Taher Omari
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View article: Acute Effects of the 5‐Hydroxytryptamine Type 4 Receptor Agonist Mosapride on Pharyngeal Swallowing Physiology in Adults
Acute Effects of the 5‐Hydroxytryptamine Type 4 Receptor Agonist Mosapride on Pharyngeal Swallowing Physiology in Adults Open
The 5‐hydroxytryptamine type 4 receptor agonist mosapride is known to modulate esophageal peristalsis and enhance lower esophageal sphincter compliance. However, its impact on oropharyngeal swallowing physiology remains insufficiently char…
View article: Impact of Hiatus Hernia and Reflux on Bolus Transport Through the Esophagus and the Esophagogastric Junction and in Relation to Dysphagia
Impact of Hiatus Hernia and Reflux on Bolus Transport Through the Esophagus and the Esophagogastric Junction and in Relation to Dysphagia Open
Background Dysphagia and reflux are frequently experienced by individuals with hiatus hernia (HH), but the underlying mechanisms are not fully defined in radiological or manometric studies. This study explores the impact of HH on propulsiv…
View article: Effect of Thickened Fluids on Swallowing Function in Oropharyngeal Dysphagia: Impact of Shear Rheology and Disorder Subtype
Effect of Thickened Fluids on Swallowing Function in Oropharyngeal Dysphagia: Impact of Shear Rheology and Disorder Subtype Open
Introduction Fluid thickeners used in the management of oropharyngeal dysphagia exhibit non‐Newtonian shear‐thinning rheology, impacting their viscosity during deglutition. This study investigated how the rheological properties of thickene…
View article: Mucosal impedance as a diagnostic tool for gastroesophageal reflux disease: an update for clinicians
Mucosal impedance as a diagnostic tool for gastroesophageal reflux disease: an update for clinicians Open
Mucosal impedance is a marker of esophageal mucosal integrity and a novel technique for assessing esophageal function and pathology. This article highlights its development and clinical application for gastroesophageal reflux disease (GERD…
View article: Author Correction: Oesophageal atresia
Author Correction: Oesophageal atresia Open
View article: The herbal preparation, STW5‐II, reduces proximal gastric tone and stimulates antral pressures in healthy humans
The herbal preparation, STW5‐II, reduces proximal gastric tone and stimulates antral pressures in healthy humans Open
Background The herbal preparation, STW5‐II, improves upper gastrointestinal symptoms, including abdominal fullness, early satiation, and epigastric pain, in patients with functional dyspepsia, and in preclinical models decreases fundic ton…
View article: Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study
Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study Open
Objectives Abnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinica…
View article: Swallowing biomechanics in tracheostomised critically ill patients compared to age- and gender-matched healthy controls
Swallowing biomechanics in tracheostomised critically ill patients compared to age- and gender-matched healthy controls Open
In a critically ill tracheostomised cohort, UOS dysfunction was the prevalent biomechanical feature, with elevated pharyngeal pressures. Pharyngeal weakness is not contributing to dysphagia in this cohort. Instead, elevated pharyngeal pres…
View article: Clinical application of pharyngeal high-resolution manometry in Ear, Nose and Throat (ENT) practice
Clinical application of pharyngeal high-resolution manometry in Ear, Nose and Throat (ENT) practice Open
Pharyngeal high-resolution manometry with impedance (P-HRM-I) is an emerging, ambulatory swallow assessment for patients with pharyngeal dysphagia. P-HRM-I provides quantifiable biomechanical metrics of the pharynx and upper oesophageal sp…
View article: Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility—A double‐blind randomized cross‐over study in healthy volunteers
Effects of dexmedetomidine on pharyngeal swallowing and esophageal motility—A double‐blind randomized cross‐over study in healthy volunteers Open
Background Sedative agents increase the risk of pulmonary aspiration, where an intact swallowing function is an important defense mechanism. Dexmedetomidine is an α 2 ‐adrenoceptor agonist widely used during procedural sedation due to bene…
View article: Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility
Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility Open
Our work suggests that SLR may have value as a provocative test during HRM, and future outcome studies are warranted to elucidate the clinical relevance of motor abnormalities depicted from SLR.
View article: Effects of the <scp>GABA</scp>(B) agonist baclofen on volitional swallowing in normal subjects
Effects of the <span>GABA</span>(B) agonist baclofen on volitional swallowing in normal subjects Open
The GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known. We investigated the e…
View article: Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function
Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function Open
Esophageal peristalsis consists of initial inhibition (relaxation) followed by excitation (contraction), both of which move sequentially in the aboral direction. Initial inhibition results in receptive relaxation and bolus-induced luminal …
View article: Management of Gastroesophageal Reflux Disease in Esophageal Atresia Patients
Management of Gastroesophageal Reflux Disease in Esophageal Atresia Patients Open
Objectives: After surgical repair, up to 70% of esophageal atresia (EA) patients suffer from gastroesophageal reflux disease (GERD). The ESPGHAN/NASPGHAN guidelines on management of gastrointestinal complications in EA patients were publis…
View article: Characterizing Esophageal Motility in Neonatal Intensive Care Unit Patients Using High Resolution Manometry
Characterizing Esophageal Motility in Neonatal Intensive Care Unit Patients Using High Resolution Manometry Open
Objective To characterize esophageal motility and esophago-gastric junction (EGJ) function during feeding in neonatal intensive care unit (NICU) patients. Patients and Methods High resolution manometry with impedance (HRIM) was used to inv…
View article: Esophageal Bolus Domain Pressure and Peristalsis Associated With Experimental Induction of Esophagogastric Junction Outflow Obstruction
Esophageal Bolus Domain Pressure and Peristalsis Associated With Experimental Induction of Esophagogastric Junction Outflow Obstruction Open
Measuring pressures within the intrabolus domain can quantify changes related to obstruction to outflow and may serve as adjunct measures for confirming a diagnosis EGJ outflow obstruction.
View article: Pharyngo‐Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time
Pharyngo‐Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time Open
Objectives/Hypothesis Modulation of the pharyngeal swallow to bolus volume and viscosity is important for safe swallowing and is commonly studied using high‐resolution pharyngeal manometry (HRPM). Use of unidirectional pressure sensor tech…
View article: Swallowing biomechanics before and following multi-level upper airway surgery for obstructive sleep apnea
Swallowing biomechanics before and following multi-level upper airway surgery for obstructive sleep apnea Open
STUDY OBJECTIVES: The effect of contemporary multi-level upper airway surgery for obstructive sleep apnea on swallowing is unclear. This study assessed the biomechanical swallowing function in participants with obstructive sleep apnea pre-…
View article: Alteraciones de la motilidad esofágica en la manometría de alta resolución: Clasificación de Chicago versión 4.0©
Alteraciones de la motilidad esofágica en la manometría de alta resolución: Clasificación de Chicago versión 4.0© Open
La Clasificación de Chicago v4.0 (CCv4.0) es el esquema actualizado para clasificar las alteraciones de la motilidad esofágica utilizando la métrica de la manometría de alta resolución (HRM). Para desarrollar la CCv4.0, 52 expertos interna…
View article: Cricopharyngeal peroral endoscopic myotomy improves oropharyngeal dysphagia in patients with Parkinson’s disease
Cricopharyngeal peroral endoscopic myotomy improves oropharyngeal dysphagia in patients with Parkinson’s disease Open
Background and study aims Oropharyngeal dysphagia (OPD) is prevalent in patients with Parkinson’s disease (PD). Upper esophageal sphincter (UES) dysfunction is an important pathophysiological factor for OPD in PD. The cricopharyngeus (CP) …
View article: Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea
Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea Open
Schar MS, Omari TI, Woods CM, et al. Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea. J Clin Sleep Med. 2021;17(9):1793-1803.
View article: Diagnosis of Upper Esophageal Sphincter Disorder: A Study in Healthy Volunteers and Patients With Oropharyngeal Dysphagia
Diagnosis of Upper Esophageal Sphincter Disorder: A Study in Healthy Volunteers and Patients With Oropharyngeal Dysphagia Open
View article: Multichannel impedance monitoring for distinguishing nonerosive reflux esophagitis with minor changes on endoscopy in children
Multichannel impedance monitoring for distinguishing nonerosive reflux esophagitis with minor changes on endoscopy in children Open
Objectives: There are reports describing the relationship between baseline impedance level and esophageal mucosal integrity at endoscopy, such as erosive and nonerosive reflux esophagitis. However, many children with symptoms of gastroesop…
View article: Supplementary Tables
Supplementary Tables Open
Table:1Effects of remifentanil and remifentanil with methylnaltrexone on pharyngeal metrics compared to placebo and placebo with methylnaltrexone at different bolus volumes. Table 2:Effects of remifentanil and remifentanil with methylnaltr…
View article: Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup>
Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup> Open
Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high‐resolution manometry (HRM). Fifty‐two diverse international experts separated into seven working subgroups …
View article: Codeine induces increased resistance at the esophagogastric junction but has no effect on motility and bolus flow in the pharynx and upper esophageal sphincter in healthy volunteers: A randomized, double‐blind, placebo‐controlled, cross‐over trial
Codeine induces increased resistance at the esophagogastric junction but has no effect on motility and bolus flow in the pharynx and upper esophageal sphincter in healthy volunteers: A randomized, double‐blind, placebo‐controlled, cross‐over trial Open
Background Chronic opioid use can induce esophageal dysfunction with symptoms resembling achalasia and a manometric pattern of esophagogastric junction—outflow obstruction (EGJ‐OO). However, the effect of opioids in acute setting on pharyn…
View article: Double H-type tracheoesophageal fistula
Double H-type tracheoesophageal fistula Open
Congenital ‘isolated’ tracheoesophageal fistula (TEF) is a rare variant of esophageal atresia, also termed H-type TEF. Even rarer is a double H-type TEF. Here, we report a two-week-old female, with double H-type TEF – one identified pre-op…
View article: Characterization of esophageal motility and esophagogastric junction in preterm infants with bronchopulmonary dysplasia
Characterization of esophageal motility and esophagogastric junction in preterm infants with bronchopulmonary dysplasia Open
Background To characterize esophageal motility and function of the esophagogastric junction (EGJ) in preterm infants with bronchopulmonary dysplasia (BPD). Methods High‐resolution manometry with impedance was used to investigate esophageal…
View article: <i>Erratum</i> to “Omari T. Addendum to A study of dysphagia symptoms and esophageal body function in children undergoing anti‐reflux surgery”
<i>Erratum</i> to “Omari T. Addendum to A study of dysphagia symptoms and esophageal body function in children undergoing anti‐reflux surgery” Open
I refer to my Letter to the Editor entitled “Addendum to A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery”1 suggesting that the pressure-flow index (PFI) composite score, based on high-r…
View article: Effect of esophageal length on high‐resolution manometry metrics: Extension to the neonatal population
Effect of esophageal length on high‐resolution manometry metrics: Extension to the neonatal population Open