Explanipedia

Early Cancer Detection via Multi-microRNA Profiling of Urinary Exosomes Captured by Nanowires Open

Takao Yasui, Atsushi Natsume, Takeshi Yanagida, Kazuki Nagashima, Takashi Washio , et al. · 2024

Multiple microRNAs encapsulated in extracellular vesicles (EVs) including exosomes, unique subtypes of EVs, differ in healthy and cancer groups of people, and they represent a warning sign for various cancer scenarios. Since all EVs in blo…

Advances of Fluorescent Nanodiamond Platforms for Intracellular and On-Chip Biosensing Open

Taisuke Shimada, Yasuyuki Ueda, Yoshinobu Baba, Hiroshi Yukawa · 2024

Intracellular and extracellular sensing of physical and chemical variables is important for disease diagnosis and the understanding of cellular biology. Optical sensing utilizing fluorescent nanodiamonds (FNDs) is promising for probing int…

Nanomaterial-based sensors in analytical chemistry Open

Taisuke Shimada · 2024

Identifying high-grade serous ovarian carcinoma–specific extracellular vesicles by polyketone-coated nanowires Open

Akira Yokoi, Mayu Ukai, Takao Yasui, Yasuhide Inokuma, Kim Hyeon‐Deuk , et al. · 2023

Cancer cell–derived extracellular vesicles (EVs) have unique protein profiles, making them promising targets as disease biomarkers. High-grade serous ovarian carcinoma (HGSOC) is the deadly subtype of epithelial ovarian cancer, and we aime…

Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy Open

Hiromi Takahashi, Takao Yasui, Masaki Hirano, Keiko Shinjo, Yusuke Miyazaki , et al. · 2023

Cell-free DNA (cfDNA) and extracellular vesicles (EVs) are molecular biomarkers in liquid biopsies that can be applied for cancer detection, which are known to carry information on the necessary conditions for oncogenesis and cancer cell-s…

MicroRNA Extraction from Extracellular Vesicles in Body Fluids Using PMMA-based Nanowire Devices Open

Taisuke Shimada, Daiki Takeshita, Satoru Ito, Takao Yasui, Yoshinobu Baba · 2023

体液中の細胞外小胞(EVs)に内包されるmicroRNAs(miRNAs)は,低侵襲な疾病診断を可能にするバイオマーカーとしてとして期待されている.体液からのEVs分離はmiRNA解析の前処理として重要であるが,既存法は多量のサンプルが必要及び分離効率が低いという課題がある.本研究では,少量の体液からEVsを高効率に分離するための,酸化亜鉛ナノワイヤを埋め込んだ使い捨て可能なマイクロ流体デバイスを開発した.本デバイスは細胞培養上清液や体液を送液するだけでEVsを高効率に分離…

All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an ex Vivo Brain Tumor Model Open

Kunanon Chattrairat, Takao Yasui, Shunsuke Suzuki, Atsushi Natsume, Kazuki Nagashima , et al. · 2023

Extracellular vesicles (EVs) have promising potential as biomarkers for early cancer diagnosis. The EVs have been widely studied as biological cargo containing essential biological information not only from inside vesicles such as nucleic …

All-in-One Nanowire Assay System for Extracellular Vesicle Capture and Analysis from Ex Vivo Brain Tumor Model Open

Kunanon Chattrairat, Takao Yasui, Shunsuke Suzuki, Atsushi Natsume, Kazuki Nagashima , et al. · 2022

Molecular profiling of extracellular vesicles via charge-based capture using oxide nanowire microfluidics Open

Takao Yasui, Piyawan Paisrisarn, Takeshi Yanagida, Yuki Konakade, Yuta Nakamura , et al. · 2021

Extracellular vesicles (EVs) have shown promising features as biomarkers for early cancer diagnoses. The outer layer of cancer cell-derived EVs consists of organotropic metastasis-induced membrane proteins and specifically enriched proteog…

Fabrication of a Robust In2O3 Nanolines FET Device as a Biosensor Platform Open

Zetao Zhu, Takao Yasui, Quanli Liu, Kazuki Nagashima, Tsunaki Takahashi , et al. · 2021

Field-effect transistors (FETs) are attractive biosensor platforms for rapid and accurate detection of various analytes through surface immobilization of specific bio-receptors. Since it is difficult to maintain the electrical stability of…

Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs Open

Marina Musa, Takao Yasui, Zetao Zhu, Kazuki Nagashima, Miki Ono , et al. · 2021

Analysis and Survey of PM2.5 from a Biological Viewpoint at Kyushu University Ito Campus Open

K Miura, Sachiko Ide, Toyohiro Naito, Taisuke Shimada, Takao Yasui , et al. · 2020

Fine particulate matter sized 2.5 μm or less, referred to as PM2.5, causes serious air pollution in urban cities and is responsible for several health problems, such as respiratory disease and asthma in urban populations. Although seasonal…

Preparation of Horizontal Miniature TLC Developing Chamber for Ultra-thin Layer Chromatography Open

Ryunosuke Imazaki, Keita Kondoh, Natsumi Tani, Motohide Aoki, Hidetoshi Kumata , et al. · 2020

This paper describes a horizontal miniature developing chamber suitable for ultrathin layer chromatography (UTLC) and TLC-MS. The miniature developing chamber was designed by a CAD system and cut out from a PTFE block with a milling machin…

Announcements Open

Manabu Toyoshima, Xuguang Jiang, T. Ogawa, Nobutaka Hirokawa, Takeo Yoshikawa , et al. · 2020

Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO2 Nanowire Structures Formed by Bottom-Up Approaches Open

Taisuke Shimada, Takao Yasui, Akihiro Yonese, Takeshi Yanagida, Noritada Kaji , et al. · 2020

There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presen…

Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse Open

Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Masafumi Horiuchi , et al. · 2020

Engineering Nanowire-Mediated Cell Lysis for Microbial Cell Identification Open

Takao Yasui, Takeshi Yanagida, Taisuke Shimada, Kohei Otsuka, Masaki Takeuchi , et al. · 2019

Researchers have demonstrated great promise for inorganic nanowire use in analyzing cells or intracellular components. Although a stealth effect of nanowires toward cell surfaces allows preservation of the living intact cells when analyzin…

PM2.5 Particle Detection in a Microfluidic Device by Using Ionic Current Sensing Open

Taisuke Shimada, Hirotoshi Yasaki, Takao Yasui, Takeshi Yanagida, Noritada Kaji , et al. · 2018

Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer Open

Taisuke Shimada, Takao Yasui, Asami Yokoyama, Tatsuro Goda, Mitsuo Hara , et al. · 2018

Biomolecular recognition can be attained by using the self-assembled monolayer modification for capture of a target analyte on the nanowire surfaces instead of primary antibodies.

Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires Open

Takao Yasui, Takeshi Yanagida, Satoru Ito, Yuki Konakade, Daiki Takeshita , et al. · 2017

We demonstrate the first reported methodology using nanowires that unveils massive numbers of cancer-related urinary microRNAs.

Crystal phase-controlled synthesis of rod-shaped AgInTe2nanocrystals for in vivo imaging in the near-infrared wavelength region Open

Tatsuya Kameyama, Yujiro Ishigami, Hiroshi Yukawa, Taisuke Shimada, Yoshinobu Baba , et al. · 2016

Rod-shaped AgInTe2 nanocrystals (NCs) exhibiting intense near-band edge photoluminescence in the near-infrared (NIR) wavelength region, were successfully prepared by the thermal reaction of metal acetates and Te precursors in 1-dodecanethi…

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