Takafumi Minato
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View article: Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes
Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes Open
CNOT3 plays a protective role in ALI by suppressing expression of pro-inflammatory genes Il1b and Nos2 through both post-transcriptional and transcriptional mechanisms, including mRNA stability control of Spi1.
View article: Secondary trigeminal neuralgia caused by lung adenocarcinoma metastasis on trigeminal nerve roots successfully relieved by opioids: A case report
Secondary trigeminal neuralgia caused by lung adenocarcinoma metastasis on trigeminal nerve roots successfully relieved by opioids: A case report Open
Secondary trigeminal neuralgia (TN) is caused by identifiable diseases or lesions of the trigeminal nerve root, Gasserian ganglion and/or pons. TN is a neuropathic pain disorder characterized by electric shock-like or stabbing pain in the …
View article: Genomic analysis of Kabuki syndrome with multiple abnormalities in infancy
Genomic analysis of Kabuki syndrome with multiple abnormalities in infancy Open
Kabuki syndrome (KS) is characterized by multiple congenital anomalies and intellectual disability and is generally clinically recognizable.1 Previous studies revealed that pathogenic variants in causative genes (KMT2D, KDM6A) were found i…
View article: Investigation of the transcriptional regulation of inflammation-related genes by the CCR4-NOT complex in the pathophysiology of ARDS/Acute Lung Injury.
Investigation of the transcriptional regulation of inflammation-related genes by the CCR4-NOT complex in the pathophysiology of ARDS/Acute Lung Injury. Open
Acute respiratory distress syndrome (ARDS) is an acute lung injury with high mortality, linked to various factors like sepsis, aspiration, pneumonias, and SARS-CoV-2 infections. No effective drugs are currently available, necessitating fur…
View article: The therapeutic effect of the bacterial ACE2-like enzyme B38-CAP on ARDS/acute lung injury induced by abdominal sepsis.
The therapeutic effect of the bacterial ACE2-like enzyme B38-CAP on ARDS/acute lung injury induced by abdominal sepsis. Open
Angiotensin-converting enzyme 2 (ACE2) is the carboxypeptidase that degrades angiotensin II (Ang II) and improves the pathologies of cardiovascular disease and acute respiratory distress syndrome (ARDS)/acute lung injury. B38-CAP, a carbox…
View article: Anti-fibrotic effects of mRNA deadenylase CNOT6L in the pathogenesis of heart failure
Anti-fibrotic effects of mRNA deadenylase CNOT6L in the pathogenesis of heart failure Open
Heart failure is a leading cause of death in developed countries. The role of mRNA regulation in the pathology of heart failure remains elusive. CCR4-NOT complex is a multi-subunit protein complex constituting exonuclease-mediated degradat…
View article: ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury
ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury Open
Angiotensin-converting enzyme 2 (ACE2) is the carboxypeptidase to degrade angiotensin II (Ang II) to angiotensin 1–7 (Ang 1–7) and improves the pathologies of cardiovascular disease and acute respiratory distress syndrome (ARDS)/acute lung…
View article: Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme activity on acute lung injury in COVID-19
Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme activity on acute lung injury in COVID-19 Open
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a carboxypeptidase that degrades angiotensin II (Ang II) and thereby …
View article: ACE2-like carboxypeptidase B38-CAP suppresses severe acute lung injury induced by aspiration pneumonia and abdominal sepsis as well as SARS-CoV-2 infection
ACE2-like carboxypeptidase B38-CAP suppresses severe acute lung injury induced by aspiration pneumonia and abdominal sepsis as well as SARS-CoV-2 infection Open
Angiotensin-converting enzyme 2 (ACE2) is the carboxypeptidase to degrade angiotensin II (Ang II) to angiotensin 1–7 (Ang 1–7) and improves the pathologies of cardiovascular disease and acute respiratory distress syndrome (ARDS) / acute lu…
View article: ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury Open
View article: ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury Open
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a carboxypeptidase that degrades angiotensin II (Ang II) to angiotens…
View article: Suppression of SARS-CoV-2-induced lung injury by ACE2-like carboxypeptidase B38-CAP in COVID-19 mouse model
Suppression of SARS-CoV-2-induced lung injury by ACE2-like carboxypeptidase B38-CAP in COVID-19 mouse model Open
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is the carboxypeptidase to degrade angiotensin II (Ang II) to angiotensi…
View article: ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury Open
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is the carboxypeptidase to degrade angiotensin II (Ang II) to angiotensi…
View article: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction Open
Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a carboxypeptidase derived from Pae…
View article: Dissecting the role of CNOT6L deadenylase in pressure overload-induced cardiac fibrosis
Dissecting the role of CNOT6L deadenylase in pressure overload-induced cardiac fibrosis Open
Heart failure is a leading cause of death in developed countries. The role of mRNA regulation in the pathology of heart failure remains elusive. CCR4-NOT complex is a multi-subunit protein complex constituting exonuclease-mediated degradat…
View article: Identification of B38-CAP as an ACE2-like enzyme to suppress hypertension and cardiac dysfunction in mice.
Identification of B38-CAP as an ACE2-like enzyme to suppress hypertension and cardiac dysfunction in mice. Open
Angiotensin-converting enzyme 2 (ACE2) is a negative regulator of the renin-angiotensin system, critically involved in blood pressure regulation, heart function, lung injury, or fibrotic kidney disease. Recombinant human ACE2 protein (rhAC…
View article: Maternal Undernutrition and Breast Milk Macronutrient Content Are Not Associated with Weight in Breastfed Infants at 1 and 3 Months after Delivery
Maternal Undernutrition and Breast Milk Macronutrient Content Are Not Associated with Weight in Breastfed Infants at 1 and 3 Months after Delivery Open
This study examined whether maternal nutritional intake and breast milk macronutrient content influence the weight of breastfed infants. We investigated 129 healthy mothers with singleton babies born from July 2016 to December 2017 in a un…
View article: A bacteria-derived ACE2-like enzyme suppresses cardiac remodeling and dysfunction in mice.
A bacteria-derived ACE2-like enzyme suppresses cardiac remodeling and dysfunction in mice. Open
Angiotensin-converting enzyme 2 (ACE2) is a negative regulator of renin-angiotensin system and has the beneficial effects on the cardiovascular diseases. We elucidate that the B38-CAP, a carboxypeptidase derived from Paenibacillus sp.B38, …