Taiyi Wang
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View article: Identification of salvianolic acid A as an ADP receptor-selective and Gq/IP3 pathway-mediated anti-platelet component in Qishen Yiqi
Identification of salvianolic acid A as an ADP receptor-selective and Gq/IP3 pathway-mediated anti-platelet component in Qishen Yiqi Open
Background Antiplatelet therapy is crucial for preventing and treating cardio-cerebrovascular diseases. However, adverse events related to thrombosis or bleeding have been reported in instances of treatment with glycoprotein IIb/IIIa antag…
View article: Electroacupuncture at BL15 Improved Arrhythmia Induced Cardiomyopathy Associated with Restoring Disordered Conduction and Calcium Handling
Electroacupuncture at BL15 Improved Arrhythmia Induced Cardiomyopathy Associated with Restoring Disordered Conduction and Calcium Handling Open
Objective: Arrhythmia-induced cardiomyopathy (AIC) is a reversible dilated cardiomyopathy induced by rapid or irregular heartbeat. Acupuncture has a long history of use in the treatment of cardiac diseases, and Xinshu (BL15) is a key acupo…
View article: Nonsymmetric seismic moment tensors and seismic torques: Theory and application to caldera collapse earthquakes at Kīlauea Volcano in 2018
Nonsymmetric seismic moment tensors and seismic torques: Theory and application to caldera collapse earthquakes at Kīlauea Volcano in 2018 Open
View article: Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression
Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression Open
Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is inc…
View article: Altered synaptic homeostasis: a key factor in the pathophysiology of depression
Altered synaptic homeostasis: a key factor in the pathophysiology of depression Open
View article: Graph Neural Network based elastic deformation emulators for magmatic reservoirs of complex geometries
Graph Neural Network based elastic deformation emulators for magmatic reservoirs of complex geometries Open
Measurements of volcano deformation are increasingly routine, but constraining complex magma reservoir geometries via inversions of surface deformation measurements remains challenging. This is partly due to deformation modeling being limi…
View article: Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli
Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli Open
Lauric acid is a potent blocker for sodium channel NaV1.5 and alleviates arrhythmia via inhibiting INa.
View article: OCMDP: Observation-Constrained Markov Decision Process
OCMDP: Observation-Constrained Markov Decision Process Open
In many practical applications, decision-making processes must balance the costs of acquiring information with the benefits it provides. Traditional control systems often assume full observability, an unrealistic assumption when observatio…
View article: DistRL: An Asynchronous Distributed Reinforcement Learning Framework for On-Device Control Agents
DistRL: An Asynchronous Distributed Reinforcement Learning Framework for On-Device Control Agents Open
On-device control agents, especially on mobile devices, are responsible for operating mobile devices to fulfill users' requests, enabling seamless and intuitive interactions. Integrating Multimodal Large Language Models (MLLMs) into these …
View article: Dynamic Rupture Simulations of Caldera Collapse Earthquakes: Effects of Wave Radiation, Magma Viscosity, and Evidence of Complex Nucleation at Kılauea 2018
Dynamic Rupture Simulations of Caldera Collapse Earthquakes: Effects of Wave Radiation, Magma Viscosity, and Evidence of Complex Nucleation at Kılauea 2018 Open
All instrumented basaltic caldera collapses have generated M w > 5 very long period earthquakes. However, previous studies of source dynamics have been limited to lumped models treating the caldera block as rigid, leaving open questions re…
View article: Understanding the drivers of volcano deformation through geodetic model verification and validation
Understanding the drivers of volcano deformation through geodetic model verification and validation Open
View article: Dynamic rupture simulations of caldera collapse earthquakes: Effects of wave radiation, magma viscosity, and evidence of complex nucleation at Kīlauea 2018
Dynamic rupture simulations of caldera collapse earthquakes: Effects of wave radiation, magma viscosity, and evidence of complex nucleation at Kīlauea 2018 Open
All instrumented basaltic collapses generate Mw > 5 very long period earthquakes. However, previous studies of source dynamics have been limited to lumped models treating the caldera block as rigid, leaving open questions related to how ru…
View article: Multi-level advances in databases related to systems pharmacology in traditional Chinese medicine: a 60-year review
Multi-level advances in databases related to systems pharmacology in traditional Chinese medicine: a 60-year review Open
The therapeutic effects of traditional Chinese medicine (TCM) involve intricate interactions among multiple components and targets. Currently, computational approaches play a pivotal role in simulating various pharmacological processes of …
View article: Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15
Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15 Open
Background Circulation dysfunction is a major contributing factor to thrombosis in patients with atrial fibrillation (AF) for which effective interventions are lacking. Growing evidence indicates that regulating the paraventricular nucleus…
View article: Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation
Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation Open
Atrial fibrillation (AF) is the most common arrhythmia disease and is associated with several cardiovascular and cerebrovascular diseases. Consequently, the mortality rate of AF has increased in recent years. At present, the treatment of A…
View article: Exploring the mechanism of acupuncture for Parkinson's disease based on network pharmacology techniques
Exploring the mechanism of acupuncture for Parkinson's disease based on network pharmacology techniques Open
Objective: To explore the potential mechanism of action of acupuncture for Parkinson's disease using network pharmacology. Methods: Firstly, Parkinson's disease-related targets were collected from the DisGeNET disease database, followed by…
View article: Neural function of Bmal1: an overview
Neural function of Bmal1: an overview Open
Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is well-established as a major regulator of circadian rhyth…
View article: Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project
Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project Open
View article: Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project
Hindcasting injection-induced aseismic slip and microseismicity at the Cooper Basin Enhanced Geothermal Systems Project Open
There is a growing recognition that subsurface fluid injection can produce not only earthquakes, but also aseismic slip on faults. A major challenge in understanding interactions between injection-related aseismic and seismic slip on fault…
View article: Could Kılauea's 2020 Post Caldera‐Forming Eruption Have Been Anticipated?
Could Kılauea's 2020 Post Caldera‐Forming Eruption Have Been Anticipated? Open
In 2018 Kı̄lauea volcano erupted a decade's worth of basalt, given estimated magma supply rates, triggering caldera collapse. Yet, less than 2.5 years later Kı̄lauea re‐erupted. At the 2018 eruption onset, pressure within the summit reservoi…
View article: Identification of linoleic acid as an antithrombotic component of Wenxin Keli via selective inhibition of p-selectin-mediated platelet activation
Identification of linoleic acid as an antithrombotic component of Wenxin Keli via selective inhibition of p-selectin-mediated platelet activation Open
Atrial fibrillation significantly increases the risk of thromboembolism and stroke. Wenxin Keli (WXKL) is a widely used Chinese patent medicine against arrhythmia but if it has antithrombotic activity is unknown. Since platelet activation …
View article: Could Kilauea's 2020 post caldera-forming eruption have been anticipated?
Could Kilauea's 2020 post caldera-forming eruption have been anticipated? Open
In 2018 Kilauea volcano erupted a decade’s worth of basalt, given estimated magma supply rates, triggering caldera collapse. Yet, less than 2.5 years later Kilauea erupted again. At the 2018 eruption onset, the pressure within the shallow …
View article: Liquiritigenin, an active component of Xin Su Ning, inhibits hERG channel conductance in a bisigmoidal fashion
Liquiritigenin, an active component of Xin Su Ning, inhibits hERG channel conductance in a bisigmoidal fashion Open
Background and Purpose: Xin Su Ning (XSN) is a multi-herbal anti-arrhythmic medicine with strong clinical evidence endorsing its safety, tolerability and efficacy. The medicine contains over 70 identified active components, and the mechani…
View article: Physics-based model reconciles caldera collapse induced static and dynamic ground motion: application to Kīlauea 2018
Physics-based model reconciles caldera collapse induced static and dynamic ground motion: application to Kīlauea 2018 Open
Inflationary deformation and very long period (VLP) earthquakes frequently accompany basaltic caldera collapses, yet current interpretations do not reflect physically consistent mechanisms. We present a lumped parameter model accounting fo…
View article: Xin Su Ning—A Review of Basic and Clinical Pharmacology Integrated With Traditional Chinese Medicine Antiarrhythmic Theory
Xin Su Ning—A Review of Basic and Clinical Pharmacology Integrated With Traditional Chinese Medicine Antiarrhythmic Theory Open
Xin Su Ning (XSN) is a patented multicomponent medicine, which was certified in 2005 by the China State Food and Drug Administration to be produced pharmaceutically and to be used clinically. The XSN capsule was developed from an effective…
View article: Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis
Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis Open
Graphical Abstract Graphical abstract of the network meta-analysis. Note: CES-D, Center for Epidemiologic Studies Depression Scale; BDI, Beck Depression Inventory Scale; PHQ-9, the nine-Item Patient Health Questionnaire; K6, Kessler Screen…
View article: Traditional Chinese medicine in COVID-19
Traditional Chinese medicine in COVID-19 Open
View article: Post‐2018 Caldera Collapse Re‐Inflation Uniquely Constrains Kīlauea's Magmatic System
Post‐2018 Caldera Collapse Re‐Inflation Uniquely Constrains Kīlauea's Magmatic System Open
From August 2018 to May 2019, Kīlauea’s summit exhibited unique, simultaneous, inflation and deflation, apparent in both GPS time series and cumulative InSAR displacement maps. This deformation pattern provides clear evidence that the Hale…
View article: Post-2018 caldera collapse re-inflation uniquely constrains Kīlauea's magmatic system
Post-2018 caldera collapse re-inflation uniquely constrains Kīlauea's magmatic system Open
From August 2018 to May 2019, Kīlauea’s summit exhibited unique, simultaneous, inflation and deflation, apparent in both GPS time series and Small Baseline Subset (SBAS) derived cumulative InSAR displacement maps. This deformation pattern …
View article: Post-2018 caldera collapse re-inflation uniquely constrains Kīlauea's magmatic system
Post-2018 caldera collapse re-inflation uniquely constrains Kīlauea's magmatic system Open
Earth and Space Science Open Archive This work has been accepted for publication in Journal of Geophysical Research - Solid Earth. Version of RecordESSOAr is a venue for early communication or feedback before peer review. Data may be preli…