Explanipedia

An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure Open

J. Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi , et al. · 2021

Trk agonist drugs rescue noise-induced hidden hearing loss Open

Katharine Fernandez, Takahisa Watabe, Mingjie Tong, Xiankai Meng, Kohsuke Tani , et al. · 2020

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro…

Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress Open

Takahisa Watabe, Sho Kanzaki, Noriko Sato, Tatsuo Matsunaga, Masaaki Muramatsu , et al. · 2020

An Antibody to RGMa Promotes Regeneration of Cochlear Synapses after Noise Exposure Open

J. Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi , et al. · 2020

SUMMARY Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion. Recent work has identified the sy…

Trk Agonist Drugs Rescue Noise-Induced Hidden Hearing Loss Open

Katharine Fernandez, Takahisa Watabe, Mingjie Tong, Xiankai Meng, Kohsuke Tani , et al. · 2020

TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro…

Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients Open

Shujiro Minami, Naoki Oishi, Takahisa Watabe, Koichiro Wasano, Kaoru Ogawa · 2020

Background We reported that tinnitus patients showed reduced levels of auditory functional connectivity (FC) in comparison with normal hearing control subjects, and that we succeeded in objective diagnosis of tinnitus with 86% sensitivity …

Regulation of deafness by optogenetic stimulation of nonexcitable nonglial cells in the inner ear Open

Mitsuo Satõ, Fumiaki Nin, Masatsugu Masuda, Takahisa Watabe, Kaoru Ogawa , et al. · 2018

Background:

Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice Open

Takahisa Watabe, Ming Xu, Miho Watanabe, Junichi Nabekura, Taiga Higuchi , et al. · 2017

Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgeni…

Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear Open

Mitsuo Satõ, Taiga Higuchi, Fumiaki Nin, Genki Ogata, Seishiro Sawamura , et al. · 2017

Light-gated ion channels and transporters have been applied to a broad array of excitable cells including neurons, cardiac myocytes, skeletal muscle cells and pancreatic β-cells in an organism to clarify their physiological and pathologica…

Mitochondrial mutations in maternally inherited hearing loss Open

Hideki Mutai, Takahisa Watabe, Kenjiro Kosaki, Kaoru Ogawa, Tatsuo Matsunaga · 2017

Additional file 3: of Mitochondrial mutations in maternally inherited hearing loss Open

Hideki Mutai, Takahisa Watabe, Kenjiro Kosaki, Kaoru Ogawa, Tatsuo Matsunaga · 2017

Clinical features of probands carrying m.1555A > G or m.3243A > G. (XLSX 11 kb)

Additional file 1: of Mitochondrial mutations in maternally inherited hearing loss Open

Hideki Mutai, Takahisa Watabe, Kenjiro Kosaki, Kaoru Ogawa, Tatsuo Matsunaga · 2017

Primers used in this study. (XLSX 11Â kb)

Additional file 2: of Mitochondrial mutations in maternally inherited hearing loss Open

Hideki Mutai, Takahisa Watabe, Kenjiro Kosaki, Kaoru Ogawa, Tatsuo Matsunaga · 2017

mtDNA variants detected in 5 probands fulfilling the 5 criteria. (XLSX 12Â kb)

A Case of Middle Ear Implant VSB (Vibrant Soundbridge<sup>®</sup>) Open

Yozo Inagaki, Sho Kanzaki, Satoshi Iwasaki, Hiroyuki Yamada, Takahisa Watabe , et al. · 2016

We participated in a clinical trial for a hearing aid system in Japan, “Verification of the efficacy and safety of the middle ear implant MVS (Medel Vibrant System) in conductive and mixed hearing loss”. We present a report of a case that …

Usefulness and Limitation of Thyroglobulin Measurement in Fine Needle Aspirates (FNA-Tg) for Diagnosis of Neck Lymph Node Metastasis from Thyroid Carcinoma Open

Koji Sakamoto, Yorihisa Imanishi, Toshiki Tomita, Hiroyuki Ozawa, Yoichiro Sato , et al. · 2016

FNAC reflects whether the lesion has malignant cells, whereas FNA-Tg reflects whether the lesion has thyroid-originated tissue that specifically secrets thyroglobulin. Therefore, FNAC and FNA-Tg are considered to be complementary to each o…

A Case of Middle Ear Implant VSB (Vibrant Soundbridge<sup>®</sup>) Open

Yozo Inagaki, Sho Kanzaki, Satoshi Iwasaki, Hiroyuki YAMADA, Takahisa Watabe , et al. · 2016

We participated in a clinical trial for a hearing aid system in Japan, “Verification of the efficacy and safety of the middle ear implant MVS (Medel Vibrant System) in conductive and mixed hearing loss”. We present a report of a case that …

Development of an objective measurement method for tinnitus Open

Sho Kanzaki, Yasue Mitukura, Kei Takayama, Naoki Oishi, Hiroyuki Yamada , et al. · 2015

要旨: 目的) 簡易型脳波計測装置を用いた脳波測定によって, 耳鳴の有無を客観的に捉えられるか試みた。方法) 共著者である慶應義塾大学理工学部満倉研究室が開発した「簡易型脳波計測装置」を用いて行った。本機器で前頭前野を反映する FP1 部位のみの脳波を測定するものである。耳鳴あり, 耳鳴なし群に分けて, 30秒計測を2回測定した。得られた脳波はフーリエ変換を行い各周波数別に分けて解析した。特徴抽出手法として主成分分析を用い, クラス分類手法としてフィッシャーの線形判…

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