Taejun Wang
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View article: Increased nicotinamide adenine dinucleotide pool promotes colon cancer progression by suppressing reactive oxygen species level
Increased nicotinamide adenine dinucleotide pool promotes colon cancer progression by suppressing reactive oxygen species level Open
Nicotinamide adenine dinucleotide ( NAD ) exists in an oxidized form (NAD + ) and a reduced form (NADH). NAD + plays crucial roles in cancer metabolism, including in cellular signaling, energy production and redox regulation. However, it r…
View article: Two-photon microscopy of Paneth cells in the small intestine of live mice
Two-photon microscopy of Paneth cells in the small intestine of live mice Open
View article: Three-photon tissue imaging using moxifloxacin
Three-photon tissue imaging using moxifloxacin Open
Moxifloxacin is an antibiotic used in clinics and has recently been used as a clinically compatible cell-labeling agent for two-photon (2P) imaging. Although 2P imaging with moxifloxacin labeling visualized cells inside tissues using enhan…
View article: Tumor Imaging: Colorectal Cancer Diagnosis Using Enzyme‐Sensitive Ratiometric Fluorescence Dye and Antibody–Quantum Dot Conjugates for Multiplexed Detection (Adv. Funct. Mater. 4/2018)
Tumor Imaging: Colorectal Cancer Diagnosis Using Enzyme‐Sensitive Ratiometric Fluorescence Dye and Antibody–Quantum Dot Conjugates for Multiplexed Detection (Adv. Funct. Mater. 4/2018) Open
Two imaging probes can be co-used for colonoscopic diagnosis: a fluorescent probe that ratiometrically switches between two colors in response to λ-glutamyltranspeptidase activity and an antibodyquantum dot probe. As shown by Ki Hean Kim, …
View article: Two‐Photon In Vivo Imaging with Porous Silicon Nanoparticles
Two‐Photon In Vivo Imaging with Porous Silicon Nanoparticles Open
A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near‐infrared (NIR) emitters that can also be excited with NIR radiat…
View article: Brain tumor delineation enhanced by moxifloxacin-based two-photon/CARS combined microscopy
Brain tumor delineation enhanced by moxifloxacin-based two-photon/CARS combined microscopy Open
Delineating brain tumor margin is critical for maximizing tumor removal while sparing adjacent normal tissue for better clinical outcome. We describe the use of moxifloxacin-based two-photon (TP)/coherent anti-Stokes Raman scattering (CARS…
View article: In vivo longitudinal visualization of bone marrow engraftment process in mouse calvaria using two-photon microscopy
In vivo longitudinal visualization of bone marrow engraftment process in mouse calvaria using two-photon microscopy Open
Intravital microscopy of mouse calvarial bone marrow (BM) is a powerful method for studying hematopoietic stem cells (HSCs) and the BM microenvironment at the cellular level. However, the current method used to access the mouse calvaria al…
View article: Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth
Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth Open
In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractio…
View article: Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging Open
Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenou…
View article: Synthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging
Synthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging Open
Near-infrared (NIR) fluorophores attract increasing attention as a molecular marker (or probe) for in vivo and in vitro biological fluorescence imaging. Three types of new NIR fluorescent conjugated oligoelectrolytes (COEs: Q-FlTBTTFl, Q-F…
View article: In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy
In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy Open
View article: Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle
Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle Open
View article: In vivo longitudinal cellular imaging of small intestine by side-view endomicroscopy
In vivo longitudinal cellular imaging of small intestine by side-view endomicroscopy Open
Visualization of cellular dynamics in the gastrointestinal tract of living mouse model to investigate the pathophysiology has been a long-pursuing goal. Especially, for chronic disease such as Crohn's disease, a longitudinal observation of…
View article: In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy
In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy Open
Microglia are brain resident macrophages rapidly responding to various stimuli to exert appropriate inflammatory responses. Although they have recently been exploited as an attractive candidate for imaging neuroinflammation, it is still di…
View article: Cancer Detection: Microneedle Biosensor for Real‐Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy (Adv. Healthcare Mater. 8/2015)
Cancer Detection: Microneedle Biosensor for Real‐Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy (Adv. Healthcare Mater. 8/2015) Open
A novel microneedle biosensor is developed on page 1153 for real-time electrical detection of nitric oxide (NO) for in situ cancer diagnosis during endomicroscopy. S. K. Hahn and co-workers show that the dual diagnostic system of endomicro…
View article: Dark-field polarization-sensitive optical coherence tomography
Dark-field polarization-sensitive optical coherence tomography Open
Polarization-sensitive optical coherence tomography (PS-OCT) is a functional OCT providing both structural and birefringent information of the sample, and it has been applied to the studies of various organs having polarization properties.…
View article: In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe
In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe Open
We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field r…
View article: A structural remedy toward bright dipolar fluorophores in aqueous media
A structural remedy toward bright dipolar fluorophores in aqueous media Open
Structural factors governing the poor emission of dipolar dyes in aqueous media are identified, leading to new acedan derivatives with brighter fluorescence and enhanced two-photon properties.