Tae‐Gyu Lim
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View article: A Botanical Mixture (NWG11-02) of <i>Elaeagnus angustifolia</i> L. (oleaster) and <i>Sophora japonica</i> L. Fruit Extract Alleviates Monoiodoacetate-Induced Osteoarthritis in Rats
A Botanical Mixture (NWG11-02) of <i>Elaeagnus angustifolia</i> L. (oleaster) and <i>Sophora japonica</i> L. Fruit Extract Alleviates Monoiodoacetate-Induced Osteoarthritis in Rats Open
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial inflammation, and impaired joint function. This study investigated the therapeutic potential of a botanical mixture, N…
View article: Oral Administration of Edible Snail Extract Powder Prevents <scp>UVB</scp> ‐Induced Skin Damage
Oral Administration of Edible Snail Extract Powder Prevents <span>UVB</span> ‐Induced Skin Damage Open
Edible snail extract powder, which is known to hydrate and help heal skin, was evaluated to see if it could protect against skin damage from UVB via oral administration in an SKH‐1 hairless mouse model. Over a period of 117 days, mice were…
View article: Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in <scp>SKH</scp> ‐1 Hairless Mice
Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in <span>SKH</span> ‐1 Hairless Mice Open
SKH‐1 hairless mice were used as the in vivo model in this study to evaluate the efficacy of oral snail extract powder (SEP) on skin hydration and barrier enhancement. The skin serves as a primary barrier against external stimuli and plays…
View article: Cutaneous UVB Irradiation Alters Gut Microbiota Independently of Skin Inflammation in SKH-1 Hairless Mice
Cutaneous UVB Irradiation Alters Gut Microbiota Independently of Skin Inflammation in SKH-1 Hairless Mice Open
This study investigates the impact of chronic ultraviolet B (UVB) exposure on gut microbiota composition and skin inflammation. Mice were subjected to a 12-week regimen of low-dose UVB irradiation designed to mimic mild photoaging. Althoug…
View article: Vine Tea Extract (VTE) Inhibits High-Fat Diet-Induced Adiposity: Evidence of VTE’s Anti-Obesity Effects In Vitro and In Vivo
Vine Tea Extract (VTE) Inhibits High-Fat Diet-Induced Adiposity: Evidence of VTE’s Anti-Obesity Effects In Vitro and In Vivo Open
This study focused on evaluating the anti-obesity effects of an extract from Ampelopsis grossedentata (Hand.-Mazz.) W. T. Wang, also known as vine tea, in mature adipocytes and high-fat diet-induced obese mice. Vine tea extract (VTE) effec…
View article: Giant <i>Centella asiatica</i>, a novel cultivar rich in madecassoside and asiaticoside, suppresses α‑melanocyte‑stimulating hormone‑induced melanogenesis through MC1R binding
Giant <i>Centella asiatica</i>, a novel cultivar rich in madecassoside and asiaticoside, suppresses α‑melanocyte‑stimulating hormone‑induced melanogenesis through MC1R binding Open
The present study investigated the anti‑melanogenesis effects of Giant Centella asiatica (GCA), a new cultivator of Centella asiatica (CA) cataloged by the Korea Forest Service in 2022, and compared its efficacy with that of traditional CA…
View article: Structure-based virtual screening of natural compounds in preventing skin senescence: The role of epigallocatechin gallate in protein kinase C alpha-specific inhibition against UV-induced photoaging
Structure-based virtual screening of natural compounds in preventing skin senescence: The role of epigallocatechin gallate in protein kinase C alpha-specific inhibition against UV-induced photoaging Open
This study combines high-throughput screening and virtual molecular docking to identify natural compounds targeting PKC in skin aging. Go 6983, a PKC inhibitor, showed potent suppression of MMP-1 transcription. EGCG was one of the candidat…
View article: Anti-Melanogenic Effects of a Polysaccharide Isolated from Undaria pinnatifida Sporophyll Extracts
Anti-Melanogenic Effects of a Polysaccharide Isolated from Undaria pinnatifida Sporophyll Extracts Open
Undaria pinnatifida is a temperate brown alga known to exert free radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of U. pinnatifida sporophyll extracts (UPEs) in α-melanocyte-stim…
View article: Skin Improvement Effects of Ultrasound-Enzyme-Treated Collagen Peptide Extracts from Flatfish (Paralichthys olivaceus) Skin in an In Vitro Model
Skin Improvement Effects of Ultrasound-Enzyme-Treated Collagen Peptide Extracts from Flatfish (Paralichthys olivaceus) Skin in an In Vitro Model Open
Collagen is considered to be an intercellular adhesive that prevents tissue stretching or damage. It is widely utilized in cosmetic skin solutions, drug delivery, vitreous substitutions, 3D cell cultures, and surgery. In this study, we rep…
View article: Anti-Obesity Properties of Blackberries Fermented with L. plantarum JBMI F5 via Suppression of Adipogenesis Signaling Mechanisms
Anti-Obesity Properties of Blackberries Fermented with L. plantarum JBMI F5 via Suppression of Adipogenesis Signaling Mechanisms Open
Blackberries (Rubus fruticosus), which are known to include a variety of bioactive substances, have been extensively studied for their antioxidant properties. Blackberries possess multiple health beneficial effects, including anti-inflamma…
View article: Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics
Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics Open
Psoriasis is a chronic autoimmune inflammatory skin disorder that affects approximately 2–3% of the global population due to significant genetic predisposition. It is characterized by an uncontrolled growth and differentiation of keratinoc…
View article: Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice
Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice Open
The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fa…
View article: Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in a High-Fat Diet-Induced Obese Mice
Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in a High-Fat Diet-Induced Obese Mice Open
This study aimed to investigate the effect of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for a duration of 12 weeks. PGA-K administration reduced the increase in body weight, epididym…
View article: The Antimelanogenic Activity of the Extract of Heukharang Lettuce (Lactuca sativa L.) Leaf
The Antimelanogenic Activity of the Extract of Heukharang Lettuce (Lactuca sativa L.) Leaf Open
Heukharang (Lactuca sativa L.), the artificially developed lettuce cultivar for enhancement of lactucin content, exhibits antioxidant activities and sleep-promoting effects. However, potential of Heukharang as a raw material for the skin-w…
View article: Porcine Placenta Peptide Inhibits UVB-Induced Skin Wrinkle Formation and Dehydration: Insights into MAPK Signaling Pathways from In Vitro and In Vivo Studies
Porcine Placenta Peptide Inhibits UVB-Induced Skin Wrinkle Formation and Dehydration: Insights into MAPK Signaling Pathways from In Vitro and In Vivo Studies Open
Excessive exposure to ultraviolet (UV) radiation from sunlight accelerates skin aging, leading to various clinical manifestations such as wrinkles, dryness, and loss of elasticity. This study investigated the protective effects of porcine …
View article: Water Extract of Capsella bursa-pastoris Mitigates Doxorubicin-Induced Cardiotoxicity by Upregulating Antioxidant Enzymes
Water Extract of Capsella bursa-pastoris Mitigates Doxorubicin-Induced Cardiotoxicity by Upregulating Antioxidant Enzymes Open
Doxorubicin (DOX), an effective chemotherapeutic drug, causes cardiotoxicity in a cumulative and dose-dependent manner. The aim of this study is to investigate the effects of hot-water extract of Capsella bursa-pastoris (CBW) on DOX-induce…
View article: Antimelanogenic potential of brewer's spent grain extract through modulation of the MAPK/MITF axis
Antimelanogenic potential of brewer's spent grain extract through modulation of the MAPK/MITF axis Open
Beer brewing produces >39 million tons of brewer's spent grain (BSG) per year worldwide. Although BSG is rich in protein, fiber, and phytochemicals, it is mainly used as livestock feed, and some is discarded. In this study, we attempted to…
View article: Ultrasound-assisted pumpkin tendril extracts inhibits melanogenesis by suppressing the CREB/MITF signaling pathway in B16F10 melanoma cells, zebrafish, and a human skin model
Ultrasound-assisted pumpkin tendril extracts inhibits melanogenesis by suppressing the CREB/MITF signaling pathway in B16F10 melanoma cells, zebrafish, and a human skin model Open
Agricultural byproducts are intermediate products generated during food processing and contain functional ingredients that are suitable for use in the green circular economy. This study aimed to demonstrate the skin-whitening effect of pum…
View article: Krill oil inhibited adipogenic differentiation by inducing the nuclear Nrf2 expression and the <scp>AMPK</scp> activity
Krill oil inhibited adipogenic differentiation by inducing the nuclear Nrf2 expression and the <span>AMPK</span> activity Open
The current study investigated the antiadipogenic mechanism of krill oil from the 3T3‐L1 adipocytes. The krill oil adhered to the criteria as a food standard by showing 50.8% of the total phospholipid, 5.27% myristic acid, and 1.63% linole…
View article: Particulate matter-induced skin inflammation is suppressed by polyphenol-enriched dietary supplement via inhibition of the AhR/ARNT signaling pathway
Particulate matter-induced skin inflammation is suppressed by polyphenol-enriched dietary supplement via inhibition of the AhR/ARNT signaling pathway Open
Environmental factors that cause skin diseases cause an inflammatory response and cause various diseases. In this study, the ability of polyphenol-enriched dietary supplement (Zeropollution, ZP), a mixture of four types of natural extracts…
View article: Supplemental Figure 1 from The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth
Supplemental Figure 1 from The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth Open
6,7,4'-THIF does not bind to FKBP or cyclophilin A. The interaction between 6,7,4'-THIF and FKBP or cyclophilin A was confirmed using 6,7,4'-THIF-Sepharose 4B beads. 6,7,4'-THIF-Sepharose 4B beads were incubated with each cell lysate overn…
View article: Data from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin
Data from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin Open
The Wnt pathway is a promising therapeutic and preventive target in various human cancers. The transcriptional complex of β-catenin–T-cell factor (Tcf), a key mediator of canonical Wnt signaling, has been implicated in human colon cancer d…
View article: Supplementary Methods and Figure Legend from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin
Supplementary Methods and Figure Legend from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin Open
PDF file - 127K
View article: Supplementary Figure Legends from Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2
Supplementary Figure Legends from Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2 Open
PDF file - 178KB
View article: Data from The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth
Data from The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth Open
Intake of soy isoflavones is inversely associated with the risk of esophageal cancer. Numerous experimental results have supported the anticancer activity of soy isoflavones. This study aimed to determine the anti-esophageal cancer activit…
View article: Supplementary Figure 1 from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin
Supplementary Figure 1 from Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin Open
PDF file - 366K, Aseculetin suppresses the proliferation of HCT116, HT15 and DLD1 colon cancer cells.