Tae Yun Kim
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View article: Gene-modified iPSC-derived MSCs convert immunosuppressive tumor microenvironments (TMEs) into distinct Pro-inflammatory tmes
Gene-modified iPSC-derived MSCs convert immunosuppressive tumor microenvironments (TMEs) into distinct Pro-inflammatory tmes Open
Background: Immunotherapy has transformed cancer care, inducing durable responses in both hematologic and solid tumors. Despite these advances, many patients derive limited benefit, potentially secondary to an immunosuppressive tumor micro…
View article: SaWa-ML: Structure-Aware Pose Correction and Weight Adaptation-Based Robust Multi-Robot Localization
SaWa-ML: Structure-Aware Pose Correction and Weight Adaptation-Based Robust Multi-Robot Localization Open
Multi-robot localization is a crucial task for implementing multi-robot systems. Numerous researchers have proposed optimization-based multi-robot localization methods that use camera, IMU, and UWB sensors. Nevertheless, characteristics of…
View article: Generation of an induced pluripotent stem cell line (PNUYHi003-A) from peripheral blood mononuclear cells of a patient with neuronal intranuclear inclusion disease
Generation of an induced pluripotent stem cell line (PNUYHi003-A) from peripheral blood mononuclear cells of a patient with neuronal intranuclear inclusion disease Open
View article: Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18 Open
The adenovirus-mediated somatic transfer of the embryonic T-box transcription factor 18 ( TBX18 ) gene can convert chamber cardiomyocytes into induced pacemaker cells. However, the translation of therapeutic TBX18-induced cardiac pacing fa…
View article: Surgical Repair of Postinfarction Left Ventricular Pseudoaneurysm
Surgical Repair of Postinfarction Left Ventricular Pseudoaneurysm Open
Left ventricular pseudoaneurysm is a serious and rare disorder that usually develops after acute myocardial infarction. It can lead to potentially lethal mechanical complications, such as acute left ventricular free wall rupture. This repo…
View article: Evaluation of the Analytical Performance of Oncomine Lung cfDNA Assay for Detection of Plasma EGFR Mutations
Evaluation of the Analytical Performance of Oncomine Lung cfDNA Assay for Detection of Plasma EGFR Mutations Open
Background: The clinical utility of circulating tumor DNA (ctDNA) in the early detection of tumor mutations for targeted therapy and the monitoring of tumor recurrence has been reported. However, the analytical validation of ctDNA assays i…
View article: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart
Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart Open
Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with a…
View article: Author response: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart
Author response: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Progressive tissue re…
View article: Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues
Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues Open
Recent advances in human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues provide a unique opportunity for cardiotoxic assessment of pharmaceutical and environmental compounds. Here, we developed a series of automated dat…
View article: Supplemental Materials for "Action Potential Metrics and Automated Data Analysis Pipeline for Cardiotoxicity Testing Using Optically Mapped hiPSC-derived 3D Cardiac Microtissues"
Supplemental Materials for "Action Potential Metrics and Automated Data Analysis Pipeline for Cardiotoxicity Testing Using Optically Mapped hiPSC-derived 3D Cardiac Microtissues" Open
This folder contains samplre raw dataset associated with the publication titled "Action Potential Metrics and Automated Data Analysis Pipeline for Cardiotoxicity Testing Using Optically Mapped hiPSC-derived 3D Cardiac Microtissues". Raw ac…
View article: Targeted Panel Sequencing Identifies an Intronic c.5225-3C>G Variant of the FBN1 Gene Causing Sporadic Marfan Syndrome with Annuloaortic Ectasia
Targeted Panel Sequencing Identifies an Intronic c.5225-3C>G Variant of the FBN1 Gene Causing Sporadic Marfan Syndrome with Annuloaortic Ectasia Open
Marfan syndrome (MFS) is a hereditary connective tissue disease whose clinical severity varies widely. Mutations of the FBN1 gene encoding fibrillin-1 are the most common genetic cause of Marfanoid habitus; however, about 10% of MFS patien…
View article: Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation
Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation Open
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membra…
View article: Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transfer
Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transfer Open
Implantable cardiac pacemaker devices are generally effective for patients with symptomatic bradyarrhythmia. However, device-dependent cardiac pacing is far from ideal and often inadequate, particularly for pediatric patients who need to g…
View article: Methodology for Cross-Talk Elimination in Simultaneous Voltage and Calcium Optical Mapping Measurements With Semasbestic Wavelengths
Methodology for Cross-Talk Elimination in Simultaneous Voltage and Calcium Optical Mapping Measurements With Semasbestic Wavelengths Open
Most cardiac arrhythmias at the whole heart level result from alteration of cell membrane ionic channels and intracellular calcium concentration ([Ca 2+ ] i ) cycling with emerging spatiotemporal behavior through tissue-level coupling. For…
View article: Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia
Ero1α-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia Open
Background: Oxidative stress in cardiac disease promotes proarrhythmic disturbances in Ca 2+ homeostasis, impairing luminal Ca 2+ regulation of the sarcoplasmic reticulum (SR) Ca 2+ release channel, the RyR2 (ryanodine receptor), and incre…
View article: Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart
Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart Open
Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with a…
View article: Magnetic Anisotropy and Magnetic Ordering of Transition-Metal Phosphorus Trisulfides
Magnetic Anisotropy and Magnetic Ordering of Transition-Metal Phosphorus Trisulfides Open
Here, a magnetic model with an unprecedentedly large number of parameters was determined from first-principles calculations for transition-metal phosphorus trisulfides (TMPS$_3$'s), which reproduced the measured magnetic ground states of b…
View article: Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment
Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment Open
View article: Supplemental Materials for "Human Atrial Cardiac Microtissues for Chamber-specific Arrhythmic Risk Assessment"
Supplemental Materials for "Human Atrial Cardiac Microtissues for Chamber-specific Arrhythmic Risk Assessment" Open
This folder contains a sample raw dataset associated with the publication titled "Human Atrial Cardiac Microtissues for Chamber-specific Arrhythmic Risk Assessment". Raw action potential (AP) traces for atrial and ventricular microtissues …
View article: A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues
A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues Open
View article: The Sarcoplasmic Reticulum Oxidoreductase System Modulates Luminal Ca2+ Regulation of the Ryanodine Receptor in Cardiac Disease
The Sarcoplasmic Reticulum Oxidoreductase System Modulates Luminal Ca2+ Regulation of the Ryanodine Receptor in Cardiac Disease Open
View article: A Predictive in Vitro Risk Assessment Platform for Pro-Arrhythmic Toxicity Using Human 3D Cardiac Microtissues
A Predictive in Vitro Risk Assessment Platform for Pro-Arrhythmic Toxicity Using Human 3D Cardiac Microtissues Open
Cardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants can be severe, even life threatening, which necessitates a thorough evaluation of the human response to chemical compounds. Predicting risks for arrh…
View article: Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk
Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk Open
View article: IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias Open
Previous reports indicate that IL18 is a novel candidate gene for diastolic dysfunction in sickle cell disease (SCD)–related cardiomyopathy. We hypothesize that interleukin-18 (IL-18) mediates the development of cardiomyopathy and ventricu…
View article: n‐ZnO/p‐NiO Core/Shell‐Structured Nanorods for Piezoelectric Nanogenerators
n‐ZnO/p‐NiO Core/Shell‐Structured Nanorods for Piezoelectric Nanogenerators Open
A piezoelectric nanogenerator based on a ZnO-NiO core–shell structure with improved output performance by reducing screen effect can be used as a power source for flexible devices by converting mechanical energy into electrical energy. Mor…
View article: Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium
Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium Open
Cardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling. Limitations to these applications still …
View article: Late I <sub>Na</sub> Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2
Late I <sub>Na</sub> Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2 Open
Background: Long QT syndrome has been associated with sudden cardiac death likely caused by early afterdepolarizations (EADs) and polymorphic ventricular tachycardias (PVTs). Suppressing the late sodium current (I NaL ) may counterbalance …
View article: Impact of ISK Voltage and Ca2+/Mg2+-Dependent Rectification on Cardiac Repolarization
Impact of ISK Voltage and Ca2+/Mg2+-Dependent Rectification on Cardiac Repolarization Open
View article: Mutations in KCNE1 Promote Cardiac Alternans in Long QT Syndrome Type 5 Rabbits
Mutations in KCNE1 Promote Cardiac Alternans in Long QT Syndrome Type 5 Rabbits Open
View article: Inhibition of Tyrosine Kinase Pyk2 in Hypertrophic Hearts: Cellular Mechanisms of Anti-Arrhythmic Effects
Inhibition of Tyrosine Kinase Pyk2 in Hypertrophic Hearts: Cellular Mechanisms of Anti-Arrhythmic Effects Open