Taihao Quan
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View article: IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1
IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1 Open
Collectively, our present study suggests that IBSP promotes the malignant process in hypertrophic scar fibroblasts.
View article: Cross-Sectional Study: Associations of A20 and Cezanne with Leukocyte Accumulation in B-Cell Acute Lymphoblastic Leukemia
Cross-Sectional Study: Associations of A20 and Cezanne with Leukocyte Accumulation in B-Cell Acute Lymphoblastic Leukemia Open
Background and Objectives: Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the aberrant proliferation of immature lymphoid cells. Lymphoblasts derived from the B-cell lymphoid lineage are identified as B-ALL…
View article: Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects
Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects Open
Tissue fibrosis, characterized by excessive collagen accumulation, leads to impaired organ function and is a hallmark of various chronic diseases. Fibroblasts play a central role in collagen production and deposition. This study examines t…
View article: CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts
CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts Open
CCN2 is widely regarded as a profibrotic factor involved in fibrotic disorders by regulating extracellular matrix (ECM). We report here that CCN2 functions as a critical cell cycle regulator in primary human dermal fibroblasts (HDFs). siRN…
View article: Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo
Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo Open
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin. Recently, we reported notabl…
View article: Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis
Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis Open
Tissue fibrosis represents a complex pathological condition characterized by the excessive accumulation of collagenous extracellular matrix (ECM) components, resulting in impaired organ function. Fibroblasts are central to the fibrotic pro…
View article: Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging
Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging Open
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the Hippo signaling pathway, which plays a central role in tissue homeostasis, organ development, and regeneration. W…
View article: Age-related changes in dermal collagen physical properties in human skin
Age-related changes in dermal collagen physical properties in human skin Open
Collagen is the major structural protein in the skin. Fragmentation and disorganization of the collagen fibrils are the hallmarks of the aged human skin dermis. These age-related alterations of collagen fibrils impair skin structural integ…
View article: Human Skin Aging and the Anti-Aging Properties of Retinol
Human Skin Aging and the Anti-Aging Properties of Retinol Open
The skin is the most-extensive and -abundant tissue in the human body. Like many organs, as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This can be primarily attributed to the diminishing population of …
View article: CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix Open
Skin primarily comprises a collagen-rich extracellular matrix (ECM) that provides structural and functional support to the skin. Aging causes progressive loss and fragmentation of dermal collagen fibrils, leading to thin and weakened skin …
View article: 305 Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin
305 Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin Open
View article: Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes Open
This article summarizes important molecular mechanisms that drive aging in human skin from the perspective of dermal fibroblasts. The dermis comprises the bulk of the skin and is largely composed of a collagen-rich extracellular matrix (EC…
View article: 363 Elevated expression of CCN1 in dermal fibroblasts causes accelerated dermal aging and promotes keratinocyte carcinogenesis
363 Elevated expression of CCN1 in dermal fibroblasts causes accelerated dermal aging and promotes keratinocyte carcinogenesis Open
View article: Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin
Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin Open
View article: Age-Related Downregulation of CCN2 Is Regulated by Cell Size in a YAP/TAZ-Dependent Manner in Human Dermal Fibroblasts: Impact on Dermal Aging
Age-Related Downregulation of CCN2 Is Regulated by Cell Size in a YAP/TAZ-Dependent Manner in Human Dermal Fibroblasts: Impact on Dermal Aging Open
CCN2, a member of the CCN family of matricellular proteins, is a key mediator and biomarker of tissue fibrosis. We previously reported that CCN2 is significantly reduced in aged human dermis, which contributes to dermal aging through the d…
View article: Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging
Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging Open
Collagen 17A1 (COL17A1) is a transmembrane structural component of the hemidesmosome that mediate adhesion of keratinocytes to the underlying membrane. Recent work in mouse showed that COL17A1 deficiency leads to premature skin aging. Alth…
View article: Age-related elevation of HGF is driven by the reduction of fibroblast size in a YAP/TAZ/CCN2 axis-dependent manner
Age-related elevation of HGF is driven by the reduction of fibroblast size in a YAP/TAZ/CCN2 axis-dependent manner Open
View article: Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging
Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging Open
View article: Alterations in extracellular matrix composition during aging and photoaging of the skin
Alterations in extracellular matrix composition during aging and photoaging of the skin Open
Human skin is composed of the cell-rich epidermis, the extracellular matrix (ECM) rich dermis, and the hypodermis. Within the dermis, a dense network of ECM proteins provides structural support to the skin and regulates a wide variety of s…
View article: Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties
Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties Open
Fragmentation of collagen fibrils and aberrant elastic material (solar elastosis) in the dermal extracellular matrix ( ECM ) is among the most prominent features of photodamaged human skin. These alterations impair the structural integrity…
View article: Actin cytoskeleton assembly regulates collagen production via TGF‐β type II receptor in human skin fibroblasts
Actin cytoskeleton assembly regulates collagen production via TGF‐β type II receptor in human skin fibroblasts Open
The dermal compartment of skin is primarily composed of collagen‐rich extracellular matrix (ECM), which is produced by dermal fibroblasts. In Young skin, fibroblasts attach to the ECM through integrins. During ageing, fragmentation of the …
View article: YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts
YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts Open
YAP/TAZ functions in concert with transcription factor AP-1 and Smad7 to regulate TGF-β signaling, in human dermal fibroblasts. Reduction of YAP/TAZ levels leads to activation of AP-1 activity, which induces Smad7. Smad7 suppresses the TGF…
View article: Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging
Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging Open
The dermal extracellular matrix (ECM) comprises the bulk of skin and confers strength and resiliency. In young skin, fibroblasts produce and adhere to the dermal ECM, which is composed primarily of type I collagen fibrils. Adherence allows…
View article: Ezrin regulates skin fibroblast size/mechanical properties and YAP-dependent proliferation
Ezrin regulates skin fibroblast size/mechanical properties and YAP-dependent proliferation Open
Ezrin acts as a dynamic linkage between plasma membrane and cytoskeleton, and thus involved in many fundamental cellular functions. Yet, its potential role in human skin is virtually unknown. Here we investigate the role of Ezrin in primar…
View article: Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts Open
The potential involvement of connective tissue growth factor (CCN2/CTGF) in extracellular matrix (ECM) production is recognized. However, the role CCN2 in fibronectin (FN) gene expression has remained incompletely understood and even contr…
View article: Age‐related reduction of dermal fibroblast size upregulates multiple matrix metalloproteinases as observed in aged human skin <i>in vivo</i>
Age‐related reduction of dermal fibroblast size upregulates multiple matrix metalloproteinases as observed in aged human skin <i>in vivo</i> Open
Combined actions of the wide variety of MMPs that are constitutively elevated in aged dermis may be involved in the progressive degradation of dermal collagen fibrils. Age-related elevations of multiple MMPs are likely to be a result of th…
View article: PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer
PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer Open
Molecule-targeted therapy has achieved great progress in cancer therapy. Effective drug combinations are one way to enhance the therapeutic efficacy and combat resistance. Here, we determined the effect of the PI3K/mTOR dual inhibitor BEZ2…
View article: Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC
Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC Open
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. NSCLC development and progression have recently been correlated with the heightened activation of histone deacetylases (HDACs) and PI3K/Akt signalin…
View article: Oxidative Stress and Human Skin Connective Tissue Aging
Oxidative Stress and Human Skin Connective Tissue Aging Open
Everyone desires healthy and beautiful-looking skin. However, as we age, our skin becomes old due to physiological changes. Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is exposed to R…
View article: Molecular basis of retinol anti‐ageing properties in naturally aged human skin <i>in vivo</i>
Molecular basis of retinol anti‐ageing properties in naturally aged human skin <i>in vivo</i> Open
Objective Retinoic acid has been shown to improve the aged‐appearing skin. However, less is known about the anti‐ageing effects of retinol ( ROL , vitamin A), a precursor of retinoic acid, in aged human skin in vivo . This study aimed to i…