Takanaga Shirai
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View article: Maslinic Acid Supplementation Suppressed Early Onset Muscle Soreness and Systemic Fatigue after Full Marathon: A Randomized, Double-Blind, Placebo-Controlled Trial
Maslinic Acid Supplementation Suppressed Early Onset Muscle Soreness and Systemic Fatigue after Full Marathon: A Randomized, Double-Blind, Placebo-Controlled Trial Open
Completing a full marathon not only causes muscle soreness and fatigue but also increases damage markers in the blood. Supplementary strategies can be used to reduce these effects. In a previous study, we focused on maslinic acid (MA), whi…
View article: Combined effects of mechanical overload and high‐intensity interval training on skeletal muscle hypertrophy in male mice
Combined effects of mechanical overload and high‐intensity interval training on skeletal muscle hypertrophy in male mice Open
Athletes often perform concurrent training that combines different exercise modalities. It is believed that muscle hypertrophic adaptation is inhibited by endurance exercise; however, the molecular mechanisms underlying the effects of high…
View article: Functional compounds oleuropein and hydroxytyrosol in olive leaves attenuate chronic kidney disease-induced muscle atrophy
Functional compounds oleuropein and hydroxytyrosol in olive leaves attenuate chronic kidney disease-induced muscle atrophy Open
View article: Development of Detection Method Using Dried Blood Spot with Next-Generation Sequencing and LabDroid for Gene Doping Control
Development of Detection Method Using Dried Blood Spot with Next-Generation Sequencing and LabDroid for Gene Doping Control Open
In recent years, as gene therapy technology has rapidly developed, there has been growing concern that it could be misused by athletes as a means of doping. However, current testing methods for gene doping have a range of limitations and r…
View article: Exercise modality‐dependent mitochondrial respiratory capacity in satellite cells and conditioned serum‐induced responses in cultured myotubes
Exercise modality‐dependent mitochondrial respiratory capacity in satellite cells and conditioned serum‐induced responses in cultured myotubes Open
Exercise‐induced mitochondrial adaptations contribute to muscle function and metabolic health. We aimed to investigate the association of moderate‐intensity swimming (MOD) and high‐intensity interval training (HIIT) with mitochondrial func…
View article: Transcriptomic responses of equine skeletal muscle to acute exercise in a hot environment
Transcriptomic responses of equine skeletal muscle to acute exercise in a hot environment Open
Exercise in hot environments raises pulmonary artery temperature to a greater extent than in cool environments in horses. Pathway analysis of RNA-seq revealed expression of genes related to response to temperature stimulus was upregulated …
View article: Systemic effect of combined functional overload and endurance-type swimming exercise on whole body metabolism in mice
Systemic effect of combined functional overload and endurance-type swimming exercise on whole body metabolism in mice Open
This study provides novel insights into the mechanisms underlying the interference effect that occurs in concurrent training, highlighting the potential systemic benefits of combining resistance and endurance exercises. Despite a reduction…
View article: Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non‐stimulated contralateral leg
Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non‐stimulated contralateral leg Open
Electrical stimulation is widely used to investigate localised muscle adaptations, with applications in both sports and rehabilitation. However, the systemic effects of electrical stimulation, particularly in the contralateral muscles that…
View article: Effect of spermidine intake on overload‐induced skeletal muscle hypertrophy in male mice
Effect of spermidine intake on overload‐induced skeletal muscle hypertrophy in male mice Open
Skeletal muscles exhibit high plasticity, such as overload‐induced hypertrophy or immobilization‐induced atrophy. During sports, skeletal muscle hypertrophy is induced by training to improve performance. Spermidine is a type of polyamine a…
View article: Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers
Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers Open
Skeletal muscle is composed of diverse cell types, including myofibers. In this study, we investigated how acute endurance exercise could induce signaling protein phosphorylation and abundance alterations using protein lysate extracted fro…
View article: Effect of spermidine intake on skeletal muscle regeneration after chemical injury in male mice
Effect of spermidine intake on skeletal muscle regeneration after chemical injury in male mice Open
Skeletal muscle has a high regenerative ability and maintains homeostasis by rapidly regenerating from frequent damage caused by intense exercise or trauma. In sports, skeletal muscle damage occurs frequently due to intense exercise, so pr…
View article: Effects of maslinic acid supplementation on exercise-induced inflammation and oxidative stress in water polo athletes: A randomized, double-blind, crossover, and placebo-controlled trial
Effects of maslinic acid supplementation on exercise-induced inflammation and oxidative stress in water polo athletes: A randomized, double-blind, crossover, and placebo-controlled trial Open
These findings suggest that MA intake not only reduces perceptual fatigue and muscle soreness but also decreases inflammation and oxidative stress in the blood and skeletal muscle.
View article: Combined effects of functional overload and denervation on skeletal muscle mass and its regulatory proteins in mice
Combined effects of functional overload and denervation on skeletal muscle mass and its regulatory proteins in mice Open
Skeletal muscle is a highly pliable tissue and various adaptations such as muscle hypertrophy or atrophy are induced by overloading or disuse, respectively. However, the combined effect of overloading and disuse on the quantitative adaptat…
View article: Maslinic Acid Enhances mTOR Signaling Activity After Acute Resistance Exercise in Mouse Skeletal Muscle
Maslinic Acid Enhances mTOR Signaling Activity After Acute Resistance Exercise in Mouse Skeletal Muscle Open
Background: Maslinic acid (MA) is an olive-derived extract with the structure of pentacyclic triterpenes, which potents anti-inflammatory effects. It has been reported that the combination of MA and resistance exercise increases skeletal m…
View article: Effects of lactate administration on hypertrophy and <scp>mTOR</scp> signaling activation in mouse skeletal muscle
Effects of lactate administration on hypertrophy and <span>mTOR</span> signaling activation in mouse skeletal muscle Open
Lactate is a metabolic product of glycolysis and has recently been shown to act as a signaling molecule that induces adaptations in oxidative metabolism. In this study, we investigated whether lactate administration enhanced muscle hypertr…
View article: Effects of exercise intensity on white adipose tissue browning and its regulatory signals in mice
Effects of exercise intensity on white adipose tissue browning and its regulatory signals in mice Open
Adipose tissue has been classified into white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue the latter of which is produced as WAT changes into BAT due to exposure to cold temperature or exercise. In response t…
View article: Maslinic Acid Promotes Hypertrophy Induced by Functional Overload in Mouse Skeletal Muscle
Maslinic Acid Promotes Hypertrophy Induced by Functional Overload in Mouse Skeletal Muscle Open
Nutritional supplements are sometimes important for athletes to improve their sports performance and maintain their condition. Maslinic acid (MA) is a type of compound with a pentacyclic triterpene structure extracted from olives, and has …
View article: Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy
Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy Open
Mechanistic/mammalian target of rapamycin (mTOR) is a central factor of protein synthesis signaling and plays an important role in the resistance training-induced increase in skeletal muscle mass and subsequent skeletal muscle hypertrophy …
View article: Effect of the order of concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle
Effect of the order of concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle Open
Athletes train to improve strength and endurance to demonstrate maximum performance during competitions. Training methods vary but most focus on strength, endurance, or both. Concurrent training is a combination of two different modes of t…
View article: Effect of lactate administration on mouse skeletal muscle under calorie restriction
Effect of lactate administration on mouse skeletal muscle under calorie restriction Open
View article: Effect of endurance exercise duration on muscle hypertrophy induced by functional overload
Effect of endurance exercise duration on muscle hypertrophy induced by functional overload Open
For many ball games, both resistance and endurance training are necessary to improve muscle strength and endurance capacity. Endurance training has been reported to inhibit muscle strength and hypertrophy, but some studies have reported th…
View article: Denervation‐induced muscle atrophy suppression in renalase‐deficient mice via increased protein synthesis
Denervation‐induced muscle atrophy suppression in renalase‐deficient mice via increased protein synthesis Open
Denervation-induced muscle atrophy increases signaling through both protein degradation and synthesis pathways. Renalase is a flavin adenine dinucleotide-dependent amine oxidase that inhibits apoptosis and inflammation and promotes cell su…
View article: The order of concurrent training affects mTOR signaling but not mitochondrial biogenesis in mouse skeletal muscle
The order of concurrent training affects mTOR signaling but not mitochondrial biogenesis in mouse skeletal muscle Open
Concurrent training involves a combination of two different modes of training. In this study, we conducted an experiment by combining resistance and endurance training. The purpose of this study was to investigate the influence of the orde…
View article: The effect of maslinic acid supplementation during training period on subjective fatigue and muscle soreness in athletes: A randomized, double-blind, cross-over, and placebo-controlled trial
The effect of maslinic acid supplementation during training period on subjective fatigue and muscle soreness in athletes: A randomized, double-blind, cross-over, and placebo-controlled trial Open