Taesic Lee
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The relationship between frailty status and psychosocial indices in older Korean adults Open
Frailty is a heightened vulnerability to physiological stressors caused by cumulative physiological decline over a lifespan. Psychological issues (depression and stress) and social problems (such as loneliness and social isolation) serve a…
Association Between Fasting Insulin Levels and Handgrip Strength: A Cross-Sectional Study Using the Korean National Health and Nutrition Examination Survey Open
Background: Sarcopenia and metabolic dysfunction share common physiological mechanisms, and insulin resistance has been recognized as a major contributor to muscle loss. However, the independent association between circulating fasting insu…
View article: Antidepressant prescriptions by provider in patients with kidney failure and depression
Antidepressant prescriptions by provider in patients with kidney failure and depression Open
Background The prevalence of depression is high among patients with end-stage kidney disease (ESKD). Recent studies have indicated under-recognition and -treatment of depression in this population, and little is known about how the special…
Palmitate impairs autophagic degradation via oxidative stress/perilysosomal Ca2+ overload/mTORC1 activation pathway in pancreatic β cells Open
Saturated fatty acids impose lipotoxic stress on pancreatic β cells, leading to β cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β cell lipotoxicity. Pal…
Waist Circumference as an Independent Marker of Insulin Resistance: Evidence from a Nationwide Korean Population Study Open
Background: Waist circumference (WC) has become an essential diagnostic marker of metabolic syndrome; however, its accuracy in reflecting insulin resistance remains uncertain, particularly among Asian people who develop metabolic complicat…
MON-811 Novel Subclassification Of Low Bone Mass And Its Association With Comorbidities In Korean Older Adults: A Data-driven Cluster Analysis Open
Disclosure: S. Lee: None. T. Lee: None. G. Yoo: None. J. Lim: None. Osteoporosis is commonly observed in older adults and is often accompanied by other chronic conditions. Although the bone mineral density (BMD) T-score is the gold standar…
Association between smoking status and suicidal ideation, planning, and attempts among adults in South Korea: a population-based cross-sectional survey Open
Introduction Suicide is a significant global public health concern influenced by diverse factors. Smoking is associated with an increased risk of suicide-related behaviors, yet age- and sex-specific risks remain unclear. This study examine…
Isolation frequency and antimicrobial susceptibilities of Bacillus species in a tertiary care hospital in Korea in the past four years (2020–2024): a retrospective surveillance study Open
Background: Identifying Bacillus spp. and performing antimicrobial susceptibility testing (AST) is challenging because of their diversity and limited clinical laboratory resources. We investigated the isolation frequency and antimicrobial …
Possible association between metabolic dysfunction-associated steatotic liver disease predictors and hand grip strength Open
Both Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and sarcopenia are associated with numerous chronic diseases, and the link between the two broad-spectrum phenotypes has been extensively researched. We focused on the r…
Comparative Performance Evaluation of Continuous Monitoring Blood Culture Systems Using Simulated Septic Specimen Open
Background/Objectives: Continuous monitoring blood culture systems (CMBCSs) are revolutionary automated instruments that facilitate the rapid identification of pathogens in blood samples from patients with sepsis. However, with only a few …
Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity Open
Saturated fatty acids impose lipotoxic stress on pancreatic β-cells, leading to β-cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β-cell lipotoxicity. Pal…
Identification of Endometriosis Pathophysiologic-Related Genes Based on Meta-Analysis and Bayesian Approach Open
Endometriosis is a complex disease with diverse etiologies, including hormonal, immunological, and environmental factors; however, its exact pathogenesis remains unknown. While surgical approaches are the diagnostic and therapeutic gold st…
View article: Rover engineered to evaluate impacts of microclimatic parameters on pediatric asthma in Dallas schools
Rover engineered to evaluate impacts of microclimatic parameters on pediatric asthma in Dallas schools Open
Pediatric asthma remains a significant health vulnerability for Dallas students due to atmospheric pollutants. While vegetation is known to lower pollution levels, the relationship between specific microclimatic (local atmospheric) and met…
A Machine Learning-Based Model for Preoperative Assessment and Malignancy Prediction in Patients with Atypia of Undetermined Significance Thyroid Nodules Open
Objectives: The aim of this study was to investigate the preoperative clinical and hematologic variables, including the neutrophil-to-lymphocyte ratio (NLR), that can be used to predict malignancy in patients with atypia of undetermined si…
Identification of Endometriosis Pathophysiologic-related Genes Based on Meta-analysis and Bayesian Approach Open
Endometriosis is a complex disease with diverse etiologies, including hormonal, immunological, and environmental factors; however, its exact pathogenesis remains unknown. While surgical approaches are the diagnostic and therapeutic gold st…
Comparative Performance Evaluation of Continuous Monitoring Blood Culture Systems Using Simulated Septic Specimen Open
Background/Objectives: Continuous Monitoring Blood Culture Systems (CMBCS) are revolutionary automated instruments that facilitate the rapid identification of pathogens in blood samples from patients with sepsis. However, with only a few C…
Differential expression of ORAI channels and STIM proteins in renal cell carcinoma subtypes: implications for metastasis and therapeutic targeting Open
Renal cell carcinoma (RCC) presents significant clinical challenges, highlighting the importance of understanding its molecular mechanisms. While store-operated Ca2+ entry (SOCE) is known to play an essential role in tumorigenesis and meta…
Identification of Alcoholic Hepatitis-related Genes using Liver and Blood Transcriptomes Open
Background Alcoholic hepatitis (AH) is a widespread and life-threatening chronic liver condition that poses a risk of short-term mortality if not properly managed. Clinicians often encounter challenges due to insufficient knowledge about t…
Metabolic Outcomes in Non-Alcoholic and Alcoholic Steatotic Liver Disease in among Korean and Adults: A Population-Based Multi-Cohort Study Open
Background and aims This study investigated the prevalence and causal relationships of chronic metabolic diseases (diabetes, hypertension, and dyslipidemia) with steatotic liver disease (SLD), specifically metabolically associated alcoholi…
Machine Learning-Based Model for Preoperative Assessment and Malignancy Prediction in Patients with Atypia of Unde-termined Significance Nodules Open
Purpose: This study aimed to investigate useful preoperative clinical and hematologic variables in predicting malignancy in patients with the atypia of undetermined significance (AUS) nodules, and to suggest a machine learning-based predic…
Development of an equation to predict delta bilirubin levels using machine learning Open
The equation established in this study is practical and can be easily applied in real-time in clinical laboratories.
Association Between Masticatory Difficulty and Chronic Cough in a Korean Population Open
Masticatory difficulty was linked with an elevated chronic cough risk in Korean healthy adults. Further research, including prospective studies and detailed investigations into gastroesophagoeal reflux disease and microbiological studies, …
Effectiveness of the ALT/AST ratio for predicting insulin resistance in a Korean population: A large-scale, cross-sectional cohort study Open
Insulin resistance is a common pathophysiology in patients with type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease. Thus, screening for the risk of insulin resistance is important to prevent disease pro…
Identification of Alcoholic Hepatitis-related and Mesenchymal Stem Cell Therapy Target Genes Open
Background Alcoholic hepatitis (AH) is a widespread and life-threatening chronic liver condition that poses a risk of short-term mortality if not properly managed. Clinicians often encounter challenges due to insufficient knowledge about t…
Validity and Reliability of the Korean Version of Reduced Morningness–Eveningness Questionnaire: Results From a General Population-Based Sample Open
This study finds the Korean version of the rMEQ to be a valid and reliable instrument for assessing chronotype in the general population.