Takahiro Higuchi
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View article: Conservative Management of Bowel Injury Following Renal Cryoablation: A Series of Five Cases
Conservative Management of Bowel Injury Following Renal Cryoablation: A Series of Five Cases Open
View article: Deciphering the structural impact of norepinephrine analog radiopharmaceuticals on organic cation transporter affinity
Deciphering the structural impact of norepinephrine analog radiopharmaceuticals on organic cation transporter affinity Open
This study highlights the critical influence of the compounds' chemical structure on NET and OCT affinities. Structural modifications that reduce OCT-mediated uptake while maintaining high NET affinity could improve the specificity and the…
View article: Adaptive mechanisms in pancreatic islets counteract mitochondrial dysfunction in Barth syndrome
Adaptive mechanisms in pancreatic islets counteract mitochondrial dysfunction in Barth syndrome Open
View article: Recent Advances and Future Trends of[18F]-Labeled PET Agents for Renal Imaging
Recent Advances and Future Trends of[18F]-Labeled PET Agents for Renal Imaging Open
Recent years have seen substantial advancements in renal positron emission tomography (PET) imaging. Targets for PET imaging include, but are not limited to, angiotensin receptors, norepinephrine transporters, and sodium-glucose cotranspor…
View article: Interferon gamma signaling drives cardiac metabolic rewiring
Interferon gamma signaling drives cardiac metabolic rewiring Open
Background IFN-gamma (IFN-γ) signaling influences myocardial inflammation and fibrosis across a wide range of conditions, including ischemic and non-ischemic heart failure (HF). However, the direct effects of IFN-γ on cardiomyocytes remain…
View article: Molecular Imaging of Systemic Inflammatory Response in Lymphatic Organs Provides Prognostic Value after Re-Perfused Acute Myocardial Infarction
Molecular Imaging of Systemic Inflammatory Response in Lymphatic Organs Provides Prognostic Value after Re-Perfused Acute Myocardial Infarction Open
Background Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial investigated whether molecular imaging of lymphati…
View article: Minimal invasive open tibial fracture model in mice
Minimal invasive open tibial fracture model in mice Open
Purpose Fracture models in animals are essential to analyze bone healing in musculoskeletal research fields. Especially in small animals, fractures are difficult to simulate and stabilize. Therefore, a fracture model is desirable with a sh…
View article: C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension
C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension Open
Metabolic reprogramming of vascular cells plays a crucial role in Pulmonary Arterial Hypertension (PAH), marked by a shift from oxidative phosphorylation to glycolysis (Warburg effect), altered purine biosynthesis, impaired glutaminolysis …
View article: Redefining AT1 Receptor PET Imaging: Introducing the Radiotracer [ <sup>18</sup> F]DR29
Redefining AT1 Receptor PET Imaging: Introducing the Radiotracer [ <sup>18</sup> F]DR29 Open
BACKGROUND: AT1R (angiotensin II type 1 receptors) are central to the renin-angiotensin system and are involved in regulating blood pressure and renal physiology. This study introduces [ 18 F]DR29, a fluorine-18-labeled radiotracer for pos…
View article: Molecular Glucose Imaging Reveals Network Reconfiguration by Subthalamic Deep Brain Stimulation in Parkinsonian Rats
Molecular Glucose Imaging Reveals Network Reconfiguration by Subthalamic Deep Brain Stimulation in Parkinsonian Rats Open
Background: In order to elucidate the neuromodulatory mechanisms underlying therapeutic subthalamic deep brain stimulation, we here reverse-translate a methodological pipeline that integrates neurostimulation effect parameterization and mo…
View article: Cardiac risk in recovered Covid-19 patients evaluated by 123I-mIBG
Cardiac risk in recovered Covid-19 patients evaluated by 123I-mIBG Open
View article: Reactive Turning During Walking Improves in Healthy Older Adults with a Novel Task-switching Step Exercise
Reactive Turning During Walking Improves in Healthy Older Adults with a Novel Task-switching Step Exercise Open
Purpose: Older adults often experience difficulty maintaining balance during reactive turning while walking, which can occur suddenly and unpredictably. These challenges become more pronounced when the turning direction suddenly switches f…
View article: Myeloablative Radioligand Therapy Targeting C-X-C Motif Chemokine Receptor 4 in Advanced Multiple Myeloma
Myeloablative Radioligand Therapy Targeting C-X-C Motif Chemokine Receptor 4 in Advanced Multiple Myeloma Open
Background: Markedly expressed on hematopoietic stem cells, C-X-C motif chemokine receptor 4 (CXCR4)-directed radioligand therapy (RLT) has been used in relapsed/refractory (r/r) MM to prepare for hematopoietic stem cell transplantation (H…
View article: Illuminating Cardiac Remodeling: Insights From [ <sup>18</sup> F]‐Fluorodeoxyglucose Positron Emission Tomography Imaging in Plakoglobin‐Associated Arrhythmogenic Cardiomyopathy
Illuminating Cardiac Remodeling: Insights From [ <sup>18</sup> F]‐Fluorodeoxyglucose Positron Emission Tomography Imaging in Plakoglobin‐Associated Arrhythmogenic Cardiomyopathy Open
Background Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and sudden cardiac death, along with progressive cardiac remodeling and myocardial inflammation. This study aims to elucidate…
View article: Somatostatin Receptor-Directed Theranostics in Esthesioneuroblastoma
Somatostatin Receptor-Directed Theranostics in Esthesioneuroblastoma Open
Background: We aim to report on somatostatin receptor (SSTR)-targeted molecular imaging and therapy in patients with advanced esthesioneuroblastoma (ENB). Patients and Methods: Five patients with ENB [Kadish stage D in 5/5 (100%); Hyams gr…
View article: Nomogram models for predicting outcomes in thyroid cancer patients with distant metastasis receiving 131iodine therapy
Nomogram models for predicting outcomes in thyroid cancer patients with distant metastasis receiving 131iodine therapy Open
View article: C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk
C-X-C motif chemokine receptor 4-directed PET signal in the arterial tree is not consistently linked to calcified plaque burden and cardiovascular risk Open
Purpose: To establish the extent, distribution and frequency of in-vivo vessel wall [68Ga]Ga-PentixaFor uptake and to determine its relationship with calcified atherosclerotic plaque burden (CAP) and cardiovascular risk f…
View article: Predicting pathological upstaging after radical nephroureterectomy in patients with upper tract urothelial carcinoma: results from a multicenter cohort study
Predicting pathological upstaging after radical nephroureterectomy in patients with upper tract urothelial carcinoma: results from a multicenter cohort study Open
Positive voided urine cytology and larger tumor size were significant predictors of pathological upstaging in patients with UTUC. Differences in the risk factors between renal pelvic and ureteral cancers highlight the need for tailored pre…
View article: PET imaging of sodium-glucose cotransporters (SGLTs): Unveiling metabolic dynamics in diabetes and oncology
PET imaging of sodium-glucose cotransporters (SGLTs): Unveiling metabolic dynamics in diabetes and oncology Open
SGLT-targeted PET imaging offers promising improvements in diagnostic accuracy and therapeutic planning. The findings underscore the physiological and pathological significance of SGLTs, indicating that this imaging approach could shape fu…
View article: Molecular imaging along the heart-kidney axis
Molecular imaging along the heart-kidney axis Open
Cardiorenal syndrome (CRS) involves bidirectional crosstalk between the failing heart and the kidneys. Depending on the primum movens (primary cardiac or renal injury), systems-based interactions in the secondary affected organ may …
View article: Difficulties in perceptual–motor coordination of reaching behavior in children with autism spectrum disorder
Difficulties in perceptual–motor coordination of reaching behavior in children with autism spectrum disorder Open
Increased risk of injury from collisions with objects is an important issue in children with autism spectrum disorder (ASD). The purpose of the present study was to examine whether impaired perceptual-motor coordination may underlie the hi…
View article: Rethinking Thin-Layer Chromatography for Screening Technetium-99m Radiolabeled Polymer Nanoparticles
Rethinking Thin-Layer Chromatography for Screening Technetium-99m Radiolabeled Polymer Nanoparticles Open
Thin-layer chromatography (TLC) is commonly employed to screen technetium-99m labeled polymer nanoparticle batches for unreduced pertechnetate and radio-colloidal impurities. Although this method is widely accepted, our findings applying r…
View article: Interobserver Agreement Rates on CXCR4-Directed PET/CT in Patients with Marginal Zone Lymphoma
Interobserver Agreement Rates on CXCR4-Directed PET/CT in Patients with Marginal Zone Lymphoma Open
C-X-C motif chemokine receptor 4 (CXCR4)-directed molecular imaging provides excellent read-out capabilities in patients with marginal zone lymphoma (MZL). We aimed to determine the interobserver agreement rate of CXCR4-targeted PET/CT amo…
View article: The fate of an antibody labelled with zirconium-89 in cynomolgus macaques
The fate of an antibody labelled with zirconium-89 in cynomolgus macaques Open
Background Preclinical pharmacokinetic studies of therapeutic antibodies in non-human primates are desired because of the difficulty in extrapolating ADME data from animal models to humans. We evaluated the pharmacokinetics of 89
View article: Autistic traits in neurotypical adults are related to impaired perceptual–motor coordination
Autistic traits in neurotypical adults are related to impaired perceptual–motor coordination Open
Individuals with autism spectrum disorder (ASD) are more prone to injury due to falls or collisions with objects. This may be caused by impaired perceptual–motor coordination, including inaccurate body-related spatial perception and insuff…
View article: CNP/cGMP signalling inhibits metabolic remodelling of lung pericytes from patients with pulmonary hypertension
CNP/cGMP signalling inhibits metabolic remodelling of lung pericytes from patients with pulmonary hypertension Open
Metabolic reprogramming is a fundamental hallmark of cells under various pathological conditions. In pulmonary hypertension (PH), the severe vascular remodeling is linked to metabolic dysregulation of endothelial and smooth muscle cells. T…
View article: FAPI-PET in Cardiovascular Disease
FAPI-PET in Cardiovascular Disease Open
PET probes targeting fibroblasts are frequently used for varying applications in oncology. In recent years, the clinical spectrum has been expanded towards cardiovascular medicine, e.g., after myocardial infarction, in aortic stenosis or a…
View article: Proposal of Change from SPECT to PET Aiming at Highly Reliable Diagnosis
Proposal of Change from SPECT to PET Aiming at Highly Reliable Diagnosis Open
病態に基づく早期診断は,早期の治療開始のみならず,同時に,臓器機能損失を最小限にとどめることも可能とする。核医学は機能の可視化により早期診断を可能とする手法の一つであり,中でも,single photon emission computed tomography(SPECT)による画像診断が国内では広く普及し,日本の医療を支えてきた。しかし,近年の画像診断のニーズにSPECT装置の性能は追いついていない。本稿では,これを解決する方法としてSPECTの一部をpositron …
View article: Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia
Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia Open
View article: Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies
Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies Open
Background Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for visualizing cancer-associated fibroblasts. There have also been reports suggesting incidental findings of…