Takashi Ishikawa
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View article: DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer
DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer Open
Intratumoral genomic heterogeneity (ITGH), the existence of genotypic and phenotypic variation within an individual tumor, is known to be a key mechanism in treatment resistance. Deviating gene Expression Profiling Tumor Heterogeneity 2 (D…
View article: Hsa-miR-155-5p expression in primary breast tissue may have the potential for prediction of breast cancer brain recurrence: results from the multi-institutional exploratory cohort study
Hsa-miR-155-5p expression in primary breast tissue may have the potential for prediction of breast cancer brain recurrence: results from the multi-institutional exploratory cohort study Open
View article: Invasive Lobular Carcinoma Has Higher Immune Response Than Invasive Ductal Carcinoma in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers
Invasive Lobular Carcinoma Has Higher Immune Response Than Invasive Ductal Carcinoma in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers Open
ILC has higher immune response and immune cell infiltration than IDC in the luminal subtype.
View article: Electronic Patient-Reported Outcomes With Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy
Electronic Patient-Reported Outcomes With Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy Open
Importance Patients with ERBB2 (formerly HER2 or HER2/neu)-positive metastatic breast cancer (MBC) receiving trastuzumab deruxtecan (T-DXd), a new standard of care, may experience specific adverse events affecting their quality of life (QO…
View article: Effects of dietary nucleotide and yeast extract supplementation on survival, growth, and post-metamorphic spinal deformities in Japanese eel Anguilla japonica from the leptocephalus to glass eel stage [Aquacult. Rep. 43 (2025) 103013]
Effects of dietary nucleotide and yeast extract supplementation on survival, growth, and post-metamorphic spinal deformities in Japanese eel Anguilla japonica from the leptocephalus to glass eel stage [Aquacult. Rep. 43 (2025) 103013] Open
View article: Effects of dietary nucleotide and yeast extract supplementation on survival, growth, and post-metamorphic spinal deformities in Japanese eel Anguilla japonica from the leptocephalus to glass eel stage
Effects of dietary nucleotide and yeast extract supplementation on survival, growth, and post-metamorphic spinal deformities in Japanese eel Anguilla japonica from the leptocephalus to glass eel stage Open
This study assessed the effects of dietary nucleotide (NT) and yeast extract supplementation on the survival, growth, and post-metamorphic spinal deformities of Japanese eel (Anguilla japonica) from leptocephalus to glass eel stages. Four …
View article: Correction: From waste to feed: in vitro assessment of spent silkworm by-products and manure-raised housefly as soybean meal substitutes in ruminant feed
Correction: From waste to feed: in vitro assessment of spent silkworm by-products and manure-raised housefly as soybean meal substitutes in ruminant feed Open
View article: Clinical Significance of HER2-low Expression in Triple-negative Breast Cancer: A Retrospective Multicenter Study.
Clinical Significance of HER2-low Expression in Triple-negative Breast Cancer: A Retrospective Multicenter Study. Open
Although the HER2-low and HER2-null tumor groups among TNBC showed no significant differences in response to neoadjuvant chemotherapy or patient outcomes, the higher proliferative activity and differing outcome trends in HER2-null tumors s…
View article: Surgical Site Infection Owing to Mycobacterium mageritense After Immediate Breast Reconstruction Using a Deep Inferior Epigastric Perforator Flap
Surgical Site Infection Owing to Mycobacterium mageritense After Immediate Breast Reconstruction Using a Deep Inferior Epigastric Perforator Flap Open
Summary: Mycobacterium mageritense is a rare, rapidly growing, nontuberculosis mycobacterium that belongs to type IV of the rapidly growing mycobacteria. These bacteria are found in soil and water, and cause localized skin and soft tissue …
View article: Structural analysis of a micron-sized deposit of Cu0 in an insulin ball from a person with diabetes
Structural analysis of a micron-sized deposit of Cu0 in an insulin ball from a person with diabetes Open
The largest amount of Cu0 found in living things is in a human. Our discovery of 100 µm Cu0 within the insulin ball supports the idea that insulin preparations from outside can disrupt the balance of metals, including…
View article: Should All Low-Grade Ductal Carcinoma <i>In Situ</i> Be Excised? Implications and Challenges of the COMET Trial
Should All Low-Grade Ductal Carcinoma <i>In Situ</i> Be Excised? Implications and Challenges of the COMET Trial Open
View article: Assessing the Reliability and Validity of Principles for Health-Related Information on Social Media (PRHISM) for Evaluating Breast Cancer Treatment Videos on YouTube: Instrument Validation Study
Assessing the Reliability and Validity of Principles for Health-Related Information on Social Media (PRHISM) for Evaluating Breast Cancer Treatment Videos on YouTube: Instrument Validation Study Open
Background There is breast cancer–related medical information on social media, but there is no established method for objectively evaluating the quality of this information. Principles for Health-Related Information on Social Media (PRHISM…
View article: Breast cancer risk assessment based on a predictive model: evaluation of risk factors among Japanese women
Breast cancer risk assessment based on a predictive model: evaluation of risk factors among Japanese women Open
View article: Activity-Regulated Cytoskeleton-Associated Protein Gene Expression Is Associated With High Infiltration of Stromal Cells and Immune Cells, but With Less Cancer Cell Proliferation and Better Overall Survival in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers
Activity-Regulated Cytoskeleton-Associated Protein Gene Expression Is Associated With High Infiltration of Stromal Cells and Immune Cells, but With Less Cancer Cell Proliferation and Better Overall Survival in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers Open
ARC gene expression was associated with less cancer cell proliferation, high infiltration of stromal cells and immune cells, and better survival in the ER+/HER2- but not TNBC subtype.
View article: A Case of Occult Breast Cancer Diagnosed during Immune Checkpoint Inhibitor Treatment for Recurrent Metastatic Lung Cancer
A Case of Occult Breast Cancer Diagnosed during Immune Checkpoint Inhibitor Treatment for Recurrent Metastatic Lung Cancer Open
This case illustrates that axillary lymphadenopathy during treatment for another malignancy may represent a 2nd primary cancer such as OBC. As ICI therapy prolongs survival, clinicians should pay attention for new malignancies, including b…
View article: Data-Driven Optimization of Diet Formulation to Enhance Survival and Growth in Japanese Eel (Anguilla Japonica) Larvae
Data-Driven Optimization of Diet Formulation to Enhance Survival and Growth in Japanese Eel (Anguilla Japonica) Larvae Open
View article: Successful Management of Occult Breast Cancer with a Background of Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Pneumonia: A Case Report
Successful Management of Occult Breast Cancer with a Background of Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Pneumonia: A Case Report Open
This case highlights the successful management of triple-negative breast cancer under the constraints of anti-MDA5 antibody-positive associated interstitial pneumonia. To ensure the smooth implementation of breast cancer treatment while co…
View article: Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy
Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy Open
The standard treatment for hormone receptor-positive breast cancer in good general condition is curative surgery followed by endocrine therapy. However, for older patients, endocrine therapy alone is sometimes chosen instead of curative su…
View article: DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer
DEPTH2 score was associated with cell proliferation and immune cell infiltrations but not with systemic treatment response in breast cancer Open
Intratumoral genomic heterogeneity (ITGH), the existence of genotypic and phenotypic variation within an individual tumor, is known to be a key mechanism in treatment resistance. Deviating gene Expression Profiling Tumor Heterogeneity 2 (D…
View article: Investigation of risk factors associated with the development of depressive symptoms in healthy subjects exposed to long‐term stress: A prospective study of the Japanese Antarctic research expedition wintering party
Investigation of risk factors associated with the development of depressive symptoms in healthy subjects exposed to long‐term stress: A prospective study of the Japanese Antarctic research expedition wintering party Open
Background Stressors induce depression together with parenting experienced in childhood, personality traits, and sleep. In this study, we investigated factors associated with the development of depression in a long‐term stressful environme…
View article: Comparison of the Mitotic Count With Various Proliferative Markers for the Effective Differentiation of Benign, Borderline, and Malignant Phyllodes Tumors
Comparison of the Mitotic Count With Various Proliferative Markers for the Effective Differentiation of Benign, Borderline, and Malignant Phyllodes Tumors Open
View article: Breast cancer in adolescents and young adults has a specific biology and poor patient outcome compared with older patients
Breast cancer in adolescents and young adults has a specific biology and poor patient outcome compared with older patients Open
ER-positive/HER2-negative BC in AYA was highly proliferative with high immune cell infiltration compared with the other age groups.
View article: Attempt to Substitute the Oncotype DX Breast Recurrence Score® Test by Histopathological Factors and MUC1 Protein Expression
Attempt to Substitute the Oncotype DX Breast Recurrence Score® Test by Histopathological Factors and MUC1 Protein Expression Open
Background/Aim: Oncotype DX Breast Recurrence Score® test (ODx) is a gene profiling assay predicting the benefit of adjuvant chemotherapy for early-stage hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-ne…
View article: Transcriptome analysis of the Japanese eel (Anguilla japonica) during larval metamorphosis
Transcriptome analysis of the Japanese eel (Anguilla japonica) during larval metamorphosis Open
View article: CD8-positive T cells are key immune cells for predicting the therapeutic effect of neoadjuvant chemotherapy in triple-negative breast cancer
CD8-positive T cells are key immune cells for predicting the therapeutic effect of neoadjuvant chemotherapy in triple-negative breast cancer Open
Background Patients with triple-negative breast cancer who obtain a pathological complete response after neoadjuvant chemotherapy have an improved prognosis. The existence of tumour-infiltrating lymphocytes (TILs) in breast cancer is also …
View article: Breast cancer in Adolescent &amp; Young Adult (AYA) has a specific biology and poor patient outcome compared to older patients
Breast cancer in Adolescent & Young Adult (AYA) has a specific biology and poor patient outcome compared to older patients Open
Background We aimed to clarify the features of adolescents and young adults (AYA: younger than 40yo) breast cancer (BC) compared with other age groups in ER-positive/HER2-negative BC, given the effects of age-related hormonal status. Metho…
View article: Emerging measurements for tumor-infiltrating lymphocytes in breast cancer
Emerging measurements for tumor-infiltrating lymphocytes in breast cancer Open
Tumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers …
View article: Effectiveness of <scp>SCAR‐Q</scp> for assessment of incisional SCAR after implant‐based reconstruction in breast cancer patients: Can it be a tool for incision selection?
Effectiveness of <span>SCAR‐Q</span> for assessment of incisional SCAR after implant‐based reconstruction in breast cancer patients: Can it be a tool for incision selection? Open
Incisional scarring is a factor of cosmetic appearance evaluated after breast reconstruction, along with the shape, position, and size of the breast. This study aimed to examine the effect of the incision scar location on patient satisfact…
View article: Delayed breast reconstruction with autologous free flap after radiation therapy: Vascular complications and aesthetic outcomes
Delayed breast reconstruction with autologous free flap after radiation therapy: Vascular complications and aesthetic outcomes Open
Background The safety and outcome of breast reconstruction after radiotherapy are controversial, and the aesthetic aspects have not been studied extensively. We compared the results of vascular anastomosis, the incidence of postoperative c…
View article: Risk factors for death from other diseases after curative gastrectomy and lymph node dissection for gastric cancer
Risk factors for death from other diseases after curative gastrectomy and lymph node dissection for gastric cancer Open
Background Recent advances in treatment are expected to bring a cure to more patients with gastric cancer (GC). Focusing on the risk of death from other diseases (DOD) has become a crucial issue in patients cured of GC. The aim of this stu…