Takashi Jin
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View article: Goniometric Examination of Diffuse Reflectance of a Skin Phantom in the Wavelength Range from 400 to 1600 nm
Goniometric Examination of Diffuse Reflectance of a Skin Phantom in the Wavelength Range from 400 to 1600 nm Open
Since all of noninvasive optical monitors such as near-infrared spectroscopy are transcutaneous, it is important to consider the optical properties of the skin. The purpose of the present study was to clarify the effects of incident angle …
View article: In Vitro and In Vivo Fluorescence Imaging of Antibody–Drug Conjugate-Induced Tumor Apoptosis Using Annexin V–EGFP Conjugated Quantum Dots
In Vitro and In Vivo Fluorescence Imaging of Antibody–Drug Conjugate-Induced Tumor Apoptosis Using Annexin V–EGFP Conjugated Quantum Dots Open
Antibody-drug conjugates (ADCs) are conjugates of a monoclonal antibody and a cytotoxic drug that induce tumor apoptosis. The evaluation of ADC-induced tumor apoptosis is crucial for the development of ADCs for cancer therapy. To evaluate …
View article: Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice
Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice Open
The labelling of annexin V with indocyanine green (ICG) and π-conjugation extended ICG (ICG-C11) resulted in SWIR emitting probes that enable high-contrast molecular imaging of tumor apoptosis in living mice.
View article: Monte Carlo Modeling of Shortwave-Infrared Fluorescence Photon Migration in Voxelized Media for the Detection of Breast Cancer
Monte Carlo Modeling of Shortwave-Infrared Fluorescence Photon Migration in Voxelized Media for the Detection of Breast Cancer Open
Recent progress regarding shortwave-infrared (SWIR) molecular imaging technology has inspired another modality of noninvasive diagnosis for early breast cancer detection in which previous mammography or sonography would be compensated. Alt…
View article: Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours
Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours Open
We present indocyanine green (ICG)-based shortwave-infrared (SWIR) fluorescence molecular imaging for the highly-sensitive optical detection of breast and skin tumours in mice.
View article: Monte Carlo Modeling of Near-infrared Fluorescence Photon Migration in Breast Tissue for Tumor Prediction
Monte Carlo Modeling of Near-infrared Fluorescence Photon Migration in Breast Tissue for Tumor Prediction Open
Breast cancer is one of the most common types of cancer in Japanese women. To address the low spatial resolution challenges associated with mammography and ultrasonography, we focused on the potential of using fluorescence to observe cellu…
View article: Dual-colour (near-infrared/visible) emitting annexin V for fluorescence imaging of tumour cell apoptosis <i>in vitro</i> and <i>in vivo</i>
Dual-colour (near-infrared/visible) emitting annexin V for fluorescence imaging of tumour cell apoptosis <i>in vitro</i> and <i>in vivo</i> Open
Indocyanine green labeled recombinant annexin V probes (ICG–EGFP–Annexin V and ICG–mPlum–Annexin V) were synthesized for near-infrared and visible fluorescence imaging of tumor cell apoptosis both in vitro and in vivo.
View article: Near-infrared fluorescent protein and bioluminescence-based probes for high-resolution <i>in vivo</i> optical imaging
Near-infrared fluorescent protein and bioluminescence-based probes for high-resolution <i>in vivo</i> optical imaging Open
This review presents the recent progress on NIR fluorescent protein and bioluminescence-based probes with high-resolution in vivo imaging techniques.
View article: BRET based dual-colour (visible/near-infrared) molecular imaging using a quantum dot/EGFP–luciferase conjugate
BRET based dual-colour (visible/near-infrared) molecular imaging using a quantum dot/EGFP–luciferase conjugate Open
A bioluminescent dual-colour molecular-imaging probe was prepared to emit green and near-infrared luminescence from a conjugate between enhanced green fluorescent protein (EGFP), Renilla luciferase (RLuc) and CdSeTe/CdS quantum dot (QD).
View article: Monte Carlo Evaluation of <i>In Vivo</i> Neuroimaging Using Quantum Dots with Fluorescence in the Second Window of Near Infrared Region
Monte Carlo Evaluation of <i>In Vivo</i> Neuroimaging Using Quantum Dots with Fluorescence in the Second Window of Near Infrared Region Open
Recent advances in in vivo neuroimaging have encouraged the development of noninvasive methods using near-infrared (NIR) light. The low resolution images through the skull with traditional NIR-I (700–1000 nm) were improved by the use of NI…
View article: Optimal focus evaluated using Monte Carlo simulation in non-invasive neuroimaging in the second near-infrared window
Optimal focus evaluated using Monte Carlo simulation in non-invasive neuroimaging in the second near-infrared window Open
Adjusting the focal plane through the intact scalp of mice is crucial in novel angiography of cerebral vasculature using quantum dots emitting second near-infrared light at a wavelength of 1100 nm. Reagents were administered through the ca…
View article: Corrigendum: Bioluminescence Resonance Energy Transfer (BRET)‐coupled Annexin V‐functionalized Quantum Dots for Near‐Infrared Optical Detection of Apoptotic Cells
Corrigendum: Bioluminescence Resonance Energy Transfer (BRET)‐coupled Annexin V‐functionalized Quantum Dots for Near‐Infrared Optical Detection of Apoptotic Cells Open
In the caption of Figure6and the section on BRET luminescence imagingi nt he Supporting Information, the exposure time was incorrectly given as 5minutes.The correct value is 10 minutes.The authors apologize for this error.
View article: A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging
A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging Open
View article: Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging Open
Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.
View article: Critical Review—Water-Soluble Near-Infrared Fluorophores Emitting over 1000 nm and Their Application to In Vivo Imaging in the Second Optical Window (1000–1400 nm)
Critical Review—Water-Soluble Near-Infrared Fluorophores Emitting over 1000 nm and Their Application to In Vivo Imaging in the Second Optical Window (1000–1400 nm) Open
Near-infrared (NIR) emitting fluorophores are widely used as bio-imaging probes for non-invasive visualization of deep-tissues at the whole body level, because of the high permeability and low absorption of NIR light in living tissues. Rec…
View article: In Vivo Imaging of Septic Encephalopathy
In Vivo Imaging of Septic Encephalopathy Open
Septic encephalopathy is a devastating symptom of severe sepsis. Many studies have been performed to uncover the pathophysiological mechanisms of septic encephalopathy; however, novel technical approaches are still required to overcome thi…
View article: Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells
Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells Open
View article: Investigation of pH-dependent photophysical properties of quantum nanocrystals by fluorescence correlation spectroscopy
Investigation of pH-dependent photophysical properties of quantum nanocrystals by fluorescence correlation spectroscopy Open
Quantum dot (QD) and quantum rod (QR) nanocrystals are widely used non-organic nanocrystals. Their strong fluorescence and photostability make them suitable for biomedical imaging applications. However, their pH-dependence and antibunching…
View article: Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain
Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain Open
Near-infrared (NIR) fluorescent imaging is a powerful tool for the non-invasive visualization of the inner structure of living organisms. Recently, NIR fluorescence imaging at 1000–1400 nm (second optical window) has been shown to offer be…
View article: Rotational diffusion measurements using polarization-dependent fluorescence correlation spectroscopy based on superconducting nanowire single-photon detector
Rotational diffusion measurements using polarization-dependent fluorescence correlation spectroscopy based on superconducting nanowire single-photon detector Open
Conventional polarization-dependent fluorescence correlation spectroscopy (pol-FCS) requires two sets of photon detectors to eliminate after-pulse noises (dual-channel pol-FCS; DC-pol-FCS) in the sub-microsecond range. In this study, we su…
View article: Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs
Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs Open
View article: Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging
Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging Open
Significance The application of luminescence imaging has been limited mainly by the two drawbacks of luciferases: low brightness and poor color variants. Here, we report the development of cyan and orange luminescent proteins approximately…
View article: Imaging: Compact Halo‐Ligand‐Conjugated Quantum Dots for Multicolored Single‐Molecule Imaging of Overcrowding GPCR Proteins on Cell Membranes (Small 12/2015)
Imaging: Compact Halo‐Ligand‐Conjugated Quantum Dots for Multicolored Single‐Molecule Imaging of Overcrowding GPCR Proteins on Cell Membranes (Small 12/2015) Open
In single-molecule fluorescence imaging, the optical resolution is restricted by the diffraction limit of light wavelength, which is approximately 200 nm when using visible light emission. M. Ueda, T. Jin, and co-workers show on page 1396 …
View article: Non-Invasive Near-Infrared Fluorescence Imaging in the Second Optical Window
Non-Invasive Near-Infrared Fluorescence Imaging in the Second Optical Window Open
We describe non-invasive near-infrared fluorescence imaging of deep tissues in the wavelength of 1000-1400 nm, which is called as the second optical window. Compared with the first optical window (700-1000 nm), this optical window makes it…