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View article: Complement inhibitor use is not a significant predictor of cancer incidence: A real-world study of patients requiring chronic complement blockade.
Complement inhibitor use is not a significant predictor of cancer incidence: A real-world study of patients requiring chronic complement blockade. Open
Complement inhibitors (CI) are the mainstay therapy for classic complement-mediated disorders including paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Emerging recognition of the role of complement…
View article: Using Machine Learning to Predict the Risk of Evolution to Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia
Using Machine Learning to Predict the Risk of Evolution to Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia Open
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder resulting from PIG-A gene mutations, causing loss of expression of CD55 and CD59 and leading to complement-mediated destruction of erythrocytes. With 10% of idiopat…
View article: Paroxysmal nocturnal hemoglobinuria–related thrombosis in the era of novel therapies: a 2043-patient-year analysis
Paroxysmal nocturnal hemoglobinuria–related thrombosis in the era of novel therapies: a 2043-patient-year analysis Open
Thrombophilia is one of the principal features of paroxysmal nocturnal hemoglobinuria (PNH) and constitutes the main cause of disease morbidity/mortality. Anticomplement treatment has revolutionized the natural history of PNH, with control…
View article: Predicting Clonal Evolution to Secondary Myeloid Neoplasms in Aplastic Anemia through Machine Learning
Predicting Clonal Evolution to Secondary Myeloid Neoplasms in Aplastic Anemia through Machine Learning Open
Background: One of the major long-term complications in aplastic anemia (AA) is the clonal evolution to secondary myeloid neoplasms (sMNs) such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) 1. Hematopoietic stem cell t…
View article: SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation
SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation Open
Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic maligna…
View article: Novel Scheme for Defining the Clinical Implications of TP53 Mutations in Myeloid Neoplasia
Novel Scheme for Defining the Clinical Implications of TP53 Mutations in Myeloid Neoplasia Open
Background: TP53 mutations ( TP53 MT ) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, …
View article: Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia Open
Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, whic…
View article: Parafoveal acute middle maculopathy (PAMM) in sickle cell disease after discontinuation of hydroxyurea
Parafoveal acute middle maculopathy (PAMM) in sickle cell disease after discontinuation of hydroxyurea Open
To our knowledge, this is the first report of PAMM after discontinuation of hydroxyurea in preparation for pregnancy. It highlights the importance of a multidisciplinary approach when treating peripartum patients with SCD and the need for …
View article: Molecular patterns identify distinct subclasses of myeloid neoplasia
Molecular patterns identify distinct subclasses of myeloid neoplasia Open
Background Genomic mutations drive the pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). While morphological and clinical features, complemented by cytogenetics, have dominated the classical criteria for dia…
View article: Sars-Cov-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia
Sars-Cov-2 Infection Associated with Aplastic Anemia and Pure Red Cell Aplasia Open
Introduction: Aplastic anemia (AA) is a life-threatening disorder characterized by pancytopenia and a hypocellular bone marrow. Pure red cell aplasia (PRCA) is a similar disorder with primary reduction in the red blood cell population and …
View article: Immature Platelets and Disease Severity in Patients Hospitalized with Acute COVID-19 Who Are Vaccinated Against COVID-19
Immature Platelets and Disease Severity in Patients Hospitalized with Acute COVID-19 Who Are Vaccinated Against COVID-19 Open
Introduction: COVID-19 has killed more than four million people worldwide and resulted in strained health resources globally(Dong Lancet ID 2020). There is a critical need for prognostic biomarkers to predict severity and outcomes in COVID…
View article: The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy
The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy Open
Paroxysmal nocturnal haemoglobinuria (PNH) and idiopathic aplastic anaemia (AA) share common pathogenetic aspects which eventually diverge and thus their clinical course may overlap and cross (Maciejewski et al, 2001a). PNH mutant cells se…
View article: Thrombopoietic status of patients on haemodialysis
Thrombopoietic status of patients on haemodialysis Open
Summary Thrombocytopenia is a potential dialysis‐related treatment complication. Developments in bio‐compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in hae…