Explanipedia

Genetic Variations in Crimean‐Congo Hemorrhagic Fever Virus: Challenges for Molecular Diagnostic Assays—A Case Report Open

Mostafa Salehi‐Vaziri, Tahmineh Jalali, Mahsa Tavakoli, Laya Farhan Asadi, Seyed Marzieh Sajadi , et al. · 2025

Background: Crimean–Congo hemorrhagic fever (CCHF) is a tick‐borne viral disease with a high mortality rate which is endemic in Iran. Laboratory diagnosis of CCHF is routinely conducted using PCR and IgM ELISA tests. However, nucleotide va…

Crimean-Congo haemorrhagic fever among healthcare workers in Iran 2000–2023, a report of National Reference Laboratory Open

Mehdi Fazlalipour, Tahmineh Jalali, Roger Hewson, Mohammad Hassan Pouriayevali, Mostafa Salehi‐Vaziri · 2024

In healthcare settings, physicians and nurses are at risk of nosocomial CCHF virus infection. The routes of transmission mainly include direct exposures via needle-stick, mucosal or direct contact with the skin to infected blood. Continuou…

The first case of Mpox infection in Iran during the 2022 outbreak Open

Ali Maleki, Arash Arashkia, Mohammad Hassan Pouriayevali, Tahmineh Jalali, Mahsa Tavakoli , et al. · 2024

Introduction: The unexpected outbreak of human Mpox infection beginning in some European countries that were non-endemic for Mpox stunned the world during the Coronavirus Disease 2019 (COVID-19) pandemic in May 2022. The re-emerging Mpox o…

Crimean-Congo Hemorrhagic Fever Virus Kinetics in Serum, Saliva, and Urine, Iran, 2018 Open

Maliheh Metanat, Seyed Dawood Mousavi Nasab, Tahmineh Jalali, Fahimeh Bagheri Amiri, Neda Sadat Torab Jahromi , et al. · 2024

Little is known about using noninvasive samples for diagnosing Crimean-Congo hemorrhagic fever (CCHF). We investigated detection of CCHF virus in serum, saliva, and urine samples. Our results indicate that serum is the best sample type for…

Extensive Surveillance of Mosquitoes and Molecular Investigation of Arboviruses in Central Iran; First Record of Molecular Identification of Culex Tarsalis in Qom Province Open

Fatemeh Abedi-Astaneh, Ebrahim Abbasi, Hedaiatollah Raoofi Rad, Mohammad Hassan Pouriayevali, Tahmineh Jalali , et al. · 2024

Evaluation of PastoCovac plus vaccine as a booster dose on vaccinated individuals with inactivated COVID-19 vaccine Open

Behrokh Farahmand, Mona Sadat Larijani, Fatemeh Fotouhi, Alireza Biglari, Rahim Sorouri , et al. · 2023

COVID-19 pandemic has been managed through global vaccination programs. However, the antibody waning in various types of vaccines came to notice. Hereby, PastoCovac Plus as a protein subunit vaccine was investigated in immunized health car…

Aptamer-based diagnosis of various SARS-CoV2 strains isolated from clinical specimens Open

Zahra Sadat Moshref, Tahmineh Jalali, Razieh Rezaei Adriani, Elahe Soltati, Seyed Latif Mousavi Gargari · 2023

The emergence of the SARS-CoV-2 virus, an unknown strain of coronavirus, has resulted in severe acute respiratory syndrome with high mortality rates worldwide. Due to the possibility of asymptomatic carriers, late diagnosis of infected ind…

Efficacy and Safety of a Protein-Based SARS-CoV-2 Vaccine Open

Ehsan Mostafavi, Sana Eybpoosh, Mohammad Karamouzian, Malahat Khalili, Saiedeh Haji‐Maghsoudi , et al. · 2023

Importance The protein-based SARS-CoV-2 vaccines FINLAY-FR-2 (Soberana 02) and FINLAY-FR-1A (Soberana Plus) showed good safety and immunogenicity in phase 1 and 2 trials, but the clinical efficacy of the vaccine remains unknown. Objective …

Implementation of an In-House Platform for Rapid Screening of SARS-CoV-2 Genome Variations Open

Farzane Zare Ashrafi, Marzieh Mohseni, Maryam Beheshtian, Zohreh Fattahi, Fatemeh Ghodratpour , et al. · 2023

Background: Global real-time monitoring of SARS-CoV-2 variants is crucial to controlling the COVID-19 outbreak. The purpose of this study was to set up a Sanger-based platform for massive SARS-CoV-2 variant tracking in laboratories in low-…

Aptamer-based diagnosis of various SARS-CoV2 strains isolated from clinical specimens Open

Zahra Sadat Moshref, Tahmineh Jalali, Razieh Rezaei Adriani, Elahe Soltani, Seyed Latif Mousavi Gargari · 2022

The emergence of SARS-CoV2 virus, an unknown strain of coronavirus caused a severe acute respiratory syndrome with high mortality around the world. Late diagnosis of asymptomatic carriers can lead to uncontrollable transmission of the dise…

Novel Mutations Associated with N-Gene Target Failure in SARS-COV-2 Genome in Iran, Case Series Open

Ali Maleki, Zahra Fereydouni, Mahsa Tavakoli, Akram Ezani, Mirshamsedin Hosseini , et al. · 2022

Precision tracking and monitoring viral genome mutations are critical during a viral pandemic such as COVID-19. As molecular assays for diagnosing numerous infectious agents are being developed, RT-PCR is still deployed as the gold standar…

Sequential HCoV-HKU1 and SARS-CoV-2 Infections, a Case Report Open

Ali Maleki, Mohammad Hassan Pouriayevali, Mahsa Tavakoli, Zahra Ahmadi, Farideh Niknam Oskouei , et al. · 2022

In the SARS-CoV-2 pandemic, the seasonal viral respiratory infections had a minimum prevalence due to public health precautions to reduce the risk of getting Coronavirus Disease 19 (COVID-19). There have been reports of COVID-19 coinfectio…

The ins and outs of SARS-CoV-2 variants of concern (VOCs) Open

Mostafa Salehi‐Vaziri, Mehdi Fazlalipour, Seyed Mahmood Seyed Khorrami, Kayhan Azadmanesh, Mohammad Hassan Pouriayevali , et al. · 2022

SARS-CoV-2 re-infection rate in Iranian COVID-19 cases within one-year follow-up Open

Mostafa Salehi‐Vaziri, Mohammad Hassan Pouriayevali, Fatemeh Fotouhi, Tahmineh Jalali, Mohammad Banifazl , et al. · 2021

Corrigendum to ‘How Iran responded to expanding need for laboratory services for COVID-19?’ Open

Mostafa Salehi‐Vaziri, Arash Arashkia, Ehsan Mostafavi, Tahmineh Jalali, Mohammad Hassan Pouriayevali , et al. · 2021

Disease waves of SARS-CoV-2 in Iran closely mirror global pandemic trends Open

Zohreh Fattahi, Marzieh Mohseni, Maryam Beheshtian, Ali Jafarpour, Khadijeh Jalalvand , et al. · 2021

SARS-CoV-2 genome surveillance projects provide a good measure of transmission and monitor the circulating SARS-CoV-2 variants at regional and global scales. Iran is one of the most affected countries still involved with the virus circulat…

Aptamer based diagnosis of crimean-congo hemorrhagic fever from clinical specimens Open

Tahmineh Jalali, Mostafa Salehi‐Vaziri, Mohammad Hassan Pouriayevali, Seyed Latif Mousavi Gargari · 2021

Evidence of Hantavirus circulation among municipal street sweepers, southwest of Iran Open

Mostafa Salehi‐Vaziri, Jamal Sarvari, Maryam Mansurnejadan, Alireza Shiri, Negar Joharinia , et al. · 2021

How Iran responded to expanding need for laboratory services for COVID-19? Open

Mostafa Salehi‐Vaziri, Arash Arashkia, Ehsan Mostafavi, Tahmineh Jalali, Mohammad Hassan Pouriayevali , et al. · 2021

SARS-CoV-2 presented moderately during two episodes of the infection with lack of antibody responses Open

Mostafa Salehi‐Vaziri, Mir Davood Omrani, Mohammad Hassan Pouriayevali, Fatemeh Fotouhi, Mohammad Banifazl , et al. · 2021

Prolonged viral shedding and antibody persistence in patients with COVID-19 Open

Fatemeh Fotouhi, Mostafa Salehi‐Vaziri, Behrokh Farahmand, Ehsan Mostafavi, Mohammad Hassan Pouriayevali , et al. · 2021

Clinical characteristics of SARS-CoV-2 by re-infection vs. reactivation: a case series from Iran Open

Mostafa Salehi‐Vaziri, Tahmineh Jalali, Behrokh Farahmand, Fatemeh Fotouhi, Mohammad Banifazl , et al. · 2021

Molecular Epidemiology and Phylogeny of Crimean-Congo Haemorrhagic Fever (CCHF) Virus of Ixodid Ticks in Khorasan Razavi Province of Iran Open

Hossein Maghsood, S Nabian, Parviz Shayan, Tahmineh Jalali, Meysam Saboor Darbandi , et al. · 2021

Background: Crimean–Congo hemorrhagic fever (CCHF) is a fatal disease caused by Nairovirus classified within the Bunyaviridae family. The virus is transmitted to humans through the bites of infected ticks or direct contact with viremic ani…

Molecular Assay on Detection of Crimean Congo Hemorrhagic Fever (CCHF) Virus in Ixodid Ticks Collected from Livestock in Slaughterhouse from South of Iran Open

Mostafa Salehi‐Vaziri, Hassan Vatandoost, Alireza Sanei-Dehkordi, Mehdi Fazlalipour, Mohammad Hassan Pouriayevali , et al. · 2020

Background: Ticks are vectors of a wide variety of pathogens that can be transmitted to humans, and tick-borne diseases are a significant public health issue worldwide. The present study was carried out on the hard tick infestation of liv…

Severe acute respiratory syndrome‐coronavirus‐2 spike (S) protein based vaccine candidates: State of the art and future prospects Open

Arash Arashkia, Somayeh Jalilvand, Nasir Mohajel, Atefeh Afchangi, Kayhan Azadmanesh , et al. · 2020

Summary Coronavirus disease 2019 (Covid‐19) is caused by severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) which is responsible for a global pandemic that started in late 2019 in Wuhan, China. To prevent the worldwide spread of …

Imported cases of Chikungunya virus in Iran Open

Mohammad Hassan Pouriayevali, Farshid Rezaei, Tahmineh Jalali, Vahid Baniasadi, Mehdi Fazlalipour , et al. · 2019

Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTagged Nucleoprotein for Potential Application in Diagnosis Open

Tahmineh Jalali, Mostafa Salehi‐Vaziri, Mohammad Hassan Pouriayevali, Seyed Latif Mousavi Gargari · 2019

Our recombinant nucleoprotein can be used in IgM capture ELISA for easy and efficient detection of CCHF in any lab in endemic regions.

Crimean-Congo hemorrhagic fever virus Asia 2 genotype in Qeshm Island, southern Iran: A case report Open

Mostafa Salehi‐Vaziri, Mehdi Fazlalipour, Vahid Baniasadi, MohammadHassan Pouriayevali, Tahmineh Jalali , et al. · 2019

No Detection of Crimean Congo Hemorrhagic Fever (CCHF) Virus in Ticks from Kerman Province of Iran Open

Sahar Khakifirouz, Seyed Javad Mowla, Vahid Baniasadi, Mehdi Fazlalipour, Tahmineh Jalali , et al. · 2018

An Outbreak of Crimean-Congo Hemorrhagic Fever in the South West of Iran Open

Mostafa Salehi‐Vaziri, Shokrollah Salmanzadeh, Vahid Baniasadi, Tahmineh Jalali, Tahereh Mohammadi , et al. · 2016

Introduction: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral zoonotic disease, which is endemic in vast geographic areas including the Middle East. The causative agent, Crimean-Congo hemorrhagic fever virus (CCHFV), is a Nairovir…

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