Taicheng Zhou
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View article: Multifunctional Small Intestinal Submucosa Mesh for Scarless Abdominal Wall Defect Repair
Multifunctional Small Intestinal Submucosa Mesh for Scarless Abdominal Wall Defect Repair Open
Decellularized small intestinal submucosa (SIS) mesh used for the treatment of abdominal wall defects often suffers from a high risk of recurrence due to early degradation and poor neovascularization. Currently, improving the functionality…
View article: Corrigendum/Erratum to “T cell exhaustion associated genes IRF1 and PDGFRB modulate immune infiltration and affect prognosis in colon adenocarcinoma” [Heliyon Volume 11, Issue 14, September 2025, Article e43767]
Corrigendum/Erratum to “T cell exhaustion associated genes IRF1 and PDGFRB modulate immune infiltration and affect prognosis in colon adenocarcinoma” [Heliyon Volume 11, Issue 14, September 2025, Article e43767] Open
View article: Adaptive Evolution and Distinct Mutation Signatures of Full‐Length HBV Quasispecies in HBeAg‐Negative Chronic Hepatitis B
Adaptive Evolution and Distinct Mutation Signatures of Full‐Length HBV Quasispecies in HBeAg‐Negative Chronic Hepatitis B Open
The evolutionary profile of hepatitis B virus (HBV) quasispecies may influence the clinical course of chronic hepatitis B (CHB), but few studies have characterized quasispecies according to hepatitis B e antigen (HBeAg) status. In this stu…
View article: A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues
A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues Open
The scID-PCR platform offers a novel and powerful approach to quantify intrahepatic HBV-positive cells with single-cell resolution. This method complements traditional serological markers offering a more nuanced view of CHB infection dynam…
View article: Mapping immune imprinting zones enables predictive vaccination optimization
Mapping immune imprinting zones enables predictive vaccination optimization Open
Immune imprinting, where prior exposures shape antibody responses to variant antigens, remains a central obstacle to optimizing vaccination against evolving viruses. Here, we present DynaVac, a mechanistic framework that models antigen-spe…
View article: Age as a non-contraindication for surgical intervention in patients with abdominal wall incisional hernia: an exploration and analysis
Age as a non-contraindication for surgical intervention in patients with abdominal wall incisional hernia: an exploration and analysis Open
View article: Genetic architecture of adaptive immune responses and adverse reactions to inactivated COVID-19 vaccine
Genetic architecture of adaptive immune responses and adverse reactions to inactivated COVID-19 vaccine Open
Host genetic determinants influence vaccine efficacy. The majority of participants in current COVID-19 vaccine genetic studies are of European ancestry, and the basis for individual differences in cell phenotypes is largely unclear. Here, …
View article: Corrigendum: Targeting mitochondrial damage: shining a new light on immunotherapy
Corrigendum: Targeting mitochondrial damage: shining a new light on immunotherapy Open
[This corrects the article DOI: 10.3389/fimmu.2024.1432633.].
View article: Whole-exome sequencing uncovers the genetic basis of hereditary concomitant exotropia in ten Chinese pedigrees
Whole-exome sequencing uncovers the genetic basis of hereditary concomitant exotropia in ten Chinese pedigrees Open
View article: Age as a Non-Contraindication for Surgical Intervention in Patients with Abdominal Wall Incisional Hernia: An Exploration and Analysis
Age as a Non-Contraindication for Surgical Intervention in Patients with Abdominal Wall Incisional Hernia: An Exploration and Analysis Open
Background Surgery is the only potential curative option in patients presenting with abdominal wall incisional hernia (IH). The approach clearly enhances patients' quality of life and reduces complications, however, the management of patie…
View article: Targeting mitochondrial damage: shining a new light on immunotherapy
Targeting mitochondrial damage: shining a new light on immunotherapy Open
Mitochondrial damage has a particular impact on the immune system and tumor microenvironment, which can trigger cell stress, an inflammatory response, and disrupt immune cell function, thus all of which can accelerate the progression of th…
View article: Geographic Heterogeneity in Behavioral and Social Drivers of COVID-19 Vaccination
Geographic Heterogeneity in Behavioral and Social Drivers of COVID-19 Vaccination Open
View article: Laparoscopic treatment of abdominal wall endometriosis: A case series
Laparoscopic treatment of abdominal wall endometriosis: A case series Open
View article: The novel circRNA hsa_circ_0000038 inhibits the progression of hepatocellular carcinoma by sponging miR-92a-2-5p to regulate the p53/p21 proteins
The novel circRNA hsa_circ_0000038 inhibits the progression of hepatocellular carcinoma by sponging miR-92a-2-5p to regulate the p53/p21 proteins Open
Background The abnormal regulation of circular RNA (circRNA) levels is commonly identified in human diseases, particularly malignant tumors. Recently, the diagnostic value of circRNAs has received increased attention. The detailed mechanis…
View article: Safety, immunogenicity, and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containing bivalent mRNA vaccine
Safety, immunogenicity, and preliminary efficacy of a randomized clinical trial of omicron XBB.1.5-containing bivalent mRNA vaccine Open
Periodically updating COVID-19 vaccines that offer broad-spectrum protection is needed given the strong immune evasion by the circulating omicron sublineages. The effectiveness of prototype and BA.4/5-containing bivalent mRNA vaccines is r…
View article: Single-cell multiomics analysis reveals SARS-CoV-2 inactivated vaccine-induced trained immunity modulated by epigenetic remodeling
Single-cell multiomics analysis reveals SARS-CoV-2 inactivated vaccine-induced trained immunity modulated by epigenetic remodeling Open
Recent studies have revealed gene-expression signatures in response to vaccination; however, the epigenetic regulatory mechanisms that are underlying vaccine-induced immune responses remains to be elucidated. Here, we analyzed a multiomics…
View article: Laparoscopic management of diaphragmatic eventration: a three-step procedure of diaphragm reconstruction
Laparoscopic management of diaphragmatic eventration: a three-step procedure of diaphragm reconstruction Open
View article: Machine Learning Risk Prediction Model for 6-Month Postoperative Prognosis after Anti-Reflux Surgery for Gastroesophageal Reflux Disease
Machine Learning Risk Prediction Model for 6-Month Postoperative Prognosis after Anti-Reflux Surgery for Gastroesophageal Reflux Disease Open
Background: Anti-reflux surgery is an effective treatment for GERD, but personalized prognosis tools are lacking. Methods: This prospective study included patients undergoing laparoscopic anti-reflux surgery at a single center. The outcome…
View article: Factors influencing postoperative symptom improvement in hiatal hernia patients and construction of a clinical prediction model
Factors influencing postoperative symptom improvement in hiatal hernia patients and construction of a clinical prediction model Open
Purpose: Our purpose was to analyze the factors influencing the improvement of symptoms postoperatively in patients with a hiatal hernia (HH), and build a clinical prediction model. Methods: The records of 121 patients with a HH who receiv…
View article: circMSH3 is a potential biomarker for the diagnosis of colorectal cancer and affects the distant metastasis of colorectal cancer
circMSH3 is a potential biomarker for the diagnosis of colorectal cancer and affects the distant metastasis of colorectal cancer Open
Objectives To identify the most significantly differentially expressed circular RNAs (circRNAs) in colorectal cancer (CRC) tissues in terms of their expression levels and circularity, and to analyze the relationship between their expressio…
View article: KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress Open
In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of these cell fate decisions remain largely unknown, particularly in normal cells.…
View article: Identification of pyroptosis-related lncRNAs as potential prognostic biomarkers in patients with adenocarcinoma of the esophagogastric junction
Identification of pyroptosis-related lncRNAs as potential prognostic biomarkers in patients with adenocarcinoma of the esophagogastric junction Open
Background Adenocarcinoma of esophagogastric junction (AEG) is a high-mortality gastrointestinal cancer lacking effective prognostic markers. Pyroptosis, a form of programmed cell death, is vital in inflammation and immune response. Howeve…
View article: Chinese consensus on multidisciplinary diagnosis and treatment of gastroesophageal reflux disease 2022
Chinese consensus on multidisciplinary diagnosis and treatment of gastroesophageal reflux disease 2022 Open
View article: Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose
Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose Open
View article: Retrospective study of the immunogenicity and safety of the CoronaVac SARS-CoV-2 vaccine in people with underlying medical conditions
Retrospective study of the immunogenicity and safety of the CoronaVac SARS-CoV-2 vaccine in people with underlying medical conditions Open
Background People living with chronic disease, particularly seniors (≥60 years old), made up of most severe symptom and death cases among SARS-CoV-2 infected patients. However, they are lagging behind in the national COVID-19 vaccination c…
View article: Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China
Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China Open
Based on the simple and intuitive decision tree model constructed in this study, DR classification outcomes were easily obtained by evaluating diabetes duration, CKD stage, supine or standing SBP, and BMI.
View article: Concurrence of novel mutations causing Gilbert’s and Dubin–Johnson syndrome with poor clinical outcomes in a Han Chinese family
Concurrence of novel mutations causing Gilbert’s and Dubin–Johnson syndrome with poor clinical outcomes in a Han Chinese family Open
View article: Cuproptosis-related long non-coding RNAs model that effectively predicts prognosis in hepatocellular carcinoma
Cuproptosis-related long non-coding RNAs model that effectively predicts prognosis in hepatocellular carcinoma Open
The lncRNA signature, CupRLSig, constructed in this study is valuable in prognostic estimation of HCC. Importantly, CupRLSig also predicts the level of immune infiltration and potential efficacy of tumor immunotherapy.
View article: Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial
Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial Open
Yunnan Provincial Science and Technology Department China (202102AA100051 and 202003AC100010), the Double First-class University funding to Yunnan University, National Natural Science Foundation of China (81960116, 82060368 and 82170711), …
View article: A novel nonsense variant (c.1499C>G) in CRB1 caused Leber congenital amaurosis-8 in a Chinese family and a literature review
A novel nonsense variant (c.1499C>G) in CRB1 caused Leber congenital amaurosis-8 in a Chinese family and a literature review Open
Background Leber’s congenital amaurosis (LCA) is a severe hereditary retinopathy disease that is characterized by early and severe reduction of vision, nystagmus, and sluggish or absent pupillary responses. To date, the pathogenesis of LCA…