Taichen Lin
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View article: INNV-59. Neutral Effect of Post-Resection Iron Therapy on Glioblastoma Outcomes: A Retrospective Cohort Study Using Target-Trial Emulation Framework
INNV-59. Neutral Effect of Post-Resection Iron Therapy on Glioblastoma Outcomes: A Retrospective Cohort Study Using Target-Trial Emulation Framework Open
INTRODUCTION Anemia develops in more than half of glioblastoma (GBM) patients during the postoperative and early adjuvant period, driven by surgical blood loss, bone-marrow suppression, and cancer-related inflammation. Iron supplementation…
View article: Furcation-involved class II subclass B molar treated by Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under a microscope: A case report
Furcation-involved class II subclass B molar treated by Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under a microscope: A case report Open
View article: Carbon dioxide laser-assisted bone regenerative therapy without membrane use
Carbon dioxide laser-assisted bone regenerative therapy without membrane use Open
Favorable outcomes have been reported with periodontal regeneration therapies using dental lasers for blood clot formation. Herein, we presented the clinical and radiographic outcomes of carbon dioxide laser-assisted bone regenerative ther…
View article: Obstructive Sleep Apnea and Risk of Respiratory Syncytial Viral Infection: A Retrospective Multi‐Institution Cohort Study
Obstructive Sleep Apnea and Risk of Respiratory Syncytial Viral Infection: A Retrospective Multi‐Institution Cohort Study Open
This retrospective cohort study evaluated the association between obstructive sleep apnea (OSA) and the risk of respiratory syncytial virus (RSV) infection and its complications using data from the TriNetX US Collaborative Database. Patien…
View article: Corylin ameliorates inflammaging and pyroptosis in diabetic periodontitis: A preliminary in vitro study
Corylin ameliorates inflammaging and pyroptosis in diabetic periodontitis: A preliminary in vitro study Open
These findings suggest that Corylin may have therapeutic potential in DP by mitigating AGE-induced inflammaging and pyroptosis. Corylin's ability to promote wound healing and inhibit both cellular senescence and pyroptosis highlights its p…
View article: Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis
Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis Open
Periodontitis is a significant health concern for individuals with diabetes mellitus (DM), characterized by inflammation and periodontium loss. Hyperglycaemia in DM exacerbates susceptibility to periodontitis by inducing inflammaging in th…
View article: Er:YAG laser suppresses pro-inflammatory cytokines expression and inflammasome in human periodontal ligament fibroblasts with Porphyromonas gingivalis-lipopolysaccharide stimulation
Er:YAG laser suppresses pro-inflammatory cytokines expression and inflammasome in human periodontal ligament fibroblasts with Porphyromonas gingivalis-lipopolysaccharide stimulation Open
To our knowledge, this is the first study to look into the laser's implication on the NLRP3 inflammasome in periodontitis models. Our study reveals a crucial role of Er:YAG laser in ameliorating periodontitis in-vitro through the modulatio…
View article: Current status of Er:YAG laser in periodontal surgery
Current status of Er:YAG laser in periodontal surgery Open
Lasers have numerous advantageous tissue interactions such as ablation or vaporization, hemostasis, bacterial killing, as well as biological effects, which induce various beneficial therapeutic effects and biological responses in the tissu…
View article: Resveratrol attenuates advanced glycation end product-induced senescence and inflammation in human gingival fibroblasts
Resveratrol attenuates advanced glycation end product-induced senescence and inflammation in human gingival fibroblasts Open
According to our findings, AGEs increase senescence and the production of proinflammatory cytokines in the gingiva, while the administration of resveratrol impedes inflammaging via suppressing NF-κB signaling pathway.
View article: Er:YAG laser-assisted periodontal regeneration with modified minimally invasive surgical technique (M-MIST) under microscope in an advanced periodontitis case with severe attachment loss beyond the root apex
Er:YAG laser-assisted periodontal regeneration with modified minimally invasive surgical technique (M-MIST) under microscope in an advanced periodontitis case with severe attachment loss beyond the root apex Open
View article: Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts
Quercetin ameliorates advanced glycation end product-induced wound healing impairment and inflammaging in human gingival fibroblasts Open
Accumulation of AGEs can elicit inflammaging in HGFs, as seen by increased pro-inflammatory cytokines, cell senescence expression and oxidative stress. The results proposed that Quercetin is able to ameliorate inflammaging in diabetic peri…
View article: Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under microscope in a severe periodontitis with type 2 diabetes mellitus patient: A case report
Er:YAG laser-assisted comprehensive periodontal pocket therapy (Er-LCPT) under microscope in a severe periodontitis with type 2 diabetes mellitus patient: A case report Open
View article: Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation
Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation Open
: These data showed that high levels of AGEs in the gingiva lead to inflammaging reflected by increased pro-inflammatory cytokines, cell senescence expression and oxidative stress. Vitamin D supplementation can reduce oxidative stress and …
View article: Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminary in vitro study
Bromelain inhibits the inflammation and senescence effect in diabetic periodontitis: A preliminary in vitro study Open
View article: Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis
Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis Open
Diabetes mellitus (DM) is a major worldwide health burden. DM is a metabolic disease characterized by chronic hyperglycemia, and if left untreated, can lead to various complications. Individuals with uncontrolled DM are more susceptible to…
View article: Management of furcation-involved molar using Er:YAG laser-assisted bone regenerative therapy: A case report
Management of furcation-involved molar using Er:YAG laser-assisted bone regenerative therapy: A case report Open
View article: Er:YAG laser-assisted flapless esthetic crown lengthening procedure: A case report
Er:YAG laser-assisted flapless esthetic crown lengthening procedure: A case report Open
View article: Galectin-7 promotes proliferation and wound healing capacities in periodontal ligament fibroblasts by activating ERK signaling
Galectin-7 promotes proliferation and wound healing capacities in periodontal ligament fibroblasts by activating ERK signaling Open
Periodontitis is a progressive inflammation condition and a primary cause of tooth loss in adults. As one of the abundant cell types in the periodontium, periodontal ligament fibroblasts (PDLFs) play an integral role in the maintenance and…
View article: Recommendations for treating stage I-III periodontitis in the Taiwanese population: A consensus report from the Taiwan Academy of Periodontology
Recommendations for treating stage I-III periodontitis in the Taiwanese population: A consensus report from the Taiwan Academy of Periodontology Open
The EFP CPG could be adopted for treating periodontitis and maintaining periodontal health of the Taiwanese population, and anatomical variations should be cautious when the treatment is delivered.
View article: The “Er:YAG laser-assisted periimplantitis total therapy (Er:LPTT)”-a novel procedure to perform periimplantitis treatment with bone regeneration therapy
The “Er:YAG laser-assisted periimplantitis total therapy (Er:LPTT)”-a novel procedure to perform periimplantitis treatment with bone regeneration therapy Open
View article: Clinical evaluation of ridge preservation and augmentation with buccal bone deficiency by Er:YAG laser-assisted bone regenerative therapy
Clinical evaluation of ridge preservation and augmentation with buccal bone deficiency by Er:YAG laser-assisted bone regenerative therapy Open
View article: E3 ligase STUB1 attenuates stemness and tumorigenicity of oral carcinoma cells via transglutaminase 2 regulation
E3 ligase STUB1 attenuates stemness and tumorigenicity of oral carcinoma cells via transglutaminase 2 regulation Open
The abnormal downregulation of STUB1 may lessen its suppressive effect on TGM2, which induced the onset or exacerbated the progression of oral cancer. The therapeutic approach to enhance the expression of STUB1 could be a promising directi…
View article: Er:YAG laser promotes proliferation and wound healing capacity of human periodontal ligament fibroblasts through Galectin-7 induction
Er:YAG laser promotes proliferation and wound healing capacity of human periodontal ligament fibroblasts through Galectin-7 induction Open
Background/purpose: Among various dental lasers, the erbium-doped yttrium-aluminum-garnet (Er:YAG) laser has great potential for periodontal treatment including soft and hard tissue ablation with minimal thermal side effects under suitable…
View article: miR-200a inhibits proliferation rate in drug-induced gingival overgrowth through targeting ZEB2
miR-200a inhibits proliferation rate in drug-induced gingival overgrowth through targeting ZEB2 Open
View article: Inhibition of HIF1A-AS1 impedes the arecoline-induced migration activity of human oral mucosal fibroblasts
Inhibition of HIF1A-AS1 impedes the arecoline-induced migration activity of human oral mucosal fibroblasts Open
Long non-coding RNA hypoxia-inducible factor 1α-antisense RNA 1 (HIF1A-AS1) has been known to participate in various types of malignancies, but its role in the development of precancerous oral submucous fibrosis (OSF) has not been investig…
View article: The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study
The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study Open
Pneumonia is a common respiratory infectious disease that involves the inflammation of the pulmonary parenchyma. Periodontal disease is widespread and correlated with pneumonia. However, the relationship between periodontal treatment and c…
View article: The regulation of Oct4 in human gingival fibroblasts stimulated by cyclosporine A: Preliminary observations
The regulation of Oct4 in human gingival fibroblasts stimulated by cyclosporine A: Preliminary observations Open
View article: Clinical evaluation of multiple peri-implant bony defect management by Er:YAG laser-assisted bone regenerative therapy
Clinical evaluation of multiple peri-implant bony defect management by Er:YAG laser-assisted bone regenerative therapy Open
View article: miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis
miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis Open
MiR-1246 is not only critical to the maintenance of oral stemness but also important to the activation of myofibroblasts. Our results showed that miR-1246 is positively associated with the type I collagen, which may be a downstream effecto…
View article: Down-regulation of miR-200b-targeting Slug axis by cyclosporine A in human gingival fibroblasts
Down-regulation of miR-200b-targeting Slug axis by cyclosporine A in human gingival fibroblasts Open
Repression of miR-200b after CsA administration led to an increase in Slug expression. Our results suggested that miR-200b was an upstream effector of the CsA-induced EMT and may act as a therapeutic target for CsA-induced gingival overgro…