe in Patients With Acute Coronary Syndrome: A Propensity Score Matching Analysis Based on the PL‐ACS Data
Intensive Statin Therapy Versus Upfront Combination Therapy of Statin and Ezetimibe in Patients With Acute Coronary Syndrome: A Propensity Score Matching Analysis Based on the PL‐ACS Data Open
Background We aimed to compare statin monotherapy and upfront combination therapy of statin and ezetimibe in patients with acute coronary syndromes (ACSs). Methods and Results The study included consecutive patients with ACS included in th…
View article: Impact of vitamin D receptor polymorphisms in selected metabolic disorders
Impact of vitamin D receptor polymorphisms in selected metabolic disorders Open
Purpose of review Vitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last m…
View article: Genetyka w wybranych chorobach neurologicznych u dzieci - od rozpoznania do leczenia
Genetyka w wybranych chorobach neurologicznych u dzieci - od rozpoznania do leczenia Open
View article: Metabolic syndrome is associated with similar long-term prognosis in those living with and without obesity: an analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004–2015 studies
Metabolic syndrome is associated with similar long-term prognosis in those living with and without obesity: an analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004–2015 studies Open
Aims We aimed to evaluate the association between metabolic syndrome (MetS) and long-term all-cause mortality. Methods and results The LIPIDOGRAM studies were carried out in the primary care in Poland in 2004, 2006, and 2015. MetS was diag…
View article: Intensive Statin Therapy Versus Upfront Combination Therapy of Statin &nbsp;And Ezetimibe in Acute Coronary Syndrome Patients. A Propensity Score Matching Analysis Based on the PL-ACS Registry Data
Intensive Statin Therapy Versus Upfront Combination Therapy of Statin And Ezetimibe in Acute Coronary Syndrome Patients. A Propensity Score Matching Analysis Based on the PL-ACS Registry Data Open
View article: LDL levels and long-term all-cause mortality in patients from nationwide LIPIDOGRAM 2004–2015 cohort studies
LDL levels and long-term all-cause mortality in patients from nationwide LIPIDOGRAM 2004–2015 cohort studies Open
Background Data from multiple randomized clinical trials show that lowering LDL cholesterol with statins is associated with significant reduction of outcomes both in primary and secondary prevention. Despite this some epidemiological studi…
View article: Relationship of obesity to mortality in 47,399 patients from nationwide LIPIDOGRAM 2004–2015 cohort studies
Relationship of obesity to mortality in 47,399 patients from nationwide LIPIDOGRAM 2004–2015 cohort studies Open
Background Evidence suggests that obesity may be associated with lower mortality rates in various cohorts of patients (obesity paradox). One possible explanation is unmeasured confounding factors induced by selection bias (collider stratif…
View article: Worldwide comparative efficacy of nutraceuticals on lipid profile. an updated systematic review and network meta-analysis
Worldwide comparative efficacy of nutraceuticals on lipid profile. an updated systematic review and network meta-analysis Open
Introduction In case of patients without indications to statin therapy, those being close to the target and especially with statin intolerance, nutraceuticals might be an additional option of hypercholesterolemia therapy. Despite a large n…
View article: Lean metabolic syndrome is associated with similar long-term prognosis as metabolic syndrome in overweight/obese patients. Analysis 47,399 Patients from nationwide LIPIDOGRAM 2004–2015 cohort studies
Lean metabolic syndrome is associated with similar long-term prognosis as metabolic syndrome in overweight/obese patients. Analysis 47,399 Patients from nationwide LIPIDOGRAM 2004–2015 cohort studies Open
Background Obesity was once though as an indispensable component of metabolic syndrome. Therefore, there a lot of definitions of metabolic syndrome with only few not including obesity as a criterion. The necessity of the obesity criterion …