Takahiro Osawa
YOU?
Author Swipe
View article: Solitary Fibrous Tumor With Doege–Potter Syndrome Successfully Treated With Preoperative Transcatheter Arterial Embolization and Complete Excision; A Case Report
Solitary Fibrous Tumor With Doege–Potter Syndrome Successfully Treated With Preoperative Transcatheter Arterial Embolization and Complete Excision; A Case Report Open
Introduction Doege–Potter syndrome (DPS) is a rare paraneoplastic phenomenon of severe hypoglycemia associated with solitary fibrous tumors (SFT). We report a case of a giant pelvic SFT with DPS, which was managed with preoperative arteria…
View article: Prognostic significance of circulating tumor DNA alterations in advanced renal cell carcinoma from SCRUM-Japan MONSTAR-SCREEN: a nationwide genomic profiling project
Prognostic significance of circulating tumor DNA alterations in advanced renal cell carcinoma from SCRUM-Japan MONSTAR-SCREEN: a nationwide genomic profiling project Open
Background Circulating tumor DNA (ctDNA) is a promising tool for diagnosing and predicting cancer prognosis. However, its clinical utility in metastatic renal cell carcinoma (mRCC) remains unclear, particularly in terms of clinical prognos…
View article: Characteristics of patients with metastatic renal cell carcinoma who do not respond to axitinib treatment
Characteristics of patients with metastatic renal cell carcinoma who do not respond to axitinib treatment Open
Background Axitinib is a widely used tyrosine kinase inhibitor (TKI) in metastatic renal cell carcinoma (mRCC) treatment. Here, we analyzed the characteristics of patients who did not respond to axitinib and evaluated alternative options f…
View article: <i>FGFR2/3</i> Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: <scp>MONSTAR</scp>‐<scp>SCREEN</scp> Database Study
<i>FGFR2/3</i> Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: <span>MONSTAR</span>‐<span>SCREEN</span> Database Study Open
Advanced/metastatic urothelial cancer (a/m UC) still has a poor prognosis despite the recent medical advances. Recent studies demonstrated that fibroblast growth factor receptor ( FGFR ) gene alterations (GAs) may be driver genes for UC; h…
View article: Strategy for reproductive and developmental toxicity (DART) studies for marketing applications in pharmaceutical development
Strategy for reproductive and developmental toxicity (DART) studies for marketing applications in pharmaceutical development Open
Studies on reproductive toxicity are conducted to assess the effects of chemicals and pharmaceuticals on the reproductive function and fetal development. However, depending on the indication or modality, Fertility and Early Embryonic Devel…
View article: VERIFICATION THE ACCURACY OF DISPLACEMENT AT CORNER REFLECTOR AND SLOPE DISPLACEMENT MONITORING BY PSInSAR ANALYSIS USING Sentinel-1 SAR DATA
VERIFICATION THE ACCURACY OF DISPLACEMENT AT CORNER REFLECTOR AND SLOPE DISPLACEMENT MONITORING BY PSInSAR ANALYSIS USING Sentinel-1 SAR DATA Open
View article: ACCURACY OF SUBSIDENCE MEASUREMENT BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA—A CASE STUDY OF SUBSIDENCE MEASUREMENT IN CHIBA PREFECTURE, JAPAN FROM 2107 TO 2024—
ACCURACY OF SUBSIDENCE MEASUREMENT BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA—A CASE STUDY OF SUBSIDENCE MEASUREMENT IN CHIBA PREFECTURE, JAPAN FROM 2107 TO 2024— Open
View article: Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project
Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project Open
View article: Primary resistance to nivolumab plus ipilimumab therapy affects second‐line treatment outcomes in patients with metastatic renal cell carcinoma
Primary resistance to nivolumab plus ipilimumab therapy affects second‐line treatment outcomes in patients with metastatic renal cell carcinoma Open
Nivolumab plus ipilimumab (NIVO+IPI) has a long‐term response rate of 30% for patients with metastatic renal cell carcinoma (mRCC). However, 20% of patients develop primary resistant disease (PRD) to NIVO+IPI and show poor survival outcome…
View article: Validation and motion analyses of laparoscopic radical nephrectomy with Thiel-embalmed cadavers
Validation and motion analyses of laparoscopic radical nephrectomy with Thiel-embalmed cadavers Open
Our aim was to develop practical training for laparoscopic surgery using Thielembalmed cadavers. Furthermore, in order to verbalize experts' motion characteristics and provide objective feedback to trainees, we initiated motion capture ana…
View article: Real-world treatment trends for patients with advanced prostate cancer and renal cell carcinoma and their cost—a survey in Japan
Real-world treatment trends for patients with advanced prostate cancer and renal cell carcinoma and their cost—a survey in Japan Open
Background Advanced (Stage IV) prostate and renal cancer have poor prognosis, and several therapies have been developed, but many are very costly. This study investigated drug regimens used in patients with untreated Stage IV prostate canc…
View article: Cross‐sectional study of therapy‐related expectations/concerns of patients with metastatic renal cell carcinoma and physicians in Japan
Cross‐sectional study of therapy‐related expectations/concerns of patients with metastatic renal cell carcinoma and physicians in Japan Open
Objective To achieve patient‐centricity in metastatic renal cell carcinoma (mRCC) treatment, it is essential to clarify the differences in perspectives between patients and physicians. This cross‐sectional analysis of a web survey aimed to…
View article: Safety and Efficacy of Cryotherapy for the Treatment of Renal Angiomyolipoma Related to Tuberous Sclerosis Complex: The Cryo-TSC Study
Safety and Efficacy of Cryotherapy for the Treatment of Renal Angiomyolipoma Related to Tuberous Sclerosis Complex: The Cryo-TSC Study Open
Purpose: Tuberous sclerosis complex (TSC) is a rare autosomal dominant inherited disease, in which approximately 60% to 80% of patients have bilateral angiomyolipoma (AML). There is a need for repeatable local treatments of TSC-AML. Cryoth…
View article: Financial Toxicity in Japanese Patients with Metastatic Renal Cell Carcinoma: A Cross-Sectional Study
Financial Toxicity in Japanese Patients with Metastatic Renal Cell Carcinoma: A Cross-Sectional Study Open
Information on the financial toxicity experienced by Japanese patients with metastatic renal cell carcinoma (mRCC) is lacking, even though Japan has its own unique public health insurance system. Thus, a web-based survey was conducted to e…
View article: A prospective study of surgeons’ workloads and associated factors in real-world practice
A prospective study of surgeons’ workloads and associated factors in real-world practice Open
New technologies such as laparoscopic and robotic surgery are spreading, and there is a demand for physicians to keep up with novel methods. In contrast to the recent focus on healthcare professional burnout, the mental and physical costs …
View article: Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project
Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project Open
View article: MONITERING EXTERNAL DISPLACEMENT OF SIX ROCKFILL DAMS BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA
MONITERING EXTERNAL DISPLACEMENT OF SIX ROCKFILL DAMS BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA Open
View article: Efficacy and safety of second-line cabozantinib after immuno-oncology combination therapy for advanced renal cell carcinoma: Japanese multicenter retrospective study
Efficacy and safety of second-line cabozantinib after immuno-oncology combination therapy for advanced renal cell carcinoma: Japanese multicenter retrospective study Open
Immuno-oncology (IO) combination therapy is utilized as a first-line systemic treatment for advanced renal cell carcinoma. However, evidence supporting the use of cabozantinib after IO combination therapy is lacking. We retrospectively ana…
View article: The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette–Guérin therapy
The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette–Guérin therapy Open
Objective Several guidelines recommended that second transurethral resection should be performed in patients with diagnosis of high-risk non-muscle-invasive bladder cancer. However, therapeutic benefits of second transurethral resection be…
View article: Cost-effectiveness analysis of cabozantinib compared with everolimus, axitinib, and nivolumab in subsequent line advanced renal cell carcinoma in Japan
Cost-effectiveness analysis of cabozantinib compared with everolimus, axitinib, and nivolumab in subsequent line advanced renal cell carcinoma in Japan Open
The treatment landscape of renal cell carcinoma has changed with the introduction of targeted therapies. While the clinical benefit of cabozantinib is well-established for Japanese patients who have received prior treatment, the economic b…
View article: Impact of postoperative complications on long-term survival in bladder cancer patients
Impact of postoperative complications on long-term survival in bladder cancer patients Open
Objective To determine the impact of postoperative complications on long-term survival outcomes in patients with bladder cancer undergoing radical cystectomy. Methods This retrospective multi-institutional study included 766 bladder cancer…
View article: Comprehensive investigation of clinicopathological and immunological features to determine prognostic impact in metastatic renal cell carcinoma: The <scp>JEWEL</scp> study
Comprehensive investigation of clinicopathological and immunological features to determine prognostic impact in metastatic renal cell carcinoma: The <span>JEWEL</span> study Open
Objectives Current prognostic models for metastatic renal cell carcinoma (mRCC) are likely inaccurate due to recent treatment advances and improved survival outcomes. The JEWEL study used a data set from patients who received tyrosine kina…
View article: Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma by the Japanese Urological Association: Summary of the update
Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma by the Japanese Urological Association: Summary of the update Open
New clinical issues have been raised through an interval of 7 years from the previous version (2016). In this study, we update the “Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma” as a 2023 vers…
View article: Real‐world effectiveness of nivolumab and subsequent therapy in Japanese patients with metastatic renal cell carcinoma (POST‐NIVO study): 36‐month follow‐up results of a clinical chart review
Real‐world effectiveness of nivolumab and subsequent therapy in Japanese patients with metastatic renal cell carcinoma (POST‐NIVO study): 36‐month follow‐up results of a clinical chart review Open
Objectives To examine the long‐term effectiveness of nivolumab monotherapy and following subsequent therapies for metastatic renal cell carcinoma (mRCC) in Japanese real‐world settings. Methods This was a multicenter, retrospective, observ…
View article: Assessment for the timing of comprehensive genomic profiling tests in patients with advanced solid cancers
Assessment for the timing of comprehensive genomic profiling tests in patients with advanced solid cancers Open
Comprehensive genomic profiling (CGP) tests have been covered by public insurance in Japan for patients with advanced solid tumors who have completed or are completing standard treatments or do not have them. Therefore, genotype‐matched dr…
View article: Final efficacy and safety results and biomarker analysis of a phase 2 study of cabozantinib in Japanese patients with advanced renal cell carcinoma
Final efficacy and safety results and biomarker analysis of a phase 2 study of cabozantinib in Japanese patients with advanced renal cell carcinoma Open
View article: METHOD AND ACCURACY OF ESTIMATING SNOW DEPTH USING SENTINEL-1 SAR DATA IN GUNMA PREFECTURE IN JAPAN
METHOD AND ACCURACY OF ESTIMATING SNOW DEPTH USING SENTINEL-1 SAR DATA IN GUNMA PREFECTURE IN JAPAN Open
Sentinel-1 SARデータを用いて,積雪深の推定方法を検討するとともに,群馬県の利根川最上流域を対象に,積雪深観測所での観測値を用いてその推定精度を検証した.本地域の森林地帯において,積雪深と斜面のVV偏波とVH偏波の後方散乱係数の関係性について検討した結果,後方散乱係数から積雪深の推定が可能であることを確認した.木が生い茂っている500m四方の斜面の後方散乱係数から4m以下の積雪深の推定精度は,推定条件などによるが20~50cm程度となり,融雪量推定のための広域な…
View article: Fatal case of subdural empyema caused by Campylobacter rectus and Slackia exigua
Fatal case of subdural empyema caused by Campylobacter rectus and Slackia exigua Open
We report a fatal subdural empyema caused by Campylobacter rectus in a 66-year-old female who developed acute onset of confusion, dysarthria, and paresis in her left extremities. A CT scan showed hypodensity in a crescentic formatio…
View article: VERIFICATION OF EXTERNAL DISPLACEMENT MONITORING OF ROCKFILL DAM BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA
VERIFICATION OF EXTERNAL DISPLACEMENT MONITORING OF ROCKFILL DAM BY PSINSAR ANALYSIS USING SENTINEL-1 SAR DATA Open
近年,人工衛星SARデータの活用については社会インフラ設備の維持管理などへの研究が進んでいるものの,恒久散乱点が得られやすいロックフィルダムにおいても,PSInSAR解析による恒久散乱点の変位の計測精度が十分に検証されているとは言い難い.本論文では,既に安定期にあるもののここ数年でも年間最大1cm程度変位しており,外部変形量を連続計測しているロックフィルダムを対象に,Sentinel-1 SARデータを活用したPSInSAR解析を実施し,測量値と解析結果を比較することにより…
View article: The development of the data correction method and feature extraction for the skill evaluation of practical laparoscopic surgical training
The development of the data correction method and feature extraction for the skill evaluation of practical laparoscopic surgical training Open
This paper describes the details of the data correction method and feature extraction for skill evaluation of practical laparoscopic surgical training. To analyze the surgical dexterity in practical laparoscopic surgical training, the moti…