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View article: Integrative profiling of condensation-prone RNAs during early development
Integrative profiling of condensation-prone RNAs during early development Open
Complex RNA-protein networks play a pivotal role in the formation of many types of biomolecular condensates. How RNA features contribute to condensate formation, however, remains incompletely understood. Here, we integrate tailored transcr…
View article: HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution
HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution Open
The spatial organization of RNA condensates is fundamental for understanding of basic cellular functions, but may also provide pivotal insights into diseases. One of the major challenges to understanding the role of condensates is the lack…
View article: Integrative Profiling of Condensation-Prone RNAs During Early Development
Integrative Profiling of Condensation-Prone RNAs During Early Development Open
View article: Integrative profiling of condensation-prone RNAs during early development
Integrative profiling of condensation-prone RNAs during early development Open
Summary Complex RNA–protein networks play a pivotal role in the formation of many types of biomolecular condensates. How intrinsic RNA features contribute to condensate formation however remains unclear. Here, we integrate tailored transcr…
View article: From structural polymorphism to structural metamorphosis of the coat protein of flexuous filamentous potato virus Y
From structural polymorphism to structural metamorphosis of the coat protein of flexuous filamentous potato virus Y Open
The structural diversity and tunability of the capsid proteins (CPs) of various icosahedral and rod-shaped viruses have been well studied and exploited in the development of smart hybrid nanoparticles. However, the potential of CPs of the …
View article: Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation
Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation Open
View article: Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation
Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation Open
The embryonic progression from naïve to primed pluripotency is accompanied by the rapid decay of pluripotency-associated mRNAs and a concomitant radical morphogenetic sequence of epiblast polarization, rosette formation and lumenogenesis. …
View article: Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs
Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs Open
Reprogramming of somatic cells into induced Pluripotent Stem Cells (iPSCs) is a major leap towards personalized approaches to disease modelling and cell-replacement therapies. However, we still lack the ability to fully control the epigene…
View article: IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions
IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions Open
Genomic imprinting is an epigenetic phenomenon leading to parental allele-specific expression. Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for several human disorders. This unusual expression …
View article: IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions
IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions Open
Genomic imprinting is an epigenetic phenomenon leading to parental allele-specific expression. Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for several human disorders. This unusual expression …