Taihao Yang
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View article: Siderophore-mediated iron acquisition by <i>Klebsiella pneumoniae</i>
Siderophore-mediated iron acquisition by <i>Klebsiella pneumoniae</i> Open
Microbes synthesize and secrete siderophores, that bind and solubilize precipitated or otherwise unavailable iron in their microenvironments. Gram (−) bacterial TonB-dependent outer membrane receptors capture the resulting ferric sideropho…
View article: Specificity and mechanism of TonB-dependent ferric catecholate uptake by Fiu
Specificity and mechanism of TonB-dependent ferric catecholate uptake by Fiu Open
We studied the Escherichia coli outer membrane protein Fiu, a presumed transporter of monomeric ferric catecholates, by introducing Cys residues in its surface loops and modifying them with fluorescein maleimide (FM). Fiu-FM bound iron com…
View article: Fluorescent sensors of siderophores produced by bacterial pathogens
Fluorescent sensors of siderophores produced by bacterial pathogens Open
Siderophores are iron-chelating molecules that solubilize Fe3+ for microbial utilization and facilitate colonization or infection of eukaryotes by liberating host iron for bacterial uptake. By fluorescently labeling membrane receptors and …
View article: Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics
Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics Open
Iron is an indispensable metabolic cofactor in both pro- and eukaryotes, which engenders a natural competition for the metal between bacterial pathogens and their human or animal hosts. Bacteria secrete siderophores that extract Fe3+ from …
View article: Universal fluorescent sensors of high-affinity iron transport, applied to ESKAPE pathogens
Universal fluorescent sensors of high-affinity iron transport, applied to ESKAPE pathogens Open
Sensitive assays of biochemical specificity, affinity, and capacity are valuable both for basic research and drug discovery. We created fluorescent sensors that monitor high-affinity binding reactions and used them to study iron acquisitio…