Takahiro Yoshizawa
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View article: Involvement of membrane palmitoylated protein 6 (MPP6) in synapses of mouse cerebrum
Involvement of membrane palmitoylated protein 6 (MPP6) in synapses of mouse cerebrum Open
Membrane palmitoylated protein 6 (MPP6), a membrane skeletal protein, is expressed not only in the peripheral nervous system (PNS) but also in the central nervous system (CNS). In this study, we investigated the localization of MPP6 and it…
View article: Carbohydrate sulfotransferase 14 gene deletion induces dermatan sulfate deficiency and affects collagen structure and bowel contraction
Carbohydrate sulfotransferase 14 gene deletion induces dermatan sulfate deficiency and affects collagen structure and bowel contraction Open
Dermatan sulfate (DS) is a type of glycosaminoglycan present in the extracellular matrix, and which is related to tissue strength, structure, and healing. Dermatan 4- O -sulfotransferase 1 (D4ST1) is an enzyme that catalyzes the transfer o…
View article: Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
View article: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
Becker muscular dystrophy (BMD), an X-linked muscular dystrophy, is mostly caused by an in-frame deletion of Duchenne muscular dystrophy (DMD). BMD severity varies from asymptomatic to severe, associated with the genotype of DMD. However, …
View article: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
Becker muscular dystrophy (BMD), an X-linked muscular dystrophy, is mostly caused by an in-frame deletion of DMD. BMD severity varies from asymptomatic to severe, associated with the genotype of DMD. However, the underlying mechanisms rema…
View article: Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
View article: Model animals and attempts to develop therapeutic drugs for facioscapulohumeral muscular dystrophy
Model animals and attempts to develop therapeutic drugs for facioscapulohumeral muscular dystrophy Open
View article: Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Author response: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
View article: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
Becker muscular dystrophy (BMD), an X-linked muscular dystrophy, is mostly caused by an in-frame deletion of Duchenne muscular dystrophy (DMD). BMD severity varies from asymptomatic to severe, associated with the genotype of DMD. However, …
View article: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
Becker muscular dystrophy (BMD), an X-linked muscular dystrophy, is mostly caused by an in-frame deletion of DMD. BMD severity varies from asymptomatic to severe, associated with the genotype of DMD. However, the underlying mechanisms rema…
View article: Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle Open
Becker muscular dystrophy (BMD), an X-linked muscular dystrophy, is mostly caused by an in-frame deletion of DMD . BMD severity varies from asymptomatic to severe, associated with the genotype of DMD . However, the underlying mechanisms re…
View article: LGR5 Expression in Lymph Node Metastases of Colorectal Cancer: Clinicopathological Insights and Prognostic Implications
LGR5 Expression in Lymph Node Metastases of Colorectal Cancer: Clinicopathological Insights and Prognostic Implications Open
LGR5 is a promising cancer stem cell marker in colorectal cancer (CRC), and many studies have been conducted on primary tumors. However, LGR5 expression in lymph nodes has not been well studied. In this study, we identified LGR5 expression…
View article: Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families
Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families Open
The protein 4.1 and membrane palmitoylated protein (MPP) families were originally found as components in the erythrocyte membrane skeletal protein complex, which helps maintain the stability of erythrocyte membranes by linking intramembran…
View article: Upregulation of long non‑coding RNA LINC00460 in EGFR‑mutant lung cancer indicates a poor prognosis in patients treated with osimertinib
Upregulation of long non‑coding RNA LINC00460 in EGFR‑mutant lung cancer indicates a poor prognosis in patients treated with osimertinib Open
The long non-coding RNA (lncRNA) LINC00460 is involved in tumor growth, metastasis and drug resistance. The present study investigated the clinical significance of LINC00460 expression in patients with epidermal growth factor receptor (…
View article: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer Open
Background ADP-ribosylation factor-like protein 4 C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4C protein promotes cell motility, invasion, and prol…
View article: Mouse Models of Musculocontractural Ehlers-Danlos Syndrome
Mouse Models of Musculocontractural Ehlers-Danlos Syndrome Open
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is a subtype of EDS caused by mutations in the gene for carbohydrate sulfotransferase 14 (CHST14) (mcEDS-CHST14) or dermatan sulfate epimerase (DSE) (mcEDS-DSE). These mutations induce los…
View article: Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers–Danlos Syndrome
Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers–Danlos Syndrome Open
Loss-of-function mutations in carbohydrate sulfotransferase 14 (CHST14) cause musculocontractural Ehlers–Danlos syndrome-CHST14 (mcEDS-CHST14), characterized by multiple congenital malformations and progressive connective tissue fragility-…
View article: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer Open
Background: ADP-ribosylation factor-like protein 4C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4Cprotein promotes cell motility, invasion, and proli…
View article: Encouragement Award
Encouragement Award Open
View article: Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation Open
View article: A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing
A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing Open
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is caused by generalized depletion of dermatan sulfate (DS) due to biallelic pathogenic variants in CHST14 encoding dermatan 4-O-sulfotransferase 1 (D4ST1) (mcEDS-CHST14). Here, we generat…
View article: IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex
IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex Open
IQSEC2 is a guanine nucleotide exchange factor (GEF) for ADP-ribosylation factor 6 (Arf6), of which protein is exclusively localized to the postsynaptic density of the excitatory synapse. Human genome studies have revealed that the IQSEC2 …
View article: Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1
Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1 Open
Six mutations in the salt-inducible kinase 1 (SIK1)-coding gene have been identified in patients with early infantile epileptic encephalopathy (EIEE-30) accompanied by autistic symptoms. Two of the mutations are non-sense mutations that tr…
View article: Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity
Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity Open
View article: An autism-associated mutation in salt inducible kinase 1 causes repetitive behavior and social deficits due to enhanced excitatory neuronal functions in mice.
An autism-associated mutation in salt inducible kinase 1 causes repetitive behavior and social deficits due to enhanced excitatory neuronal functions in mice. Open
Background: Six mutations in the salt inducible kinase 1 (SIK1) coding gene have been identified in the early infantile epileptic encephalopathy (EIEE-30) patients accompanied by autistic symptoms, such as repetitive behavior and social be…
View article: Management, Facilities, Ethics and Welfare
Management, Facilities, Ethics and Welfare Open
Musculocontractural Ehlers-Danlos syndrome (mcEDS) is an autosomal recessive connective tissue disorder, caused by loss-of-function mutations in the carbohydrate sulfotransferase 14 gene (CHST14).Patients have serious complications such as…
View article: Disease models
Disease models Open
Transgenesis has been providing numerous models of human disease (like Alzheimer's disease) in use today.Generated through the random integration of DNA fragments into the host genome, transgenesis can lead to insertional mutagenesis if a …
View article: Systematic investigation of the skin in<i>Chst14−/−</i>mice: A model for skin fragility in musculocontractural Ehlers–Danlos syndrome caused by<i>CHST14</i>variants (mcEDS-<i>CHST14</i>)
Systematic investigation of the skin in<i>Chst14−/−</i>mice: A model for skin fragility in musculocontractural Ehlers–Danlos syndrome caused by<i>CHST14</i>variants (mcEDS-<i>CHST14</i>) Open
Loss-of-function variants in CHST14 cause a dermatan 4-O-sulfotransferase deficiency named musculocontractural Ehlers–Danlos syndrome-CHST14 (mcEDS-CHST14), resulting in complete depletion of the dermatan sulfate moiety of decorin glycosam…
View article: Drug resistance mechanisms in Japanese anaplastic lymphoma kinase‐positive non–small cell lung cancer and the clinical responses based on the resistant mechanisms
Drug resistance mechanisms in Japanese anaplastic lymphoma kinase‐positive non–small cell lung cancer and the clinical responses based on the resistant mechanisms Open
The treatment for anaplastic lymphoma kinase (ALK)‐positive lung cancer has been rapidly evolving since the introduction of several ALK tyrosine kinase inhibitors (ALK‐TKI) in clinical practice. However, the acquired resistance to these dr…
View article: Association between continuous decrease of plasma VEGF-A levels and the efficacy of chemotherapy in combination with anti-programmed cell death 1 antibody in non-small cell lung cancer patients
Association between continuous decrease of plasma VEGF-A levels and the efficacy of chemotherapy in combination with anti-programmed cell death 1 antibody in non-small cell lung cancer patients Open
Continuous decrease of plasma VEGF-A levels during treatment may be associated with the efficacy of chemo-PD1.