Taiki Okumura
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View article: Effect of Dotinurad on Uric Acid and Hepatorenal Parameters in Steatotic Liver Disease: A Pilot Study in Japanese Patients
Effect of Dotinurad on Uric Acid and Hepatorenal Parameters in Steatotic Liver Disease: A Pilot Study in Japanese Patients Open
Background: Dotinurad (DOT) has demonstrated beneficial metabolic effects in preclinical models as a selective uric acid reabsorption inhibitor. However, its clinical impact on steatotic liver disease (SLD) with hyperuricemia (HU-SLD) rema…
View article: Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study
Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study Open
Background & Aims Primary biliary cholangitis (PBC) is a chronic, slowly progressive, and autoimmune liver disease. This study aimed to establish the clinicopathological features that accurately predict long‐term prognosis in patients with…
View article: <scp>AI</scp>‐Based Platelet‐Independent Noninvasive Test for Liver Fibrosis in <scp>MASLD</scp> Patients
<span>AI</span>‐Based Platelet‐Independent Noninvasive Test for Liver Fibrosis in <span>MASLD</span> Patients Open
Background and Aim Noninvasive tests (NITs), such as platelet‐based indices and ultrasound/MRI elastography, are widely used to assess liver fibrosis in metabolic dysfunction‐associated steatotic liver disease (MASLD). However, platelet co…
View article: Growing evidence on the highly sensitive iTACT assay of hepatitis B core-related antigen for predicting hepatitis B virus reactivation
Growing evidence on the highly sensitive iTACT assay of hepatitis B core-related antigen for predicting hepatitis B virus reactivation Open
View article: Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy
Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy Open
Thrombospondin 2 (TSP2) plays a vital role in collagen/fibrin formation, bone growth, vascular density regulation, hemostasis, and cell adhesion. Close associations of serum TSP2 with histological severity in non-alcoholic fatty liver dise…
View article: Serum Autotaxin Levels Predict Liver-Related Events in Patients With Primary Biliary Cholangitis: A Long-Term Multicenter Observational Study
Serum Autotaxin Levels Predict Liver-Related Events in Patients With Primary Biliary Cholangitis: A Long-Term Multicenter Observational Study Open
INTRODUCTION: A straightforward, reliable, and noninvasive method for predicting the development of liver-related events (LRE) in primary biliary cholangitis (PBC) has not been attained thus far. This study investigated whether serum autot…
View article: Thrombospondin 2 as a Predictive Biomarker for <scp>HCC</scp> in Hepatitis C Patients: A Longitudinal Study Following <scp>DAA</scp> Therapy
Thrombospondin 2 as a Predictive Biomarker for <span>HCC</span> in Hepatitis C Patients: A Longitudinal Study Following <span>DAA</span> Therapy Open
This multicentre study investigated the dynamics of thrombospondin 2 (TSP2) levels during direct‐acting antiviral (DAA) therapy in hepatitis C virus (HCV) infected patients and evaluated TSP2's potential as a predictive marker for hepatoce…
View article: Hepatitis B surface antigen glycan isomer as a new potential biomarker in patients with hepatitis B virus infection
Hepatitis B surface antigen glycan isomer as a new potential biomarker in patients with hepatitis B virus infection Open
It is estimated that over 254 million people worldwide are infected with HBV, causing roughly 1.1 million deaths annually1 as HBV infection progresses to liver cirrhosis and HCC.2, 3 Nucleoside/nucleotide analogs and pegylated interferon a…
View article: Long-Term pemafibrate treatment exhibits limited impact on body fat mass in patients with hypertriglyceridemia accompanying NAFLD
Long-Term pemafibrate treatment exhibits limited impact on body fat mass in patients with hypertriglyceridemia accompanying NAFLD Open
Aim Short-term use of pemafibrate (PEM), a selective modulator of peroxisome proliferator-activated receptor alpha, has been reported to improve abnormal liver function in patients with nonalcoholic fatty liver disease with hypertriglyceri…
View article: Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease
Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease Open
View article: Detection Rates of Hepatitis B Surface and Core-related Antigens Using Novel Highly Sensitive Assays in Chronic Hepatitis B Patients With Hepatitis B Surface Antigen Seroclearance
Detection Rates of Hepatitis B Surface and Core-related Antigens Using Novel Highly Sensitive Assays in Chronic Hepatitis B Patients With Hepatitis B Surface Antigen Seroclearance Open
View article: Thrombospondin 2 in Hepatitis B: A Prognostic Insight into Hepatocellular Carcinoma Risk During Nucleos(t)ide Analog Therapy
Thrombospondin 2 in Hepatitis B: A Prognostic Insight into Hepatocellular Carcinoma Risk During Nucleos(t)ide Analog Therapy Open
Aims Thrombospondin 2 (TSP2) plays a vital role in collagen/fibrin formation, bone growth, vascular density regulation, hemostasis, and cell adhesion. We earlier revealed close associations of serum TSP2 with histological severity in non-a…
View article: Clinical utility of additional HCV core antigen measurement in residual serum of HCV antibody-positive patients towards HCV elimination
Clinical utility of additional HCV core antigen measurement in residual serum of HCV antibody-positive patients towards HCV elimination Open
HCV抗体検査受検者を対象とし,HCV抗体陽性者の残血清を用いてHCVコア抗原を測定し,受診勧奨を行うことの有用性を前向き非介入観察研究で検討した.HCV抗体陽性率は4.4%(390/8,805例)であった.また,HCVコア抗原陽性率は8.2%(31/378例)であり,HCV抗体価10以上群(n=249)では10未満群(n=129)より高かった(11.6% vs. 1.6%,P=0.002).31例中29例で受診勧奨を行った.1例はHCV-RNAの陰性が確認された.残りの2…
View article: Prognostic Significance of C-Reactive Protein in Lenvatinib-Treated Unresectable Hepatocellular Carcinoma: A Multi-Institutional Study
Prognostic Significance of C-Reactive Protein in Lenvatinib-Treated Unresectable Hepatocellular Carcinoma: A Multi-Institutional Study Open
Background: Serum C-reactive protein (CRP) is an established biomarker for acute inflammation and has been identified as a prognostic indicator for hepatocellular carcinoma (HCC). However, the significance of the serum CRP level, specifica…
View article: Pyogenic liver abscess associated with Klebsiella oxytoca: Mimicking invasive liver abscess syndrome
Pyogenic liver abscess associated with Klebsiella oxytoca: Mimicking invasive liver abscess syndrome Open
View article: Symptom‐based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease
Symptom‐based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease Open
Background and Aim As the exact prevalence of portopulmonary hypertension (PoPH) and the etiology of chronic liver disease (CLD) remain unknown, the present study aimed to clarify these points in Japanese patients with CLD using symptom‐ba…
View article: Serum Autotaxin is a Prognostic Indicator of Liver-related Events in Patients with Non-alcoholic Fatty Liver Disease
Serum Autotaxin is a Prognostic Indicator of Liver-related Events in Patients with Non-alcoholic Fatty Liver Disease Open
Background Circulating autotaxin (ATX) levels have been reported to correlate with liver inflammation activity and liver fibrosis severity in patients with non-alcoholic fatty liver disease (NAFLD). The objective of this study was to inves…
View article: Kinetics of serum O‐glycosylated M‐hepatitis B surface antigen with hepatocellular carcinoma history and nucleos(t)ide analogue therapy in hepatitis B patients
Kinetics of serum O‐glycosylated M‐hepatitis B surface antigen with hepatocellular carcinoma history and nucleos(t)ide analogue therapy in hepatitis B patients Open
A newly developed O‐glycosylated M‐hepatitis B surface antigen (HBsAgGi) measurement system can detect hepatitis B surface antigen (HBsAg) associated with infectious particles. We investigated the association of HBsAgGi levels with clinica…
View article: Management of Rare Hemorrhage From Collateral Vessels During Gastrostomy Replacement Using Percutaneous Transhepatic Occlusion in Patient With Portal Hypertension
Management of Rare Hemorrhage From Collateral Vessels During Gastrostomy Replacement Using Percutaneous Transhepatic Occlusion in Patient With Portal Hypertension Open
A 51-year-old male patient with alcoholic cirrhosis visited our hospital for a scheduled gastrostomy replacement. During the gastrostomy replacement, he suddenly experienced a massive hemorrhage from the fistula site. Based on enhanced com…
View article: Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients
Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients Open
View article: Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD
Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD Open
Aim: Pemafibrate (PEM) is a novel selective peroxisome proliferator-activated receptor alpha modulator that is effective for hypertriglyceridemia accompanying non-alcoholic fatty liver disease (HTG-NAFLD). This study aimed to identify the …
View article: Splenic artery pseudoaneurysm resulting from gastric ulcer presenting acute upper gastrointestinal bleeding
Splenic artery pseudoaneurysm resulting from gastric ulcer presenting acute upper gastrointestinal bleeding Open
View article: Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients
Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients Open
Background Among several secreted glycoproteins belonging to the thrombospondin family, thrombospondin 2 (TSP2) is involved in various functions, including collagen/fibrin formation, maintenance of normal vascular density, and cell adhesio…
View article: Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report
Disseminated Carcinomatosis of Bone Marrow as the Initial Presentation of Intrahepatic Cholangiocarcinoma without Jaundice: An Autopsy Case Report Open
Disseminated carcinomatosis of the bone marrow (DCBM) is often accompanied by disseminated intravascular coagulation (DIC) and has a poor prognosis. DCBM develops most frequently in gastric cancer and is rarely associated with intrahepatic…
View article: A case of hepatitis C-related liver cirrhosis treated with lusutrombopag before coil embolization for splenic artery aneurysm
A case of hepatitis C-related liver cirrhosis treated with lusutrombopag before coil embolization for splenic artery aneurysm Open
症例は53歳，女性．両側胸水を契機にC型肝炎を背景とした非代償性肝硬変と診断された．腹部CT検査にて径25 mmの脾動脈瘤を認めたため，治療目的に当院を受診した．受診時，血小板数4.9×104/μlと減少を認めたため，ルストロンボパグの内服を行った．血小板数7.6×104/μlへの上昇を確認し，脾動脈瘤コイル塞栓術を施行した．手技による合併症やルストロンボパグによる重篤な副作用は認めずに経過した．血小板減少症を伴う慢性肝疾患症例の観血的手技施行時において，血小板輸血の代替療…
View article: The First Known Case of Liver Abscess Caused by <i>Aggregatibacter aphrophilus</i> in Japan
The First Known Case of Liver Abscess Caused by <i>Aggregatibacter aphrophilus</i> in Japan Open
A 48-year-old man presented with a sustained fever. Abdominal computed tomography revealed multilocular liver abscesses. He underwent percutaneous needle aspiration, yielding straw-colored pus. Gram staining revealed Gram-negative coccobac…
View article: Thrombotic Thrombocytopenic Purpura Treated with Rituximab Associated with Primary Sjögren's Syndrome and Primary Hypothyroidism
Thrombotic Thrombocytopenic Purpura Treated with Rituximab Associated with Primary Sjögren's Syndrome and Primary Hypothyroidism Open
A 47-year-old man was admitted to our hospital because of thrombocytopenia and consciousness disturbance. As his laboratory data showed undetectable activity of a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13 …
View article: ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review
ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review Open
A 32‐year‐old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH‐producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemi…