Taisuke Furusho
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View article: Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids
Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids Open
AAV vectors show promise for gene therapy; however, kidney gene transfer remains challenging. Here we conduct a barcode-seq-based comparison of 47 AAV capsids administered through different routes in mice, followed by individual validation…
View article: Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids
Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids Open
Despite recent remarkable advancements in adeno-associated virus (AAV) vector technologies, effective gene delivery to the kidney remains a significant challenge. Here we show that AAV vector transduction in proximal tubules and podocytes,…
View article: Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A)
Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) Open
Urinary uromodulin, secreted by renal tubular cells, protects against urinary tract infections and kidney stones. In contrast, the intracellular accumulation of uromodulin is associated with hypertension and chronic kidney disease. However…
View article: Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney
Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney Open
View article: Table of Contents
Table of Contents Open
View article: Table of Contents
Table of Contents Open
View article: WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4
WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 Open
View article: Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney
Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney Open
The sodium chloride cotransporter (NCC) has been identified as a key molecule regulating potassium balance. The mechanisms of NCC regulation during low extracellular potassium concentrations have been studied in vitro. These studies have s…