Takaaki Kosugi
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View article: Design and rationale for a pilot trial of D-alanine supplementation to reduce the triglyceride to high-density lipoprotein cholesterol ratio in patients with chronic kidney disease
Design and rationale for a pilot trial of D-alanine supplementation to reduce the triglyceride to high-density lipoprotein cholesterol ratio in patients with chronic kidney disease Open
This protocol was approved by the Clinical Trial Review Board of Nara Medical University Clinical Research Review Committee (CRB5200002) on February 5, 2025, and is available to the public on the website of the Japan Registry of Clinical T…
View article: Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation
Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation Open
Artificial intelligence for rare pathological lesion detection faces dual challenges: expert annotation scarcity and domain shifts across institutions. Using multi-institutional kidney biopsies from 22 hospitals with 3 scanner types (NDPI,…
View article: The Antibiotic effect of Silver CAPD Catheter on Peritoneal Dialysis-related infections (ASCA-PD) study: a multicenter randomized open-label trial protocol
The Antibiotic effect of Silver CAPD Catheter on Peritoneal Dialysis-related infections (ASCA-PD) study: a multicenter randomized open-label trial protocol Open
Background: Peritoneal dialysis (PD) offers greater flexibility than hemodialysis, especially in patients with limited mobility or demanding schedules; however, PD-related infection is a major complication and a cause of withdrawal from pe…
View article: The association between low-grade proteinuria and adverse kidney outcomes in IgA nephropathy: A systematic review and meta-analysis
The association between low-grade proteinuria and adverse kidney outcomes in IgA nephropathy: A systematic review and meta-analysis Open
Background Overt proteinuria (>1.0 g/day) is a well-established risk factor for kidney disease progression in IgA nephropathy (IgAN). However, recent evidence suggests that even low-grade proteinuria, typically defined as 0.5–1.0 g/day, ma…
View article: Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Lower eGFR Decline in Nondiabetic CKD Patients without Proteinuria
Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Lower eGFR Decline in Nondiabetic CKD Patients without Proteinuria Open
Key Points Sodium-glucose cotransporter 2 inhibitors (SGLT2is) significantly slowed chronic decline in eGFR in nondiabetic CKD patients without proteinuria. Propensity score–matched analysis confirmed that SGLT2i users had a significantly …
View article: Association between hemoglobin level and mortality in patients undergoing maintenance hemodialysis: a nationwide dialysis registry in Japan
Association between hemoglobin level and mortality in patients undergoing maintenance hemodialysis: a nationwide dialysis registry in Japan Open
Background The optimal hemoglobin (Hb) range in patients undergoing hemodialysis remains controversial. We aimed to investigate the association between Hb levels and mortality in patients undergoing hemodialysis and explore the potential f…
View article: Nutritional Status Modifies the Association Between Hemoglobin Level and Mortality in Older Patients Undergoing Hemodialysis: A Nationwide Dialysis Registry in Japan
Nutritional Status Modifies the Association Between Hemoglobin Level and Mortality in Older Patients Undergoing Hemodialysis: A Nationwide Dialysis Registry in Japan Open
Among older patients undergoing HD, the impact of Hb levels on mortality was attenuated in the high-risk NRI-JH group.
View article: Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis
Renal anemia and hyporesponsiveness to ESA for preservation of residual kidney function in patients undergoing peritoneal dialysis Open
View article: Association of body indices with mortality in older population: Japan Specific Health Checkups (J‐ <scp>SHC</scp> ) Study
Association of body indices with mortality in older population: Japan Specific Health Checkups (J‐ <span>SHC</span> ) Study Open
Background Obesity indices reflect not only fat mass but also muscle mass and nutritional status in older people. Therefore, they may not accurately reflect prognosis. This study aimed to investigate associations between a body shape index…
View article: Serum High-Density Lipoprotein Cholesterol Levels and the Risk of Kidney Function Decline: The Japan Specific Health Checkups (J‑SHC) Study
Serum High-Density Lipoprotein Cholesterol Levels and the Risk of Kidney Function Decline: The Japan Specific Health Checkups (J‑SHC) Study Open
Low HDL-C levels were associated with kidney function decline; however, high HDL-C levels were not associated with adverse kidney outcomes in the general Japanese population.
View article: Association of eGFR slopes with Cardiorenal outcomes in Chronic kidney disease patients before and after Multidisciplinary education
Association of eGFR slopes with Cardiorenal outcomes in Chronic kidney disease patients before and after Multidisciplinary education Open
Multidisciplinary education has been shown to slow the progression of chronic kidney disease (CKD) and reduce cardiovascular (CV) risk, although its effects depend partly on patient characteristics. The aim of this study was to assess how …
View article: Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: the Japan Specific Health Checkups Study
Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: the Japan Specific Health Checkups Study Open
Background Unlike systolic blood pressure (SBP), the prognostic value of diastolic blood pressure (DBP) in kidney function has not been established. We hypothesized that pulse pressure (PP), which is associated with arteriosclerosis, would…
View article: #1865 The role of osteoclast-associated receptor in phosphorus metabolism via salivary-bone-kidney interaction
#1865 The role of osteoclast-associated receptor in phosphorus metabolism via salivary-bone-kidney interaction Open
Background and Aims We have identified osteoclast-associated receptor (OSCAR) in the osteoclasts and salivary proline-rich proteins (S-PRPs), which are specifically secreted from the salivary glands and are carrier proteins for calcium and…
View article: #1548 The involvement of soluble fms-like tyrosine kinase-1 in the transition from acute kidney injury to chronic kidney disease
#1548 The involvement of soluble fms-like tyrosine kinase-1 in the transition from acute kidney injury to chronic kidney disease Open
Background and Aims Fms-like tyrosine kinase-1 (Flt-1) is a receptor for vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) and, playing a crucial role in angiogenesis and inflammation pathways. Soluble Flt-1 (sFl…
View article: Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: The Japan Specific Health Checkups (J-SHC) Study
Pulse pressure modifies the association between diastolic blood pressure and decrease in kidney function: The Japan Specific Health Checkups (J-SHC) Study Open
Background Unlike systolic blood pressure (SBP), the prognostic value of diastolic blood pressure (DBP) in kidney function has not been established. We hypothesized that pulse pressure (PP), which is associated with arteriosclerosis, would…
View article: Prevention of Contrast-Induced Nephropathy After Emergency Percutaneous Coronary Intervention With a Single Bolus Administration of High-Concentrate Sodium Bicarbonate ― Rationale and Design of a Single-Arm Study Compared With Historical Controls ―
Prevention of Contrast-Induced Nephropathy After Emergency Percutaneous Coronary Intervention With a Single Bolus Administration of High-Concentrate Sodium Bicarbonate ― Rationale and Design of a Single-Arm Study Compared With Historical Controls ― Open
Background: Contrast-induced nephropathy (CIN) is clinically important because of its poor prognosis. The incidence of CIN is higher in emergency than elective percutaneous coronary intervention (PCI) because there is no esta…
View article: Correction to: Association of initial prednisolone dose with remission, relapse, and infectious complications in adult‑onset minimal change disease
Correction to: Association of initial prednisolone dose with remission, relapse, and infectious complications in adult‑onset minimal change disease Open
View article: Association of initial prednisolone dose with remission, relapse, and infectious complications in adult-onset minimal change disease
Association of initial prednisolone dose with remission, relapse, and infectious complications in adult-onset minimal change disease Open
Background A dose of 0.5–1 mg/kg/day of prednisolone (PSL) is administered for the initial treatment of minimal change disease (MCD). However, little is known about the optimal PSL dose for the initial treatment of MCD. Methods We conducte…