Tae‐Young Jung
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View article: P11.16.A HER2 HETEROGENEITY BETWEEN PRIMARY CANCERS AND BRAIN METASTASES: A RETROSPECTIVE ANALYSIS OF 185 MATCHED PAIRS ACROSS MULTIPLE CANCER TYPES
P11.16.A HER2 HETEROGENEITY BETWEEN PRIMARY CANCERS AND BRAIN METASTASES: A RETROSPECTIVE ANALYSIS OF 185 MATCHED PAIRS ACROSS MULTIPLE CANCER TYPES Open
BACKGROUND HER2 overexpression drives tumor aggressiveness and poor prognosis, serving as a crucial therapeutic target in various malignancies. While HER2’s role in breast cancer metastasis and prognosis is well-documented, its heterogenei…
View article: Central nervous system tumors with BCOR internal tandem duplications: a systematic review of clinical, radiological, and pathological features in 69 cases
Central nervous system tumors with BCOR internal tandem duplications: a systematic review of clinical, radiological, and pathological features in 69 cases Open
Central nervous system tumors with BCL6 corepressor (BCOR) internal tandem duplications (ITDs) constitute a rare, recently characterized pediatric neoplasm with distinct molecular and histopathological features. To date, 69 cases have been…
View article: Lifestyle changes and psychological anxiety during the Coronavirus Disease 2019 pandemic: Using the Korean Community Health Survey
Lifestyle changes and psychological anxiety during the Coronavirus Disease 2019 pandemic: Using the Korean Community Health Survey Open
This study investigated changes in lifestyles and psychological anxiety among Koreans during the Coronavirus Disease 2019 (COVID-19) pandemic using the 2020 data from the nationwide Korean Community Health Survey. The study outcomes were p…
View article: Metastasis‐enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers
Metastasis‐enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers Open
Dear Editor, Temozolomide (TMZ) is a key chemotherapeutic agent for glioblastoma (GBM), but resistance to TMZ and genetic heterogeneity pose significant challenges. Particularly, unmethylated MGMT promoter (unmethyl-MGMT) status has been i…
View article: Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma
Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma Open
Choroid plexus tumors (CPTs) are intraventricular tumors derived from the choroid plexus epithelium and occur frequently in children. The aim of this study was to investigate the genomic and epigenomic characteristics of CPT and identify t…
View article: Meningioma originating from the superior petrosal vein without dural attachment: A case report
Meningioma originating from the superior petrosal vein without dural attachment: A case report Open
BACKGROUND Meningioma in the cerebellopontine angle (CPA) without dural attachment is extremely rare. We report a unique case of meningioma derived from the superior petrosal vein without dural attachment. CASE SUMMARY A 44-year-old right-…
View article: Magnet-Guided Temozolomide and Ferucarbotran Loaded Nanoparticles to Enhance Therapeutic Efficacy in Glioma Model
Magnet-Guided Temozolomide and Ferucarbotran Loaded Nanoparticles to Enhance Therapeutic Efficacy in Glioma Model Open
Background. The aim of the study was to synthesize liposomal nanoparticles loaded with temozolomide and ferucarbotran (LTF) and to evaluate the theranostic effect of LTF in the glioma model. Methods. We synthesized an LTF that could pass t…
View article: Gamma knife radiosurgery as primary management for intracranial meningioma identified as growing on serial imaging
Gamma knife radiosurgery as primary management for intracranial meningioma identified as growing on serial imaging Open
Gamma knife radiosurgery (GKRS) has emerged as a highly effective therapeutic modality for the management of intracranial meningiomas. However, the role of GKRS in treating growing meningiomas detected during active surveillance remains un…
View article: Leksell Frame-Based Stereotactic Biopsy for Infratentorial Tumor : Practical Tips and Considerations
Leksell Frame-Based Stereotactic Biopsy for Infratentorial Tumor : Practical Tips and Considerations Open
The Leksell frame-based transcerebellar approach was proposed with the arc support frame attached upside down to the Z coordinate. This study presented practical tips and considerations for obtaining adequate tissue samples for deep-seated…
View article: Central Nervous System Dissemination of Solitary Sporadic Supratentorial Hemangioblastoma: A Case Report and Literature Review
Central Nervous System Dissemination of Solitary Sporadic Supratentorial Hemangioblastoma: A Case Report and Literature Review Open
We report a patient with whole neuroaxis dissemination of a sporadic supratentorial hemangioblastoma (HB) for more than 15 years. A 68-year-old female patient presented with severe radiating pain in the right leg. Gadolinium-enhanced lumba…
View article: Selective Olefin Production from Naphtha and Methanol Over Zsm-11 Zeolite
Selective Olefin Production from Naphtha and Methanol Over Zsm-11 Zeolite Open
View article: Two-Day Fraction Gamma Knife Radiosurgery for Large Brain Metastasis
Two-Day Fraction Gamma Knife Radiosurgery for Large Brain Metastasis Open
Objective : We investigated how treating large brain metastasis (LBM) using 2-day fraction Gamma Knife radiosurgery (GKRS) affects tumor control and patient survival. A prescription dose of 10.3 Gy was applied for 2 consecutive days, with …
View article: Strategy for dealing with unfamiliar and thick vessels during microvascular decompression: A first case report of hemifacial spasm caused by a persistent primitive trigeminal artery
Strategy for dealing with unfamiliar and thick vessels during microvascular decompression: A first case report of hemifacial spasm caused by a persistent primitive trigeminal artery Open
Rationale: A persistent primitive trigeminal artery (PPTA) is a rare embryonic cerebrovascular anomaly. Hemifacial spasm (HFS) refers to involuntary contractions of facial muscles caused by the compression of blood vessels against the root…
View article: Magnet-guided temozolomide and superparamagnetic iron oxide-loaded nanoparticles to enhance therapeutic efficacy in a glioma model
Magnet-guided temozolomide and superparamagnetic iron oxide-loaded nanoparticles to enhance therapeutic efficacy in a glioma model Open
Background This study aimed to synthesize liposomal nanoparticles loaded with temozolomide and ferucarbotran (LTF) and evaluate their theranostic effects in a glioma model. Results The particle size and surface charge of LTF were measured …
View article: Intracranial Efficacy of Systemic Therapy in Patients with Asymptomatic Brain Metastases from Lung Cancer
Intracranial Efficacy of Systemic Therapy in Patients with Asymptomatic Brain Metastases from Lung Cancer Open
There has been controversy over whether to radiologically follow up or use local treatment for asymptomatic small-sized brain metastases from primary lung cancer. For brain tumors without local treatment, we evaluated potential factors rel…
View article: Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)
Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) Open
View article: Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus irinotecan in a glioblastoma mouse model
Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus irinotecan in a glioblastoma mouse model Open
Various combination treatments have been considered to attain the effective therapy threshold by combining independent antitumor mechanisms against the heterogeneous characteristics of tumor cells in malignant brain tumors. In this study, …
View article: Distinct Specialized Center of Excellence, the Story of Hwasun Neurosurgery at Chonnam National University Hwasun Hospital
Distinct Specialized Center of Excellence, the Story of Hwasun Neurosurgery at Chonnam National University Hwasun Hospital Open
The paper provides a comprehensive overview of the growth and development of Hwasun Neurosurgery at Chonnam National University Hwasun Hospital over the past 18 years. As the first brain tumor center in Korea when it was established in Apr…
View article: Radiologic Follow-up of Ruptured Arachnoid Cysts With or Without Hemorrhage: Five Case Reports and a Review of the Literature
Radiologic Follow-up of Ruptured Arachnoid Cysts With or Without Hemorrhage: Five Case Reports and a Review of the Literature Open
Arachnoid cysts are usually asymptomatic and discovered incidentally. However, cysts may occasionally rupture because of minor head trauma. We describe the radiologic follow-up of 5 patients with ruptured arachnoid cysts featuring spontane…
View article: Different Expression and Clinical Implications of Cancer-Associated Fibroblast (CAF) Markers in Brain Metastases
Different Expression and Clinical Implications of Cancer-Associated Fibroblast (CAF) Markers in Brain Metastases Open
Aims: This study assessed the expression and clinical relevance of cancer-asssociated fibroblast (CAF)-related biomarkers in brain metastasis (BM). Moreover, molecular characterization of patient-derived primary CAFs and normal fibr…
View article: The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model
The long multi-epitope peptide vaccine combined with adjuvants improved the therapeutic effects in a glioblastoma mouse model Open
Emerging data have suggested that single short peptides have limited success as a cancer vaccine; however, extending the short peptides into longer multi-epitope peptides overcame the immune tolerance and induced an immune response. Moreov…
View article: Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study
Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study Open
Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in…
View article: Correction: Visualization of intercellular cargo transfer using upconverting nanoparticles
Correction: Visualization of intercellular cargo transfer using upconverting nanoparticles Open
Correction for ‘Visualization of intercellular cargo transfer using upconverting nanoparticles’ by Yeongchang Goh et al. , Nanoscale , 2022, https://doi.org/10.1039/d2nr01999j.
View article: KITENIN leads to TMZ-resistance in MGMT-unmethylated glioblastoma through enhancement of CD44 and ALDH1A1
KITENIN leads to TMZ-resistance in MGMT-unmethylated glioblastoma through enhancement of CD44 and ALDH1A1 Open
View article: Evolution of the tumor microenvironment toward immune-suppressive seclusion during brain metastasis of breast cancer: implications for targeted therapy
Evolution of the tumor microenvironment toward immune-suppressive seclusion during brain metastasis of breast cancer: implications for targeted therapy Open
View article: Meningioma With Partial and Spontaneous Regression of Peritumoral Edema on Long-Term Follow Up
Meningioma With Partial and Spontaneous Regression of Peritumoral Edema on Long-Term Follow Up Open
Spontaneous regression of meningioma is rarely observed. We report a one person of an incidentally diagnosed meningioma with a spontaneous regression. The 73-year-old female patient without symptoms showed the right sphenoid meningioma wit…
View article: Different expression and clinical implications of cancer-associated fibroblast (CAF) markers in brain metastases
Different expression and clinical implications of cancer-associated fibroblast (CAF) markers in brain metastases Open
View article: Levetiracetam as a sensitizer of concurrent chemoradiotherapy in newly diagnosed glioblastoma: An open‐label phase 2 study
Levetiracetam as a sensitizer of concurrent chemoradiotherapy in newly diagnosed glioblastoma: An open‐label phase 2 study Open
Background An open‐label single‐arm phase 2 study was conducted to evaluate the role of levetiracetam as a sensitizer of concurrent chemoradiotherapy (CCRT) for patients with newly diagnosed glioblastoma. This study aimed to determine the …
View article: The Tumor Control According to Radiation Dose of Gamma Knife Radiosurgery for Small and Medium-Sized Brain Metastases from Non-Small Cell Lung Cancer
The Tumor Control According to Radiation Dose of Gamma Knife Radiosurgery for Small and Medium-Sized Brain Metastases from Non-Small Cell Lung Cancer Open
Objective : The effectiveness of gamma knife radiosurgery (GKR) in the treatment of brain metastases is well established. The aim of this study was to evaluate the efficacy and safety of maximizing the radiation dose in GKR and the factors…
View article: Evolution of the Tumor Microenvironment toward Immune-Suppressive Seclusion during Brain Metastasis of Breast Cancer: Implications for Targeted Therapy
Evolution of the Tumor Microenvironment toward Immune-Suppressive Seclusion during Brain Metastasis of Breast Cancer: Implications for Targeted Therapy Open
Breast cancer (BC) is the second most common solid malignant tumor that metastasizes to the brain. Despite emerging therapies such as immunotherapy, whether the tumor microenvironment (TME) in breast cancer brain metastasis (BCBM) has pote…