Explanipedia

Endoscopic findings of gallbladder lesions evaluated with image‐enhanced endoscopy: A preliminary study using resected gallbladders Open

Kiyoyuki Kobayashi, Maki Ayaki, Takako Nomura, Kaho Nakatani, Masaki Tokumo , et al. · 2025

The diagnosis of gallbladder (GB) lesions relies on imaging findings. Transpapillary cholangioscopy can potentially be used to diagnose GB lesions; however, the images obtained remain unclear. This study aimed to characterize the endoscopi…

Pericardial Effusion Causing Malignant Cardiac Tamponade After Pericardial Metastasis from an Intrahepatic Cholangiocarcinoma: Case Report Open

Takako Nomura, Kiyoyuki Kobayashi, Maki Ayaki, M Murakami, Tomohiro Ogi , et al. · 2025

Use of a Side‐Viewing Endoscope for Superficial Non‐Ampullary Duodenal Epithelial Tumors Located in the Groove Area Open

Kiyoyuki Kobayashi, Maki Ayaki, Takako Nomura, Hironobu Suto, Minoru Oshima , et al. · 2025

Efficacy of pemafibrate in metabolic dysfunction associated steatotic liver disease and metabolic dysfunction and alcohol associated steatotic liver disease with dyslipidemia: alanine aminotransferase reduction and predictive factors Open

Takako Nomura, Masafumi Ono, Kiyoyuki Kobayashi, M Murakami, Maki Ayaki , et al. · 2025

Background: Although pemafibrate has shown promise in treating metabolic dysfunction associated steatotic liver disease (MASLD), reports on its effects on metabolic dysfunction and alcohol associated steatotic liver disease (MetALD) are li…

Effectiveness of edoxaban in portal vein thrombosis associated with liver cirrhosis Open

Tomoko Tadokoro, Joji Tani, Takushi Manabe, Kei Takuma, M. Nakahara , et al. · 2024

Portal vein thrombosis (PVT) worsens the long-term prognosis of patients with cirrhosis; however, the optimal treatment remains to be determined. Reports on the efficacy of direct oral anticoagulants are increasing, and further evidence is…

Management of hepatocellular carcinoma, an important cause of death in Japanese autoimmune hepatitis patients Open

Tomoko Tadokoro, Takako Nomura, Koji Fujita, Takushi Manabe, Kei Takuma , et al. · 2024

Background Hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH) was considered rare but is increasing with prolonged prognosis. Its impact on the overall prognosis of AIH is unknown, and treatment has not been established. Aim To i…

Simple use of Y-connector for proper positioning and contrast aspiration in biliary metal stent placement Open

Kiyoyuki Kobayashi, Hideki Kobara, Takako Nomura, Tomohiro Ogi, Hideki Kamada , et al. · 2024

Endoscopic biliary drainage for unresectable malignant hilar biliary obstruction often requires multiple metal stents, and stent-in-stent placement is an effective drainage method [1] [2]. Although multiple stent placement requires more ch…

Effectiveness of Edoxaban in Portal Vein Thrombosis Associated with Liver Cirrhosis Open

Tomoko Tadokoro, Joji Tani, Takushi Manabe, Kei Takuma, M. Nakahara , et al. · 2023

Portal vein thrombosis (PVT) worsens the long-term prognosis of patients with cirrhosis; however, the optimal treatment remains to be determined. Reports on the efficacy of direct oral anticoagulants are increasing, and further evidence is…

A case of early syphilitic hepatitis that was rapidly cured by a single intramuscular injection of a continuous penicillin preparation Open

Kiyoyuki Kobayashi, Takako Nomura, Yuzuru Akaiwa, Tomohiro Ogi, Maki Ogi , et al. · 2023

症例は50歳代男性.全身倦怠感,皮膚掻痒感,褐色尿を主訴に受診し血液検査で総ビリルビンや肝胆道系酵素の上昇を認めた.肝炎ウイルスマーカーや自己抗体は陰性であった.第5病日に入院時はみられていなかった皮疹が四肢体幹に出現し,入院時の梅毒反応定性が陽性であったため,再度詳細に病歴を聴取したところ,入院2カ月前の性風俗産業利用歴が判明した.早期梅毒第2期及び早期梅毒性肝炎と診断したが,患者が近日中に転居予定で長期入院や頻回な外来通院は困難であったことから,2022年1月から本邦で…

Prognostic Value of Skeletal Muscle Loss in Patients with Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion Chemotherapy Open

Kyoko Oura, Asahiro Morishita, Joji Tani, Takako Nomura, Takushi Manabe , et al. · 2023

Sarcopenia-related factors, including the skeletal muscle index (SMI), are reportedly associated with prognosis in patients with hepatocellular carcinoma (HCC) receiving various treatments. However, there is no evidence relating to hepatic…

Cholecystocolic fistula closed using endoscopic therapy alone: A case report Open

Kiyoyuki Kobayashi, Hideki Kobara, Tomohiro Ougi, Yuzuru Akaiwa, Takako Nomura , et al. · 2022

Background: Cholecystocolic fistula (CCF) is a known but rare complication of cholelithiasis. Treatment for CCF is generally surgical. As the number of elderly patients has increased in recent years, many cases require non-surgical treatme…

Results of a survey of the Japan Society of Hepatology members -285 responses on academic, household, and social networking- Open

Hideki Fujii, Satoshi Tanaka, Ryoko Yamada, Takako Nomura, Yuji Eso , et al. · 2022

第44回日本肝臓学会西部会のキャリア支援・ダイバーシティ推進委員関連企画に先立ち,学会参加者を対象に学会,家事,SNS(Social Networking Service)に関するアンケート調査を施行し,285名から回答を得た.回答者は20歳代から80歳代までの男性244名,女性38名(不明3名)であった.「肝臓学会が以前に比し盛り上がっている」と回答した会員の割合は,39歳以下群で22%,40~49歳で6%,50~59歳で2%,60歳以上11%であった.また,家事への参加…

Efficacy of Combined Therapy with Drug-Eluting Beads-Transcatheter Arterial Chemoembolization Followed by Conventional Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Multi-Center Study Open

Asahiro Morishita, Joji Tani, Takako Nomura, Kei Takuma, M. Nakahara , et al. · 2021

EB-TACE has recently been performed because of its lower hepatotoxicity compared to cTACE in less advanced HCC. However, local recurrence at the tumor margins is often observed after DEB-TACE. cTACE involves filling the intratumoral sinuso…

Survival Benefit of Hepatic Arterial Infusion Chemotherapy over Sorafenib in the Treatment of Locally Progressed Hepatocellular Carcinoma Open

Hideki Iwamoto, Takashi Niizeki, Hiroaki Nagamatsu, Kazuomi Ueshima, Takako Nomura , et al. · 2021

BACKROUND: Not all patients with hepatocellular carcinoma (HCC) benefit from treatment with molecular targeted agents such as sorafenib. We investigated whether New-FP (fine-powder cisplatin and 5-fluorouracil), a hepatic arterial infusion…

Association between microRNA‑527 and glypican‑3 in hepatocellular carcinoma Open

Kei Nomura, Akira Kitanaka, Hisakazu Iwama, Joji Tani, Takako Nomura , et al. · 2021

The present study aimed to identify the specific microRNAs (miRNAs/miRs) and their corresponding target genes involved in hepatocellular carcinomas (HCCs). Microarray analysis was performed to examine the miRNA expression profiles of four …

Peg-IFNα-2a Contributed to HBs Antigen Seroclearance in a Patient with Chronic Hepatitis B Administered Nucleic Acid Analogs: A Three-year Follow-up Open

Tomoko Tadokoro, Koji Fujita, Kei Takuma, M. Nakahara, Kyoko Oura , et al. · 2021

We treated a 51-year-old Japanese man with chronic hepatitis B (viral load 7.6 LC/mL, genotype C). Hepatitis B virus DNA and HBe antigen were undetectable during the administration of the nucleic acid analogs (NUCs) lamivudine and adefovir…

Comprehensive analysis of circulating microRNAs as predictive biomarkers for sorafenib therapy outcome in hepatocellular carcinoma Open

Tomoki Kohno, Asahiro Morishita, Hisakazu Iwama, Koji Fujita, Joji Tani , et al. · 2020

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Clinical management has improved the prognosis of early HCC, but that of advanced HCC remains poor. Sorafenib, an oral multikinase inhibitor, prov…

Aspirin inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo via inducing cell cycle arrest and apoptosis Open

Tingting Shi, Koji Fujita, Jian Gong, M. Nakahara, Hisakazu Iwama , et al. · 2020

Aspirin, a nonsteroidal anti‑inflammatory drug (NSAID), is known to inhibit cell proliferation in a variety of cancers. However, the underlying mechanism of this inhibition remains unknown. We investigated the effects of aspirin on hepatoc…

Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro Open

Hideki Kobara, Shintaro Fujihara, Hisakazu Iwama, Takanori Matsui, Ayako Fujimori , et al. · 2020

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. The angiotensin II type 1 receptor blockers, telmisartan and candesartan, are widely used antihypertensive drugs that inhibits cancer ce…

Simple scoring system for prediction of hepatocellular carcinoma occurrence after hepatitis C virus eradication by direct‑acting antiviral treatment: All Kagawa Liver Disease Group Study Open

Joji Tani, Asahiro Morishita, Teppei Sakamoto, Kei Takuma, M. Nakahara , et al. · 2020

Direct acting antivirals (DAA) have recently been developed to treat patients with hepatitis C virus (HCV) infection, and interferon-free DAA treatment has improved the cure rate of patients. However, the occurrence rate of hepatocellular …

Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma Open

Asahiro Morishita, Koji Fujita, Hisakazu Iwama, Taiga Chiyo, Shintaro Fujihara , et al. · 2020

Hepatitis B virus (HBV)-related hepatocarcinogenesis is not necessarily associated with the liver fibrotic stage and is occasionally seen at early fibrotic stages. MicroRNAs (miRNAs) are essentially 18- to 22-nucleotide-long endogenous non…

Efficacy of combined modality therapy with sorafenib following hepatic arterial injection chemotherapy and three‑dimensional conformal radiotherapy for advanced hepatocellular carcinoma with major vascular invasion Open

Takako Nomura, Joji Tani, Akihiro Deguchi, M. Nakahara, Kyoko Oura , et al. · 2019

The prognosis of hepatocellular carcinoma (HCC) patients exhibiting macroscopic vascular invasion (MVI) is poor, and the most appropriate treatment approach remains unclear. The current study aimed to investigate the efficacy and safety of…

Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis Open

Koji Fujita, Takako Nomura, Asahiro Morishita, Tingting Shi, Kyoko Oura , et al. · 2019

Albumin–bilirubin (ALBI) grade is defined using the ALBI score, which is calculated based on total serum bilirubin and albumin. This study aimed to evaluate the diagnostic ability of the ALBI score for determining hepatic fibrosis stage an…

Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma Open

Kyoko Oura, Koji Fujita, Asahiro Morishita, Hisakazu Iwama, M. Nakahara , et al. · 2019

During diagnosis of early stage hepatocellular carcinoma (HCC), single or small lesions are difficult to identify using screening ultrasonography, and conventional tumor markers are frequently negative. MicroRNAs (miRNAs) are small non-cod…

Albumin–Bilirubin Score Differentiates Liver Fibrosis Stage and Hepatocellular Carcinoma Incidence in Chronic Hepatitis B Virus Infection: A Retrospective Cohort Study Open

Koji Fujita, Takako Nomura, Asahiro Morishita, Kyoko Oura, Hirohito Yoneyama , et al. · 2019

The albumin–bilirubin (ALBI) score was originally established to stratify prognosis in patients with cirrhosis. The diagnostic accuracy of ALBI score in liver fibrosis staging in patients with chronic hepatitis B remains to be investigated…

Albumin–bilirubin score indicates liver fibrosis staging and prognosis in patients with chronic hepatitis C Open

Koji Fujita, Kyoko Oura, Hirohito Yoneyama, Tingting Shi, Kei Takuma , et al. · 2019

Aim Albumin–bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It was defined using the ALBI score calculated based on serum total bilirubin and albumin, which represent liver function. The diagnostic …

Fibrosis Staging Using Direct Serum Biomarkers is Influenced by Hepatitis Activity Grading in Hepatitis C Virus Infection Open

Koji Fujita, Noriyuki Kuroda, Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro , et al. · 2018

Background: Chronic liver diseases (CLDs) generally progress from inflammation to fibrosis and finally to carcinogenesis. Staging of liver fibrosis progression is inevitable for the management of CLD patients. The purpose of this study was…

Circulating microRNA-636 is associated with the elimination of hepatitis C virus by ombitasvir/paritaprevir/ritonavir Open

Asahiro Morishita, Hirohito Yoneyama, Hisakazu Iwama, Koji Fujita, Miwako Watanabe , et al. · 2018

Hepatitis C virus (HCV) infection causes sustained inflammation and fibrosis. Several oral direct-acting antivirals (DAAs) including ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) were recently developed for HCV elimination. The combination…

Serum miRNAs Predicting Sustained HBs Antigen Reduction 48 Weeks after Pegylated Interferon Therapy in HBe Antigen-Negative Patients Open

Koji Fujita, Shima Mimura, Hisakazu Iwama, M. Nakahara, Kyoko Oura , et al. · 2018

The therapeutic goal for hepatitis B virus (HBV) infection is HBs antigen (HBsAg) seroclearance, which is achieved through 48-week pegylated interferon (Peg-IFN) therapy. This study aimed to identify predictive biomarkers for sustained HBs…

Grazoprevir/elbasvir treatment for the relapse of HCV genotype 1b infection after ledipasvir/sofosbuvir: A case report Open

Tomoko Tadokoro, Asahiro Morishita, Kyoko Oura, Koji Fujita, Shima Mimura , et al. · 2018

The treatment of chronic hepatitis C has radically changed due to the development of direct-acting antiviral agents (DAAs). Twelve-week treatment with ledipasvir and sofosbuvir (LDV/SOF), a combination of DAAs, is highly effective in patie…

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