Explanipedia

Synaptic bundle theory for spike-driven sensor-motor system: More than eight independent synaptic bundles collapse reward-STDP learning Open

Takeshi Kobayashi, Shogo Yonekura, Yasuo Kuniyoshi · 2025

Neuronal spikes directly drive muscles and endow animals with agile movements, but applying the spike-based control signals to actuators in artificial sensor-motor systems inevitably causes a collapse of learning. We developed a system tha…

Secondary musculoskeletal disability and rehabilitation aspects in adults with thalidomide embryopathy: A narrative review Open

Nobuhiko Haga, Junko Fujitani, Takeshi Kobayashi, Sayaka Fujiwara, Hiroji Tsujimura , et al. · 2025

To review musculoskeletal disabilities and rehabilitation in adults with thalidomide embryopathy (TE), the authors reviewed the literature related to musculoskeletal disability, quality of life (QOL) and rehabilitation intervention in adul…

Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation Open

Yasutaka Sadaga, Daisuke Watanabe, Yuho Najima, Daichi Sadato, Chizuko Hirama , et al. · 2025

We report three cases of ponatinib/blinatumomab (Pona/BLIN) combination therapy as a bridge to allogeneic hematopoietic cell transplantation (allo-HCT) in patients with relapsed/refractory Philadelphia chromosome-positive acute lymphoblast…

IMPROVING CELLULAR THERAPY OPERATIONS THROUGH PRE-HARVEST MEASUREMENT OF PERIPHERAL CD34-POSITIVE CELL COUNTS IN ALLOGENEIC STEM CELL HARVEST Open

Shuhei Kurosawa, Kyoko Haraguchi, Yunoka Honma, Fuyuko Kawai, Moemi Ishiwada , et al. · 2025

Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse Open

Kishio Furuya, Hiroaki Hirata, Takeshi Kobayashi, Hiroshi Ishiguro, Masahiro Sokabe · 2025

The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. However, the source of ATP release has not been elucidated. We measured ATP release during hyp…

Improving cellular therapy operations through pre‐harvest measurement of peripheral CD34‐positive cell counts in allogeneic stem cell harvest Open

Shuhei Kurosawa, Kyoko Haraguchi, Yunoka Honma, Fuyuko Kawai, Moemi Ishiwada , et al. · 2024

Introduction Previously, our institution measured peripheral blood CD34 cell counts both pre‐ and post‐peripheral blood stem cell harvest (PBSCH), with both samples analyzed simultaneously post‐PBSCH. Since 2021, we have measured pre‐CD34 …

Issue Information Open

Shiu‐Kum Lam, Hong Kong, Kunio Okuda, Chiba Lawrie, William A. Powell , et al. · 2024

No abstract is available for this article.

National BioResource Project (NBRP), Human Pathogenic Viruses Open

Takaaki Kinoshita, Keita MATSUNO, Takeshi Kobayashi, Akihisa Kato, Yasushi Kawaguchi , et al. · 2024

Safety of Inguinal Hernia Repair with Antithrombotic Therapy—An Inguinal Incision Approach— Open

Kameda Yasuko, Satoru NAGATANI, Hiroaki Tsumura, Takeshi Kobayashi, Shinya Takahashi , et al. · 2024

Cover Image Open

Atsushi Higashitani, Mika Teranishi, Yui Nakagawa, Yukou Itoh, Surabhi Sudevan , et al. · 2023

The cover image is based on the Research Article Increased mitochondrial Ca2+ contributes to health decline with age and Duchene muscular dystrophy in C. elegans by Atsushi Higashitani et al., https://doi.org/10.1096/fj.202201489RR.

Mechanochemical synthesis of alane Open

Shalabh Gupta, V. K. Pecharsky, Takeshi Kobayashi, Marek Pruski, Ihor Z. Hlova · 2023

In some examples, a method of forming alane (AlH3), the method comprising reacting one of: 1) a MAlH4, wherein M is an alkali metal; 2) alkali-metal hydride, MH; or 3) alkali-metal with one or more aluminum halides (AlX3, where X is a halo…

Increased mitochondrial Ca2+ contributes to health decline with age and Duchene muscular dystrophy in C. elegans Open

Atsushi Higashitani, Mika Teranishi, Yui Nakagawa, Yukou Itoh, Surabhi Sudevan , et al. · 2022

Summary Sarcopenia is a geriatric syndrome characterized by an age-related decline in skeletal muscle mass and strength. Here, we show that suppression of mitochondrial calcium uniporter (MCU)-mediated Ca 2+ influx into mitochondria in the…

Microneedle Array-Assisted, Direct Delivery of Genome-Editing Proteins Into Plant Tissue Open

Anchu Viswan, Ayana Yamagishi, Masamichi Hoshi, Yuichi Furuhata, Yoshio Kato , et al. · 2022

Genome editing in plants employing recombinant DNA often results in the incorporation of foreign DNA into the host genome. The direct delivery of genome-editing proteins into plant tissues is desired to prevent undesirable genetic alterati…

Transcranial Magnetic Stimulation for Neuropathic Pain with Motor Weakness Caused by Spine Orthodontic Fixation Open

Kota Nakamura, Shuntaro Kawaguchi, Takeshi Kobayashi, Tomohito Sato, Yutaro Asakura , et al. · 2022

An 81-year-old woman sustained a fracture of the vertebra, resulting in grace deformation. After surgery for the spinal fixation, she suffered from left femoral neuropathic pain and motor weakness of both lower extremities. Daily repetitiv…

Development of an Oncolytic Mammalian Orthoreovirus Expressing the Near-Infrared Fluorescent Protein Irfp720 Open

Katsuhiro Ogawa, Kentaro Yamada, Tsuyoshi Etoh, Masahiro Kitagawa, Yoshinori Shirasaka , et al. · 2022

Hypo-osmotic Stress Induces ATP Release via Volume-regulated Anion Channels in Undifferentiated Mammary Cells Open

Kishio Furuya, Yuko Takahashi, Hiroaki Hirata, Takeshi Kobayashi, Samsonov MIu , et al. · 2021

The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. However, the source of ATP release has not been elucidated. We measured the ATP release during…

Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes Open

Anayt Ulla, Takayuki Uchida, Yukari Miki, Kosuke Sugiura, Atsushi Higashitani , et al. · 2021

Ultra-high-purity iron is a novel and very compatible biomaterial Open

Luqman Khan, Katsumi Sato, Shinichi Okuyama, Takeshi Kobayashi, Kazumasa Ohashi , et al. · 2020

Metals and alloys are used widely in bone prosthetic materials, stents and dental tissue reconstructions. The most common materials are stainless steels and cobalt-chromium-nickel and titanium alloys. These alloys can be easily deformed bu…

A Case of an Infected Liver Cyst following Cholecystectomy with Drainage for Gallbladder Perforation and Panperitonitis Open

Kenta Baba, Takeshi Kobayashi, Takumi Harada, Keisuke Okano, Takeshi MUTOH , et al. · 2019

症例は88歳，女性．腹痛を主訴に当院を受診し，汎発性腹膜炎による敗血症性ショックの診断で緊急手術を施行した．術中所見で胆嚢穿孔と診断し，胆嚢摘出術および腹腔ドレナージ術を施行した．術前のCTで肝右葉肝門部に認めていた嚢胞が術後徐々に増大し，末梢胆管の拡張を伴っていたが，症状なく経過観察していた．術後61日目に突然の悪寒戦慄を伴う発熱が出現した．CTで胆管炎および感染性肝嚢胞と診断し，同日超音波誘導下に経皮経肝膿瘍ドレナージ術を施行した．白色膿性排液35mlを吸引し，血液培養…

Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells Open

Takayuki Uchida, Yoshihiro Sakashita, Kanako Kitahata, Yui Yamashita, Chisato Tomida , et al. · 2018

Unloading-mediated muscle atrophy is associated with increased reactive oxygen species (ROS) production. We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume (…

P506 Incidence risk of colorectal cancer, non-melanoma skin cancers and non-Hodgkin lymphoma in Japanese patients with ulcerative colitis based on large-scale claims database Open

Takeshi Kobayashi, Akihito Uda, T Mineyama, Eri Udagawa, K Iwasaki , et al. · 2018

Background: Patients with ulcerative colitis (UC) have been reported about not only a higher incidence of colorectal cancer (CRC) compared with general population, but also increased risks of non-melanoma skin cancers (NMSC) and non-Hodgki…

Predictive implications of albumin and C-reactive protein for progression to pneumonia and poor prognosis in Stenotrophomonas maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation Open

Kaito Harada, Noritaka Sekiya, Tatsuya Konishi, Akihito Nagata, Yuta Yamada , et al. · 2017

Allo-HSCT recipients had higher rates of S. maltophilia bacteremia than did patients not receiving allo-HSCT. High serum CRP and low serum albumin at the onset of bacteremia are predictive of disease progression to pneumonia and poor progn…

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells Open

Keiko Maeda, Atsushi Enomoto, Akitoshi Hara, Naoya Asai, Takeshi Kobayashi , et al. · 2016

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited…

Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells Open

Daisuke Matsumoto, Ramachandra Rao Sathuluri, Yoshio Kato, Yaron Silberberg, Ryuzo Kawamura , et al. · 2015

Delivery of biomolecules with use of nanostructures has been previously reported. However, both efficient and high-throughput intracellular delivery has proved difficult to achieve. Here, we report a novel material and device for the deliv…

ISOLATION AND CHARACTERIZATION OF A NOVEL HYALURONIDASE INHIBITOR FROM A MARINE ACTINOMYCETES STRAIN Open

Enjuro Harunari, Chiaki Imada, Yasuhiro Igarashi, Takao Fukuda, Takeshi Terahara , et al. · 2015

A novel hyaluronidase inhibitor (HI) was isolated from the culture extract of a marine- derived actinomycete strain. This strain MB-PO13 was isolated from ascidian (Molgula manhattensis) in Tokyo Bay. Out of about 1,000 isolates from vario…

Development of Electric Characteristics in Rat Heart Open

Noritsugu Tohse, Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Tatsuya Sato · 2015

心筋細胞の電気生理学的特性は,発生期の心臓の形態学的な変化に伴って大きく変容する.発生初期のラット胚では,大部分の細胞で自動能が認められる.膜電位ではペースメーカー電位が確認でき,活動電位全体の形状は,成体の洞房結節細胞のそれと同様である.その後,作業心筋の静止膜電位は過分極し,ペースメーカー電位は失われ,自動能は刺激伝導系の細胞に限定される.この過分極は,内向き整流性K+チャネルが増加してゆくことによって引き起こされる.さらに,活動電位持続時間は誕生後に伴い急速に短縮する…

Additional file 1: Figure S1. of Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis Open

Takeshi Kobayashi, Kensuke Tanaka, Tetsuo Fujita, Hiroki Umezawa, Hiroyuki Amano , et al. · 2015

Blockade of IL-6 at early inflammatory stage of BLM-injured lung affects SMA induction in the lung. Mice were intratracheally administered with IL-6-neutralizing antibody or isotype control at 6, 30 and 54 h (0, 1 and 2 dpi) after instilla…

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