Tae Hyung Won
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View article: Dietary fiber and microbiota-derived bile acids regulate type 2 immune response and metabolic homeostasis 3598
Dietary fiber and microbiota-derived bile acids regulate type 2 immune response and metabolic homeostasis 3598 Open
Description Diet alters both the composition and metabolic output of the intestinal microbiota, which has a major impact on the nature of immune responses. However, most microbiota-derived metabolites, their regulation by diet, and their i…
View article: Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation Open
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines and neuropeptides. However, their regulation by diet and microbiota-derived signals remains unclear. We show t…
View article: Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi
Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi Open
The genomes of many filamentous fungi, such as Aspergillus spp., include diverse biosynthetic gene clusters of unknown function. We previously showed that low copper levels upregulate a gene cluster that includes crmA , encoding a putative…
View article: Dual-purpose isocyanides produced by <i>Aspergillus fumigatus</i> contribute to cellular copper sufficiency and exhibit antimicrobial activity
Dual-purpose isocyanides produced by <i>Aspergillus fumigatus</i> contribute to cellular copper sufficiency and exhibit antimicrobial activity Open
Significance Metal homeostasis is an integral part of metabolism for any organism. A vast array of natural products are already known to mediate iron homeostasis in fungi and bacteria; however, unlike their bacterial counterparts, to date,…
View article: Dual-purpose isocyanides produced by<i>Aspergillus fumigatus</i>contribute to cellular copper sufficiency and exhibit antimicrobial activity
Dual-purpose isocyanides produced by<i>Aspergillus fumigatus</i>contribute to cellular copper sufficiency and exhibit antimicrobial activity Open
The maintenance of sufficient but non-toxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well-established role for iron homeostasis; however, no copper-binding analogs h…
View article: Isocadiolides A–H: Polybrominated Aromatics from a <i>Synoicum</i> sp. Ascidian
Isocadiolides A–H: Polybrominated Aromatics from a <i>Synoicum</i> sp. Ascidian Open
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohyd…
View article: Self‐Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase‐Cleavable Linker
Self‐Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase‐Cleavable Linker Open
Tumor heterogeneity is associated with the therapeutic failures of targeted therapies. To overcome such heterogeneity, a novel targeted therapy is proposed that could kill tumor populations with diverse phenotypes by delivering nonselectiv…
View article: Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus
Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus Open
Microbial secondary metabolites, including isocyanide moieties, have been extensively mined for their repertoire of bioactive properties. Although the first naturally occurring isocyanide (xanthocillin) was isolated from the fungus Penicil…
View article: Manzamine Alkaloids from an <i>Acanthostrongylophora</i> sp. Sponge
Manzamine Alkaloids from an <i>Acanthostrongylophora</i> sp. Sponge Open
Five new manzamine alkaloids (1-5) and new salt forms of two known manzamines (6 and 7), along with seven known compounds (8-14) of the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis …
View article: Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (<i>Panax ginseng</i>) Using UPLC-QToF-MS
Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (<i>Panax ginseng</i>) Using UPLC-QToF-MS Open
Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discriminatio…