Takashi Kaito
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View article: Efficacy and Safety of Mirogabalin as an Add-on to Nonsteroidal Anti-inflammatory Drugs for Neuropathic Pain Caused by Lumbar Disc Herniation: A Randomized Controlled Study (Miro-Hers)
Efficacy and Safety of Mirogabalin as an Add-on to Nonsteroidal Anti-inflammatory Drugs for Neuropathic Pain Caused by Lumbar Disc Herniation: A Randomized Controlled Study (Miro-Hers) Open
Japan Registry of Clinical Trials (jRCTs061220102, registered 27/February/2023, https://jrct.mhlw.go.jp/en-latest-detail/jRCTs061220102 ).
View article: Effective management of pregnancy- and lactation-associated osteoporosis using romosozumab: a clinical case report
Effective management of pregnancy- and lactation-associated osteoporosis using romosozumab: a clinical case report Open
Pregnancy- and lactation-related osteoporosis (PLO) is a rare condition characterized by reduced bone density and increased fracture risk during late pregnancy or early postpartum. Because of its rarity, no well-established treatment exist…
View article: The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study
The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study Open
The usefulness of spine stabilization for treating metastatic spinal tumors with tumor-induced instability has been reported. However, no reports have prospectively evaluated the effectiveness of adding posterior decompression to stabiliza…
View article: L5 Pedicle Fracture Following Single-Level L4-5 Posterior Lumbar Interbody Fusion: Successful Outcomes With Conservative Treatment in Two Cases
L5 Pedicle Fracture Following Single-Level L4-5 Posterior Lumbar Interbody Fusion: Successful Outcomes With Conservative Treatment in Two Cases Open
View article: Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study
Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study Open
Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. …
View article: Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan
Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan Open
Study Design: A retrospective cohort study.Purpose: This study aimed to compare the efficacy and safety of topical and relatively high-dose intravenous tranexamic acid (TXA) in minimizing postoperative blood loss in patients undergoing sin…
View article: Characteristics and Clinical Outcomes of Transition from Conservative Therapy to Surgical Intervention in Older Patients with Cervical Spinal Cord Injury without Major Bone Injury: A Nationwide Retrospective Study
Characteristics and Clinical Outcomes of Transition from Conservative Therapy to Surgical Intervention in Older Patients with Cervical Spinal Cord Injury without Major Bone Injury: A Nationwide Retrospective Study Open
A significant proportion of older patients with CSCI without major bone injury who were initially managed conservatively eventually required surgery due to insufficient neurological improvement. The outcomes of patients who transitioned to…
View article: Artificial intelligence in spine research: A multimodal perspective beyond imaging
Artificial intelligence in spine research: A multimodal perspective beyond imaging Open
Recent advances in artificial intelligence (AI) have brought significant progress to the field of spine research. While image-based AI applications such as automated spine segmentation and pathology detection have garnered substantial atte…
View article: Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone Open
View article: Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting
Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting Open
Aims Nonunion occurs when a fracture fails to heal permanently, often necessitating surgical intervention to stimulate the bone healing response. Current animal models of long-bone nonunion do not adequately replicate human pathological co…
View article: Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone Open
Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack o…
View article: Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study
Clinical and Economic Outcomes of Intradiscal Injection of Condoliase for a Treatment of Lumbar Disc Herniation with Severe Low Back Pain: A Multicenter Study Open
This retrospective multicenter study revealed that patients with LDH with severe LBP frequently experienced improvement in radicular pain and LBP, which is similar to LDH cases without severe LBP.
View article: "Koshimagari Exercise" for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study
"Koshimagari Exercise" for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study Open
The "Koshimagari Exercise" program led to significant short-term improvements in health-related quality of life and pain among elderly patients with ASD. This home-based self-exercise program is an excellent nonsurgical treatment option fo…
View article: Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion
Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion Open
View article: Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study
Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study Open
Study Design Retrospective study. Objectives To investigate the impact of diabetes mellitus on neurological recovery and determine the relationship between moderate-severe diabetes and neurological recovery in patients with cervical spinal…
View article: Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient’s Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study
Effects of Palliative Surgical Treatment for Spinal Metastases on the Patient’s Quality of Life With a Focus on the Segment of the Metastasis: A Prospective Multicenter Study Open
Study Design Prospective multicenter study. Objectives Palliative surgery is crucial for maintaining the quality of life (QOL) in patients with spinal metastases. This study aimed to compare the short-term outcomes of QOL after palliative …
View article: rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model
rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model Open
Background Nonunion following fracture treatment remains a significant clinical challenge, adversely affecting the patient’s quality of life and imposing a substantial economic burden. The emergence of bone morphogenetic protein 2 (BMP-2) …
View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the Article Cellular senescence by loss of Men1 in osteoblasts is critical for age‐related osteoporosis by Yuichiro Ukon et al., https://doi.org/10.1111/acel.14254 [Image: see text]
View article: Apolipoprotein E is a novel marker for chondrocytes in the growth plate resting zone
Apolipoprotein E is a novel marker for chondrocytes in the growth plate resting zone Open
View article: 64. Comparison of the effects of topical and intravenous administration of tranexamic acid on postoperative blood loss in single-level posterior lumbar interbody fusion
64. Comparison of the effects of topical and intravenous administration of tranexamic acid on postoperative blood loss in single-level posterior lumbar interbody fusion Open
View article: Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosis
Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosis Open
Recent evidence suggests an association between age‐related osteoporosis and cellular senescence in the bone; however, the specific bone cells that play a critical role in age‐related osteoporosis and the mechanism remain unknown. Results …
View article: Appropriate pelvic obliquity measurement method in Lenke type 5C adolescent idiopathic scoliosis: a preliminary study
Appropriate pelvic obliquity measurement method in Lenke type 5C adolescent idiopathic scoliosis: a preliminary study Open
Given the asymmetric sacral morphology, SO is more appropriate pelvic parameter than IO to represent the sacral tilt of Lenke 5C AIS, especially when measured using CT images to overcome the poor visibility on PA whole-spine radiographs.
View article: Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis? A Multicenter Survey
Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis? A Multicenter Survey Open
This study revealed that ankylosis was significantly associated with increased blood loss volume when unadjusted by surgical time. Elderly patients with cervical spine injury accompanied by ankylosis appear predisposed to higher bleeding a…
View article: Identification of unapproved orthopedic regenerative medicine: Usefulness of the Act on Safety of Regenerative Medicine
Identification of unapproved orthopedic regenerative medicine: Usefulness of the Act on Safety of Regenerative Medicine Open
View article: Comparative Analysis of Characteristics of Lower- and Mid-Cervical Spine Injuries in the Elderly
Comparative Analysis of Characteristics of Lower- and Mid-Cervical Spine Injuries in the Elderly Open
Elderly patients with lower-cervical fractures/dislocations were injured by high-energy trauma significantly more often than patients with mid-cervical injuries. Furthermore, half of the patients with lower-cervical injuries had mid-cervic…
View article: Issue Information
Issue Information Open
View article: Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients
Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients Open
Low GNRI before injury was one of the independent risk factors for dysphagia after geriatric cervical SCI. GNRI represents the comprehensive nutritional status of the elderly and reflects feeding function and its recovery capacity.
View article: Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury
Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury Open
This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated con…
View article: Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan
Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan Open
Study Design Retrospective multicenter study. Objectives The effectiveness of early surgery for cervical spinal injury (CSI) has been demonstrated. However, whether early surgery improves outcomes in the elderly remains unclear. This study…
View article: Development of patient-reported outcome for adult spinal deformity: validation study
Development of patient-reported outcome for adult spinal deformity: validation study Open
Adult spinal deformity (ASD) is a complex condition that combines scoliosis, kyphosis, pain, and postoperative range of motion limitation. The lack of a scale that can successfully capture this complex condition is a clinical challenge. We…