Takaaki Hattori
YOU?
Author Swipe
View article: The glymphatic system in cerebrospinal fluid dynamics – clinical implications, its evaluation, and application to therapeutics
The glymphatic system in cerebrospinal fluid dynamics – clinical implications, its evaluation, and application to therapeutics Open
Background: The glymphatic system is a waste clearance system that facilitates the efficient removal of interstitial solutes, including neurotoxic substances such as β-amyloid, from the central nervous system. Numerous studies have highlig…
View article: Clodronate liposome treatment contributes to the nerve regeneration in corneal nerve involvement of diabetic mice
Clodronate liposome treatment contributes to the nerve regeneration in corneal nerve involvement of diabetic mice Open
The dense nerve and thin vascular structure of the corneal tissue provide the refractive function in healthy eyes. Diabetes mellitus causes ocular complications including corneal opacification because of corneal nerve degeneration. Diabeti…
View article: Lacrimal duct diseases are the potential cause of corneal epitheliopathy
Lacrimal duct diseases are the potential cause of corneal epitheliopathy Open
Purpose: The purpose of this study was to determine the frequency of corneal epitheliopathy in patients with lacrimal duct diseases and to elucidate the clinical characteristics of patients with corneal epitheliopathy. Methods: Among patie…
View article: Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage
Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage Open
Multiple sclerosis (MS) causes gait and cognitive impairments that are partially normalized by compensatory mechanisms. We aimed to identify the gait tasks that unmask gait disturbance and the underlying neural correlates in MS. We include…
View article: Programmed Cell Death-1 Pathway Deficiency Enhances Autoimmunity Leading to Dacryoadenitis of Mice
Programmed Cell Death-1 Pathway Deficiency Enhances Autoimmunity Leading to Dacryoadenitis of Mice Open
Programmed cell death protein (PD)-1 is a coinhibitory molecule that suppresses immune response and maintains immune homeostasis. Moreover, the PD-1 pathway blocks cancers from being attacked by immune cells. Anti-PD-1 antibody therapy suc…
View article: Corticosteroid eye drop instillation aggravates the development of Acanthamoeba keratitis in rabbit corneas inoculated with Acanthamoeba and bacteria
Corticosteroid eye drop instillation aggravates the development of Acanthamoeba keratitis in rabbit corneas inoculated with Acanthamoeba and bacteria Open
The role of topical corticosteroids in management of Acanthamoeba keratitis (AK) remains controversial. Using a rabbit AK model, we investigated whether corticosteroid use is a risk factor of AK. Acanthamoeba (1 × 10 5 /ml) was incubated w…
View article: P3‐072: QUANTITATIVE MEASUREMENT OF AMYLOID BETA OLIGOMER IN MOUSE BRAIN USING DOT BLOT ASSAY
P3‐072: QUANTITATIVE MEASUREMENT OF AMYLOID BETA OLIGOMER IN MOUSE BRAIN USING DOT BLOT ASSAY Open
In recent years, soluble amyloid beta oligomers (AβOs) have been considered to play an important role in synaptic failure and neurodegeneration in Alzheimer's disease (AD). Previously, it was difficult to quantify the amount of AβOs using …
View article: Traumatic globe rupture after non-Descemet’s stripping automated endothelial keratoplasty with scleral suture fixation of intraocular lens: a case report
Traumatic globe rupture after non-Descemet’s stripping automated endothelial keratoplasty with scleral suture fixation of intraocular lens: a case report Open
Background: To report the first case of traumatic globe rupture after non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with scleral suture fixation of intraocular lens (IOL). Case presentation: A 71-year old male was refe…
View article: Corneal deposits associated with topical tosufloxacin following penetrating keratoplasty: a case report
Corneal deposits associated with topical tosufloxacin following penetrating keratoplasty: a case report Open
Topical tosufloxacin treatment has the risk of precipitation on compromised corneas such as corneal grafts with epithelial defect after penetrating keratoplasty. After discontinuation of therapy, the deposit may resolve spontaneously witho…
View article: Novel Insights Into the Immunoregulatory Function and Localization of Dendritic Cells
Novel Insights Into the Immunoregulatory Function and Localization of Dendritic Cells Open
Dendritic cells (DCs) are antigen-presenting cells that normally play a critical role in stimulating T-cell-dependent immune responses. However, tolerogenic DCs (CD11cMHC-IICD80CD86) induce immune tolerance by stimulating regulatory T cell…