Taga Lerner
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View article: H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient
H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient Open
H3K27M, a driver mutation with T and B cell neoepitope characteristics, defines an aggressive subtype of diffuse glioma with poor survival. We functionally dissect the immune response of one patient treated with an H3K27M peptide vaccine w…
View article: T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery
T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery Open
Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA–presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applic…
View article: 807 A vaccine targeting the recurrent driver mutation H3K27M induces mutation specific T- and B- cell responses in patients with diffuse midline Gliomas
807 A vaccine targeting the recurrent driver mutation H3K27M induces mutation specific T- and B- cell responses in patients with diffuse midline Gliomas Open
Background Previously, we demonstrated that 5/3 chimeric oncolytic adenoviruses coding for human mucin1 (MUC1) T cell engager boosted intratumoral T cell activation and proliferation, resulting in effective antitumor efficacy in A549 and p…
View article: Boosting class II HLA epitope presentation to T cells with endoplasmic reticulum transmembrane domain fusion proteins
Boosting class II HLA epitope presentation to T cells with endoplasmic reticulum transmembrane domain fusion proteins Open
Antigen processing and presentation are crucial for T-cell receptor engagement and potent adaptive immune responses. While establishing an antigen presentation system to identify TCR-epitope pairs from large libraries of genetically templa…
View article: T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery
T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery Open
Effective, unbiased, high-throughput methods to functionally identify both class II and class I HLA-presented T cell epitopes and their cognate T cell receptors (TCRs) are essential for and prerequisite to diagnostic and therapeutic applic…
View article: Neoepitope-specific vaccination of a patient with diffuse midline glioma targeting H3K27M induces polyclonal B and T cell responses across diverse HLA alleles
Neoepitope-specific vaccination of a patient with diffuse midline glioma targeting H3K27M induces polyclonal B and T cell responses across diverse HLA alleles Open
H3K27M, a driver mutation with T- and B-cell neoepitope characteristics, defines an aggressive subtype of diffuse glioma with poor survival. We functionally dissect the immune response of one patient who was treated with an H3K27M peptide …