Tahereh Setayesh
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View article: A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea
A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea Open
Sickle cell hemoglobin C (HbSC) disease results from compound heterozygosity of hemoglobin S (HbS) and hemoglobin C (HbC), comprising 30% of sickle cell disease (SCD). HbC induces red blood cell (RBC) dehydration/xerocytosis, which promote…
View article: Multi-pathway targeted therapy of MASH-HCC using miR-22
Multi-pathway targeted therapy of MASH-HCC using miR-22 Open
Background The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities are frequen…
View article: Multi-Pathway Targeted Therapy of MASH-HCC Using miR-22
Multi-Pathway Targeted Therapy of MASH-HCC Using miR-22 Open
Background: The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities are freque…
View article: The spatial impact of a Western diet in enriching Galectin-1-regulated Rho, ECM, and SASP signaling in a novel MASH-HCC mouse model
The spatial impact of a Western diet in enriching Galectin-1-regulated Rho, ECM, and SASP signaling in a novel MASH-HCC mouse model Open
Background Hepatocellular carcinoma (HCC) arising from metabolic dysfunction-associated steatohepatitis (MASH) presents a significant clinical challenge, particularly given the prevalence of the Western diet (WD). The influence of diet on …
View article: BCG as an Innovative Option for HCC Treatment: Repurposing and Mechanistic Insights
BCG as an Innovative Option for HCC Treatment: Repurposing and Mechanistic Insights Open
This study investigates Bacillus Calmette‐Guérin (BCG) as a potential treatment for hepatocellular carcinoma (HCC), a condition often associated with unfavorable treatment outcomes. Exploiting BCG's recognized immune‐boosting properties, p…
View article: XKidneyOnco: An Explainable Framework to Classify Renal Oncocytoma and Chromophobe Renal Cell Carcinoma with a Small Sample Size
XKidneyOnco: An Explainable Framework to Classify Renal Oncocytoma and Chromophobe Renal Cell Carcinoma with a Small Sample Size Open
Renal oncocytoma and chromophobe renal cell carcinoma are two kidney cancer types that present a diagnostic challenge to pathologists and other clinicians due to their microscopic similarities. While RO is a benign renal neoplasm, ChRCC is…
View article: Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma
Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma Open
This study examines inhibiting galectin 1 (Gal1) as a treatment option for hepatocellular carcinoma (HCC). Gal1 has immunosuppressive and cancer-promoting roles. Our data showed that Gal1 was highly expressed in human and mouse HCC. The le…
View article: miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism
miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism Open
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and immune effects, including retinoic acids, bile acids, vitamin D3, and short-chain fatty acids. The tumor suppressor effects of miR-22 have been suggested…
View article: The contributions of bacteria metabolites to the development of hepatic encephalopathy
The contributions of bacteria metabolites to the development of hepatic encephalopathy Open
Over 20% of mortality during acute liver failure is associated with the development of hepatic encephalopathy (HE). Thus, HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities ranging from subc…
View article: Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline
Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline Open
It has been shown that the Western diet (WD) induces systemic inflammation and cognitive decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced hepatic inflammation. The current study examines whether sha…
View article: Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma
Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma Open
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans. Abnormal expression of Gals is associated with the development, progression, and metastasis of different types of cancer. Among the 11 Ga…
View article: Alteration of the Iron Level in Iron-overloaded Mice by Magnetospirillum Gryphiswaldense
Alteration of the Iron Level in Iron-overloaded Mice by Magnetospirillum Gryphiswaldense Open
Background Magnetospirillum gryphiswaldense (MSR-1), a type of magnetotactic bacteria are capable of forming magnetosomes, which are nanometer-sized particles and membrane-enclosed organelles containing crystals of magnetite (Fe 3 O 4 ). F…
View article: Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage
Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage Open
Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic ma…
View article: Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice
Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice Open
Obesity is associated with low-grade inflammation, increased ROS production and DNA damage. Supplementation with antioxidants might ameliorate DNA damage and support epigenetic regulation of DNA repair. C57BL/6J male mice were fed a high-f…
View article: EGCG Prevents High Fat Diet‐Induced Changes in Gut Microbiota, Decreases of DNA Strand Breaks, and Changes in Expression and DNA Methylation of <i>Dnmt1</i> and <i>MLH1</i> in C57BL/6J Male Mice
EGCG Prevents High Fat Diet‐Induced Changes in Gut Microbiota, Decreases of DNA Strand Breaks, and Changes in Expression and DNA Methylation of <i>Dnmt1</i> and <i>MLH1</i> in C57BL/6J Male Mice Open
Obesity as a multifactorial disorder involves low‐grade inflammation, increased reactive oxygen species incidence, gut microbiota aberrations, and epigenetic consequences. Thus, prevention and therapies with epigenetic active antioxidants,…
View article: Investigations of the genotoxic properties of two synthetic cathinones (3-MMC, 4-MEC) which are used as psychoactive drugs
Investigations of the genotoxic properties of two synthetic cathinones (3-MMC, 4-MEC) which are used as psychoactive drugs Open
Synthetic cathinones (SCAs) are consumed worldwide as psychostimulants and are increasingly marketed as surrogates of classical illicit drugs via the internet.