Takashi Tsuji
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View article: Depositional Ages, Sequence Stratigraphy and Transition Process of Forearc Setting From Paleogene Restricted Bay/Estuarine to Neogene Open‐Marine Deltaic/Slope Systems in the Sanriku‐Oki Forearc Basin, Northeast Japan
Depositional Ages, Sequence Stratigraphy and Transition Process of Forearc Setting From Paleogene Restricted Bay/Estuarine to Neogene Open‐Marine Deltaic/Slope Systems in the Sanriku‐Oki Forearc Basin, Northeast Japan Open
This paper aims to discuss the transition process of the forearc basin setting along the Northeast Japan arc, based on the results of strontium isotope dating, resistivity image facies analysis, sequence stratigraphic and depositional syst…
View article: A clinical study of ten-year prognosis in patients with lumbar disc herniation treated with condoliase in a phase III trial
A clinical study of ten-year prognosis in patients with lumbar disc herniation treated with condoliase in a phase III trial Open
No significant imaging findings necessitating surgery were observed, suggesting that chemonucleolysis with condoliase remains a safe and effective treatment option for LDH over the long term.
View article: Multiguest-Induced Structural Switching in a Self-Assembled Monolayer Network at the Liquid–Solid Interface
Multiguest-Induced Structural Switching in a Self-Assembled Monolayer Network at the Liquid–Solid Interface Open
sponsorship: This work was supported by JSPS KAKENHI Grant Number JP20H02553 (for K.T.) and JP15H02164 (for Y.T.), and the National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the…
View article: Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation Open
Mutations in RAS and PI3Kα are major drivers of human cancer. Their interaction plays a crucial role in activating PI3Kα and amplifying the PI3K-AKT-mTOR pathway. Disrupting RAS-PI3Kα interaction enhances survival in lung and skin cancer m…
View article: Effects of Preoperative Cervical Range of Motion on Clinical Outcomes Following Posterior Decompression: A Multicenter Study of Patients With Cervical Ossification of the Posterior Longitudinal Ligament
Effects of Preoperative Cervical Range of Motion on Clinical Outcomes Following Posterior Decompression: A Multicenter Study of Patients With Cervical Ossification of the Posterior Longitudinal Ligament Open
Study Design Retrospective multicenter study. Objectives To investigate the impact of preoperative cervical range of motion (ROM) on clinical outcomes after posterior decompression for cervical ossification of the posterior longitudinal li…
View article: Design of Al<sub>2</sub>O<sub>3</sub>/LaAlO<sub>3</sub>/SiO<sub>2</sub> Gate Stack on Various Channel Planes for High-Performance 4H-SiC Trench Power MOSFETs
Design of Al<sub>2</sub>O<sub>3</sub>/LaAlO<sub>3</sub>/SiO<sub>2</sub> Gate Stack on Various Channel Planes for High-Performance 4H-SiC Trench Power MOSFETs Open
An Al 2 O 3 /LaAlO 3 /SiO 2 gate stack is designed and implemented on various trench-gate channel planes for high-performance trench power MOSFETs. The designed high-k gate stack achieves a significant enhancement in the gate blocking capa…
View article: Genetic insights into ossification of the posterior longitudinal ligament of the spine
Genetic insights into ossification of the posterior longitudinal ligament of the spine Open
Ossification of the posterior longitudinal ligament of the spine (OPLL) is an intractable disease leading to severe neurological deficits. Its etiology and pathogenesis are primarily unknown. The relationship between OPLL and comorbidities…
View article: Author response: Genetic insights into ossification of the posterior longitudinal ligament of the spine
Author response: Genetic insights into ossification of the posterior longitudinal ligament of the spine Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Data availability References Decision letter Author response Article and author information Me…
View article: Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage Open
Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
View article: Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage Open
Purpose: B7 family molecules expressed on antigen-presenting cells stimulate or inhibit normal immune responses. The aim of this study was to investigate whether functional B7.2 and B7-H2 molecules are expressed on myeloma cells and, if so…
View article: Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage Open
Supplementary Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
View article: Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage
Data from Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage Open
Purpose: B7 family molecules expressed on antigen-presenting cells stimulate or inhibit normal immune responses. The aim of this study was to investigate whether functional B7.2 and B7-H2 molecules are expressed on myeloma cells and, if so…
View article: Changes in source rock and reservoir properties of biosiliceous mudstone due to the migration of biogenic silica during burial diagenesis
Changes in source rock and reservoir properties of biosiliceous mudstone due to the migration of biogenic silica during burial diagenesis Open
Diatomaceous deposits are mixtures of diatom tests(biogenic silica)and argillaceous materials. Biogenic silica migrates in the deposits as its mineral phase transforms during burial diagenesis, concentrating and diluting organic matter and…
View article: Genetic insights into ossification of the posterior longitudinal ligament of the spine
Genetic insights into ossification of the posterior longitudinal ligament of the spine Open
Background Ossification of the posterior longitudinal ligament of the spine (OPLL) is an intractable disease, leading to severe neurological deficits. Its etiology and pathogenesis are mostly unknown. The relationship between OPLL and como…
View article: Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of lumbar spinal stenosis, 2021 - Secondary publication
Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of lumbar spinal stenosis, 2021 - Secondary publication Open
The 2021 clinical practice guideline for the management of LSS was completed according to the latest evidence-based medicine. We expect that this guideline will be useful for all medical providers as an index in daily medical care, as well…
View article: Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures Open
Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic eval…
View article: Optimization of NAMPT (Nicotinamide Phosphoribosyltransferase) Activators: Discovery of N,N-Diethyl-1,2-benzoxazole-3-carboxamide Derivatives as Potent NAMPT Activators with Mitigated Mutagenic Risks
Optimization of NAMPT (Nicotinamide Phosphoribosyltransferase) Activators: Discovery of N,N-Diethyl-1,2-benzoxazole-3-carboxamide Derivatives as Potent NAMPT Activators with Mitigated Mutagenic Risks Open
DS68702229, a potent NAMPT activator developed from HTS followed by a hit-to-lead campaign, is a promising candidate compound that significantly reduced body weight when orally administered to mice with high fat diet-induced obesity.Howeve…
View article: Formulation of Japanese Orthopaedic Association (JOA) clinical practice guideline for the management of low back pain- the revised 2019 edition
Formulation of Japanese Orthopaedic Association (JOA) clinical practice guideline for the management of low back pain- the revised 2019 edition Open
The 2019 clinical practice guideline for the management of low back pain was completed according to the latest evidence-based medicine. We strongly hope that this guideline serves as a benchmark for all physicians, as well as patients, in …
View article: Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator Open
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the nicotinamide adenine dinucleotide (NAD+) salvage pathway. Because NAD+ plays a pivotal role in energy metabolism and boosting NAD+ has positive effects …
View article: Changes in Cross-sectional Areas of Posterior Extensor Muscles in Thoracic Spine: A 10-year Longitudinal MRI Study
Changes in Cross-sectional Areas of Posterior Extensor Muscles in Thoracic Spine: A 10-year Longitudinal MRI Study Open
This study aimed to examine changes in the cross-sectional areas (CSAs) of posterior extensor muscles in the thoracic spine over 10 years and identify related factors. The subjects of this study were 85 volunteers (mean age: 44.8 ± 11.5) a…
View article: Tight oil exploration in the Onnagawa formation, Miocene biosiliceous rocks of Japan: what we have learned and its implication for Monterey-like siliceous rocks in the Circum-North Pacific
Tight oil exploration in the Onnagawa formation, Miocene biosiliceous rocks of Japan: what we have learned and its implication for Monterey-like siliceous rocks in the Circum-North Pacific Open
We re-discovered tight/shale oil accumulations through a successful acid treatment in the Onnagawa Formation, the main petroleum source rock in Japan, which is Monterey-like biosiliceous shale of the Middle Miocene age. Its productivity is…
View article: History of exploration and research of Miocene biosiliceous mudstone reservoirs, preliminary study of the reservoir properties in the thermally-matured biosiliceous mudstones of the Onnagawa Formation
History of exploration and research of Miocene biosiliceous mudstone reservoirs, preliminary study of the reservoir properties in the thermally-matured biosiliceous mudstones of the Onnagawa Formation Open
Exploration and development of biosiliceous mudstone has been carried out in California, USA, Sakhalin, Russia, and Japan. Although the exploration scale of biosiliceous mudstone differs between Japan and California, both exploration activ…
View article: Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis
Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis Open
Metabolic syndrome was significantly associated with DISH. Our data showed metabolic syndrome is potentially related to DISH.
View article: Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model
Quantitative analysis of intervertebral disc degeneration using Q‐space imaging in a rat model Open
The degree of intervertebral disc (IVD) degeneration is qualitatively evaluated on T2‐weighted imaging (T2WI). However, it is difficult to assess subtle changes in IVD degeneration using T2WI. Q‐space imaging (QSI) is a quantitative diffus…
View article: Stereospecific Epitaxial Growth of Bilayered Porous Molecular Networks
Stereospecific Epitaxial Growth of Bilayered Porous Molecular Networks Open
Stereocontrolled multilayer growth of supramolecular porous networks at the interface between graphite and a solution was investigated. For this study, we designed a chiral dehydrobenzo[12]annulene (DBA) building block bearing alkoxy chain…