Tara Gomes
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View article: Patient and Prescriber characteristics associated with return to daily-dispense methadone: A multilevel cohort study
Patient and Prescriber characteristics associated with return to daily-dispense methadone: A multilevel cohort study Open
Early in the SARS-Cov-2 pandemic, modified clinical guidance recommended the provision of take-home methadone doses for those previously ineligible to facilitate social distancing. Following this change, studies reported improved treatment…
View article: Trends in prescription opioid use for pain in Canada: a population-based repeated cross-sectional study of 6 provinces
Trends in prescription opioid use for pain in Canada: a population-based repeated cross-sectional study of 6 provinces Open
Declines in initiation and overall dispensing of prescription opioids for pain between 2018 and 2022 aligned with national efforts to promote appropriate opioid prescribing for acute and chronic noncancer pain in Canada.
View article: Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study
Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study Open
Background Direct‐acting oral anticoagulants (DOACs) have largely replaced warfarin for stroke prevention in patients with atrial fibrillation, yet their population‐level impact on health outcomes and costs remains unclear. We examined whe…
View article: Evaluating regional and temporal variations in quality indicators for opioid initiation and pharmacist medication reviews in Ontario: A population-based repeated cross-sectional study
Evaluating regional and temporal variations in quality indicators for opioid initiation and pharmacist medication reviews in Ontario: A population-based repeated cross-sectional study Open
Background: Quality indicators (QIs) are measures used to evaluate quality of services but are often underused in pharmacy practice. This study examines trends in 2 established QIs in community pharmacy. Methods: We conducted a repeated cr…
View article: Trends in the dispensing of opioids for pain and concurrent benzodiazepine use among First Nations People in Ontario, Canada, from 2013 to 2021
Trends in the dispensing of opioids for pain and concurrent benzodiazepine use among First Nations People in Ontario, Canada, from 2013 to 2021 Open
Objectives To investigate dispensing trends and the characteristics of First Nations People in Ontario dispensed an opioid for pain and concurrent benzodiazepine treatment. Methods We conducted a population-based serial cross-sectional stu…
View article: Initiation and Dose of Methadone Monotherapy vs Combination Therapy, 2015 to 2023
Initiation and Dose of Methadone Monotherapy vs Combination Therapy, 2015 to 2023 Open
Importance The increased potency of the fentanyl-dominated drug supply has precipitated a shift in patient-reported opioid tolerance and methadone prescribing guidance. However, adoption of new methadone prescribing approaches remains unkn…
View article: Canadian perinatal opioid project: a protocol for a national health data system
Canadian perinatal opioid project: a protocol for a national health data system Open
Introduction Opioids are widely used during pregnancy and can lead to health complications for pregnant people, parents and their children. Yet, little is known about the long- and short-term effects of perinatal opioid exposures on health…
View article: Comparative effectiveness and safety of insulin reference biologics versus biosimilars for types 1 and 2 diabetes mellitus: Protocol for a systematic review of real-world studies
Comparative effectiveness and safety of insulin reference biologics versus biosimilars for types 1 and 2 diabetes mellitus: Protocol for a systematic review of real-world studies Open
Introduction Diabetes mellitus is characterized by insulin deficiency or resistance. The two main types of diabetes mellitus are type 1 (T1DM) and type 2 (T2DM). Insulin is the mainstay of therapy for T1DM and often the last-line therapy f…
View article: Circumstances surrounding alcohol toxicity deaths and prior pharmacotherapy for alcohol use disorder in Ontario, Canada
Circumstances surrounding alcohol toxicity deaths and prior pharmacotherapy for alcohol use disorder in Ontario, Canada Open
Introduction Despite a high prevalence of alcohol use disorder (AUD) in Canada, access to medication-based treatment remains poor. Therefore, our aim was to explore patterns of alcohol toxicity deaths in Ontario, Canada, circumstances surr…
View article: Spillover From an Intervention on Antibiotic Prescribing for Family Physicians
Spillover From an Intervention on Antibiotic Prescribing for Family Physicians Open
Importance Antibiotic audit and feedback is effective at reducing antibiotic prescribing in primary care. Objective To evaluate the spillover of an audit-and-feedback intervention originally targeted at patients aged 65 years or older on a…
View article: Circumstances surrounding opioid toxicity deaths within shelters in Ontario, Canada, before and during the COVID-19 pandemic: a population-based descriptive cross-sectional study
Circumstances surrounding opioid toxicity deaths within shelters in Ontario, Canada, before and during the COVID-19 pandemic: a population-based descriptive cross-sectional study Open
Introduction Evidence suggests growing opioid-related toxicity deaths within shelters that has been exacerbated by the COVID-19 pandemic. We sought to characterise opioid-related toxicity deaths within Ontario shelters before and during th…
View article: Retention in Opioid Agonist Therapy Among First Nations People
Retention in Opioid Agonist Therapy Among First Nations People Open
Importance First Nations people are disproportionately impacted by the opioid crisis in Canada. While many First Nation communities have expanded access to treatment, there is a need to better understand the factors associated with early d…
View article: Primary care physician characteristics associated with becoming opioid agonist treatment prescribers in British Columbia: a retrospective case-control study
Primary care physician characteristics associated with becoming opioid agonist treatment prescribers in British Columbia: a retrospective case-control study Open
Physicians who saw fewer patients and worked across fewer settings were more likely to become OAT prescribers. However, physicians in rural settings are stepping in to address unmet demand despite resource and time constraints. Understandi…
View article: Safer opioid supply and health outcomes – Authors' reply
Safer opioid supply and health outcomes – Authors' reply Open
View article: The changing role of substances: trends, characteristics of individuals and prior healthcare utilization among individuals with accidental substance-related toxicity deaths in Ontario Canada
The changing role of substances: trends, characteristics of individuals and prior healthcare utilization among individuals with accidental substance-related toxicity deaths in Ontario Canada Open
Objective To investigate trends and the circumstances surrounding fatal substance-related toxicities directly attributed to alcohol, stimulants, benzodiazepines or opioids and combinations of substances in Ontario, Canada. Methods We condu…
View article: Comparing the effects of prescribed safer opioid supply and methadone in Ontario, Canada: a population-based matched cohort study
Comparing the effects of prescribed safer opioid supply and methadone in Ontario, Canada: a population-based matched cohort study Open
Canadian Institutes of Health Research and Ontario SPOR Support Unit.
View article: Trends in the Cost and Utilization of Publicly Dispensed Respiratory Inhalers in Ontario, Canada: A Repeated Cross‐Sectional Study
Trends in the Cost and Utilization of Publicly Dispensed Respiratory Inhalers in Ontario, Canada: A Repeated Cross‐Sectional Study Open
Purpose Several new respiratory inhalers have recently entered the market, including combination therapy products and generic alternatives. Therefore, we examined the cost and utilization of publicly dispensed respiratory inhalers in Ontar…
View article: Complex decision-making of people's use of opioid agonist therapy during pregnancy: Troubling the concept of ‘non-compliance’
Complex decision-making of people's use of opioid agonist therapy during pregnancy: Troubling the concept of ‘non-compliance’ Open
Clinical guidelines strongly recommend that pregnant people with opioid use disorder be offered Opioid Agonist Therapy (OAT); however, access to and retention in substance use services are influenced by a multitude of factors. We conducted…
View article: Pathways of care following opioid overdose among people with opioid use disorder: A multilevel cohort study
Pathways of care following opioid overdose among people with opioid use disorder: A multilevel cohort study Open
The identification of factors associated with treatment initiation following overdose may be associated with promoting longer stays in hospital and enhancing accessibility in regions with less experience managing opioid overdoses.
View article: Global Trends in Analgesic Opioid Use in Pregnancy: A Retrospective Cohort Study
Global Trends in Analgesic Opioid Use in Pregnancy: A Retrospective Cohort Study Open
Background: Pain is common during pregnancy, yet there are few contemporary studies of opioid use in pregnancy. This study aimed to describe prescription analgesic opioid use during pregnancy across four regions: Oceania (New South Wales, …
View article: Association between a publicly funded universal drug program and antipsychotic and antidepressant medication dispensing to children
Association between a publicly funded universal drug program and antipsychotic and antidepressant medication dispensing to children Open
View article: O uso da ventilação não invasiva e Canula Nasal de Alto Fluxo - CNAF em pacientes adultos na unidade de terapia intensiva - UTI's
O uso da ventilação não invasiva e Canula Nasal de Alto Fluxo - CNAF em pacientes adultos na unidade de terapia intensiva - UTI's Open
View article: Impact of Policy Changes Expanding Access to Direct-Acting Antivirals on Hepatitis C Virus–Related Hospitalizations in People With HIV: A Population-Based Study
Impact of Policy Changes Expanding Access to Direct-Acting Antivirals on Hepatitis C Virus–Related Hospitalizations in People With HIV: A Population-Based Study Open
Background The burden of hepatitis C virus (HCV)–related hospitalizations is substantial, particularly among people with HIV and HCV. In Ontario, Canada, use of direct-acting antivirals (DAAs) increased following policies removing fibrosis…
View article: Trends, characteristics, and circumstances surrounding stimulant toxicity deaths in Ontario, Canada from 2018 to 2021
Trends, characteristics, and circumstances surrounding stimulant toxicity deaths in Ontario, Canada from 2018 to 2021 Open
View article: Canadian Trends in Estimated Drug Purchases and Projections: 2024 and 2025
Canadian Trends in Estimated Drug Purchases and Projections: 2024 and 2025 Open
What Is the issue? Data on trends in the pharmaceutical market remain limited. We offer an annual update on estimated drug purchases in Canada and highlight key factors that could impact future spending. What Did We do? We conducted a retr…
View article: Clinical Characteristics of Inpatients with Schizophrenia Spectrum Disorder Treated with Electroconvulsive Therapy: A Population-Level Cross-Sectional Study: Titre: Caractéristiques cliniques des patients hospitalisés présentant un trouble du spectre de la schizophrénie et traités par électrochocs : Une étude de population transversale
Clinical Characteristics of Inpatients with Schizophrenia Spectrum Disorder Treated with Electroconvulsive Therapy: A Population-Level Cross-Sectional Study: Titre: Caractéristiques cliniques des patients hospitalisés présentant un trouble du spectre de la schizophrénie et traités par électrochocs : Une étude de population transversale Open
Objective Electroconvulsive therapy (ECT) is an evidence-based treatment for schizophrenia when anti-psychotic medications do not sufficiently control symptoms of psychosis or rapid response is required. Little is known about how it is use…
View article: Frequency of supervised consumption service use and acute care utilization in people who inject drugs
Frequency of supervised consumption service use and acute care utilization in people who inject drugs Open
SCS use had little impact on objectively measured acute care utilization, which was high overall. Although preventing overdose mortality is the primary goal of SCS in Canada, resourcing sites to support their clients' acute healthcare need…
View article: A percepção do profissional da Atenção Primária frente ao paciente com transtorno mental
A percepção do profissional da Atenção Primária frente ao paciente com transtorno mental Open
Introdução: Os movimentos da reforma psiquiátrica, as lutas antimanicomial, bem como as conferências em saúde mental foram de suma importância para a inserção de uma nova percepção sobre os pacientes com transtorno mental. Mediante isso, e…
View article: The decriminalization of illicit drugs in British Columbia: a national evaluation protocol
The decriminalization of illicit drugs in British Columbia: a national evaluation protocol Open
View article: Enhancing population-level research among people who inject drugs: a validation and retrospective cohort study using health administrative data in Ontario, Canada
Enhancing population-level research among people who inject drugs: a validation and retrospective cohort study using health administrative data in Ontario, Canada Open
ObjectiveHealth administrative data can support population-level research among people who inject drugs (PWID), however these data sources remain underutilized due to the difficulty in identifying drug use in routinely collected data. We v…