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View article: Functional identification of <i>cis</i> -regulatory long noncoding RNAs at controlled false discovery rates
Functional identification of <i>cis</i> -regulatory long noncoding RNAs at controlled false discovery rates Open
A key attribute of some long noncoding RNAs (lncRNAs) is their ability to regulate expression of neighbouring genes in cis. However, such ‘cis-lncRNAs’ are presently defined using ad hoc criteria that, we show, are prone to false-positive …
View article: Author Correction: Tumour mutations in long noncoding RNAs enhance cell fitness
Author Correction: Tumour mutations in long noncoding RNAs enhance cell fitness Open
View article: Tumour mutations in long noncoding RNAs enhance cell fitness
Tumour mutations in long noncoding RNAs enhance cell fitness Open
View article: Functional identification of cis-regulatory long noncoding RNAs at controlled false-discovery rates
Functional identification of cis-regulatory long noncoding RNAs at controlled false-discovery rates Open
A key attribute of some long noncoding RNAs (lncRNAs) is their ability to regulate expression of neighbouring genes in cis. However, such ‘cis-lncRNAs’ are presently defined using ad hoc criteria that, we show, are prone to false-positive …
View article: Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities
Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities Open
View article: Tumour mutations in long noncoding RNAs enhance cell fitness
Tumour mutations in long noncoding RNAs enhance cell fitness Open
Long noncoding RNAs (lncRNAs) can act as tumour suppressor or oncogenes to contrast/promote tumour cell proliferation via RNA-dependent mechanisms. Recently, genome sequencing has identified elevated densities of tumour somatic single nucl…
View article: Tumour mutations in long noncoding RNAs enhance cell fitness
Tumour mutations in long noncoding RNAs enhance cell fitness Open
Long noncoding RNAs (lncRNAs) can act as tumour suppressors or oncogenes to repress/promote tumour cell proliferation via RNA-dependent mechanisms. Recently, genome sequencing has identified elevated densities of tumour somatic single nucl…
View article: Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities
Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities Open
Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cellular disease hallmarks remain unclear. Here we employ pooled CRISPR deletion to perturb all 831 lncRNAs in KRAS-mutant non-small cell lung c…
View article: Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening Open
View article: Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs
Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs Open
The sequence domains underlying long noncoding RNA (lncRNA) activities, including their characteristic nuclear enrichment, remain largely unknown. It has been proposed that these domains can originate from neofunctionalized fragments of tr…
View article: Scalable Design of Paired CRISPR Guide RNAs for Genomic Deletion
Scalable Design of Paired CRISPR Guide RNAs for Genomic Deletion Open
CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, to parallelized l…
View article: Scalable Design of paired CRISPR Guide RNAs for Genomic Deletion
Scalable Design of paired CRISPR Guide RNAs for Genomic Deletion Open
Using CRISPR/Cas9, diverse genomic elements may be studied in their endogenous context. Pairs of single guide RNAs (sgRNAs) are used to delete regulatory elements and small RNA genes, while longer RNAs can be silenced through promoter dele…