Takashi Ueda
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View article: ABCG transporters are involved in the accumulation of specialized metabolites in the oil bodies of <i>Marchantia polymorpha</i>
ABCG transporters are involved in the accumulation of specialized metabolites in the oil bodies of <i>Marchantia polymorpha</i> Open
Bioactive specialized metabolites (SMs) are synthesized and sequestered in specific cellular compartments or organelles as a self-defense strategy against their intrinsic toxicity. Liverwort-specific oil bodies accumulate large amounts of …
View article: Amyloplasts are necessary for full gravitropism in thallus of <i>Marchantia polymorpha</i>
Amyloplasts are necessary for full gravitropism in thallus of <i>Marchantia polymorpha</i> Open
Gravitropism is a plant response to gravity that directs organ growth and development, playing a key role in the adaptation of land plants. While its molecular basis has been extensively studied in flowering plants, much less is known abou…
View article: Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development
Comparative Proteomic Profiling of Receptor Kinase Signaling Reveals Key Trafficking Components Enforcing Plant Stomatal Development Open
Receptor kinases are pivotal for growth, development, and environmental response of plants. Yet, their regulatory mechanisms and spatial dynamics are still underexplored. The ERECTA-family receptor kinases coordinate diverse developmental …
View article: Effect of Body Mass Index in Patients With Cardiogenic Shock Requiring Microaxial Flow Pump
Effect of Body Mass Index in Patients With Cardiogenic Shock Requiring Microaxial Flow Pump Open
Higher BMI was associated with increased mortality in CS patients treated with mAFP. Although patients who were underweight demonstrated overall favorable survival outcomes, bleeding and hemolysis contributed to mortality in this group. Fu…
View article: REAP1/AtSWAP70 Integrates RAB5 and ROP Signaling During Sexual Reproduction
REAP1/AtSWAP70 Integrates RAB5 and ROP Signaling During Sexual Reproduction Open
Small GTPases of the Ras superfamily are critical regulators of diverse cellular processes. While cross-talk between their signaling pathways has been documented in animals, similar mechanisms remain unexplored in plants, where small GTPas…
View article: Management of a Mass Casualty Incident Involving Foreign Workers: Insights From a Single-Center Response to a Microbus Accident in Japan
Management of a Mass Casualty Incident Involving Foreign Workers: Insights From a Single-Center Response to a Microbus Accident in Japan Open
This case study emphasizes the significance of three critical components for the effective management of multicultural MCIs. First, dynamic triage protocols must be designed to accommodate language barriers, ensuring equitable and timely c…
View article: Genetic Analysis of<i>Arabidopsis</i>Autophagy-Related 8 Family Proteins Reveals Their Redundant and Regulatory Roles in Plant Autophagy
Genetic Analysis of<i>Arabidopsis</i>Autophagy-Related 8 Family Proteins Reveals Their Redundant and Regulatory Roles in Plant Autophagy Open
Autophagy, a critical process for the vacuolar degradation of proteins and organelles, is governed by multiple conserved autophagy-related (ATG) proteins. The central component of the ATG machinery is the ubiquitin-like protein ATG8, which…
View article: Establishment of Gemma Dormancy in Marchantia polymorpha via Coordinated Regulation of Phytohormonal and Cell Cycle Pathways by MpHYPNOS
Establishment of Gemma Dormancy in Marchantia polymorpha via Coordinated Regulation of Phytohormonal and Cell Cycle Pathways by MpHYPNOS Open
View article: A Pilot Study Using a Smartwatch to Search for Biomarkers of Heart Rate Variability in Active Ulcerative Colitis
A Pilot Study Using a Smartwatch to Search for Biomarkers of Heart Rate Variability in Active Ulcerative Colitis Open
Introduction: Autonomic imbalance has been reported to correlate with clinical remission in patients with ulcerative colitis (UC). This study evaluated heart rate variability (HRV), a potential digital biomarker, in patients with active UC…
View article: Contrasting Pathogenic Mechanisms in Acute and Subacute Gallbladder Volvulus: Analysis of Two Cases with Different Degrees of Torsion
Contrasting Pathogenic Mechanisms in Acute and Subacute Gallbladder Volvulus: Analysis of Two Cases with Different Degrees of Torsion Open
View article: Amyloplasts are necessary for full gravitropism in thallus of<i>Marchantia polymorpha</i>
Amyloplasts are necessary for full gravitropism in thallus of<i>Marchantia polymorpha</i> Open
Gravitropism is a response in which plants sense gravity and determine the direction of organ growth and development. This trait is important for adaptation in land plants. The molecular mechanisms of gravitropism have been studied mainly …
View article: Retrieval from vacuolar/endosomal compartments underpinning neofunctionalization of SNARE in plants
Retrieval from vacuolar/endosomal compartments underpinning neofunctionalization of SNARE in plants Open
The distinctive protein and lipid composition underlies the distinct function of each organelle, regulated by balanced anterograde and retrograde membrane trafficking. The vacuole, the largest plant organelle, is pivotal in various plant f…
View article: TYPHON proteins are RAB-dependent mediators of the <i>trans</i>-Golgi network secretory pathway
TYPHON proteins are RAB-dependent mediators of the <i>trans</i>-Golgi network secretory pathway Open
The trans-Golgi network (TGN), a key compartment in endomembrane trafficking, participates in both secretion to and endocytosis from the plasma membrane. Consequently, the TGN plays a key role in plant growth and development. Understanding…
View article: Characterization of Subcellular Dynamics of Sterol Methyltransferases Clarifies Defective Cell Division in smt2 smt3, a C-24 Ethyl Sterol-Deficient Mutant of Arabidopsis
Characterization of Subcellular Dynamics of Sterol Methyltransferases Clarifies Defective Cell Division in smt2 smt3, a C-24 Ethyl Sterol-Deficient Mutant of Arabidopsis Open
An Arabidopsis sterol mutant, smt2 smt3, defective in sterolmethyltransferase2 (SMT2), exhibits severe growth abnormalities. The loss of C-24 ethyl sterols, maintaining the biosynthesis of C-24 methyl sterols and brassinosteroids, suggests…
View article: Ectopic Adrenocorticotropic Hormone Syndrome due to Pancreatic Neuroendocrine Carcinoma
Ectopic Adrenocorticotropic Hormone Syndrome due to Pancreatic Neuroendocrine Carcinoma Open
A 55-year-old woman presented to her primary care physician with facial and lower leg edema. After being referred to our hospital because of hypothyroidism and hypokalemia on blood tests, she also had elevated adrenocorticotropic hormone (…
View article: Publisher Correction: A non-canonical BZR/BES transcription factor regulates the development of haploid reproductive organs in Marchantia polymorpha
Publisher Correction: A non-canonical BZR/BES transcription factor regulates the development of haploid reproductive organs in Marchantia polymorpha Open
View article: Impella 5.5 Placement Across Evolut FX Transcatheter Aortic Valve: Balloon-Assisted Procedure
Impella 5.5 Placement Across Evolut FX Transcatheter Aortic Valve: Balloon-Assisted Procedure Open
View article: Significance of Epidemiological Background in Preventing the Misdiagnosis of Intestinal Tuberculosis as Crohn's Disease
Significance of Epidemiological Background in Preventing the Misdiagnosis of Intestinal Tuberculosis as Crohn's Disease Open
The misdiagnosis of intestinal tuberculosis (ITB), such as Crohn's disease (CD), and subsequent treatment with immunosuppressive therapies can lead to severe outcomes. However, the differential diagnosis between these two conditions can be…
View article: Gaining New Insights in Plant Biology through Human–Machine Collaboration
Gaining New Insights in Plant Biology through Human–Machine Collaboration Open
View article: Harnessing Deep Learning to Analyze Cryptic Morphological Variability of <i>Marchantia polymorpha</i>
Harnessing Deep Learning to Analyze Cryptic Morphological Variability of <i>Marchantia polymorpha</i> Open
Characterizing phenotypes is a fundamental aspect of biological sciences, although it can be challenging due to various factors. For instance, the liverwort Marchantia polymorpha is a model system for plant biology and exhibits morphologic…
View article: The SYP123–VAMP727 SNARE complex delivers secondary cell wall components for root hair shank hardening in Arabidopsis
The SYP123–VAMP727 SNARE complex delivers secondary cell wall components for root hair shank hardening in Arabidopsis Open
The extended tubular shape of root hairs is established by tip growth and concomitant hardening. Here, we demonstrate that a syntaxin of plants (SYP)123–vesicle-associated membrane protein (VAMP)727-dependent secretion system delivers seco…
View article: LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants
LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants Open
View article: Harnessing Deep Learning to Analyze Cryptic Morphological Variability of<i>Marchantia polymorpha</i>
Harnessing Deep Learning to Analyze Cryptic Morphological Variability of<i>Marchantia polymorpha</i> Open
Characterizing phenotypes is a fundamental aspect of biological sciences, although it can be challenging due to various factors. For instance, the liverwort ( Marchantia polymorpha ), a model system for plant biology, exhibits morphologica…
View article: Targeting of <scp>SIRPα</scp> as a potential therapy for Langerhans cell histiocytosis
Targeting of <span>SIRPα</span> as a potential therapy for Langerhans cell histiocytosis Open
Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a + CD207 + dendritic cells (DCs). SIRPα is a transmembrane protein highly exp…
View article: Autophagy regulates plastid reorganization during spermatogenesis in the liverwort Marchantia polymorpha
Autophagy regulates plastid reorganization during spermatogenesis in the liverwort Marchantia polymorpha Open
Autophagy is a highly conserved system that delivers cytoplasmic components to lysosomes/vacuoles. Plastids are also degraded through autophagy for nutrient recycling and quality control; however, the involvement of autophagic degradation …
View article: Transcatheter Aortic Valve Implantation via Subclavian Approach Ipsilateral to Shunt Arm：Case Series
Transcatheter Aortic Valve Implantation via Subclavian Approach Ipsilateral to Shunt Arm：Case Series Open
大動脈弁狭窄症に対する経カテーテル的大動脈弁植込術(TAVI)を透析用シャント肢と同側の鎖骨下動脈アプローチを用いて行った4例を報告する.症例は70~79歳,左上肢に透析用シャントが作成されていた.いずれも大動脈弁置換術は髙リスク(STSスコア6.292~12.624)と考えられ,TAVIを行うこととなった.腸骨動脈の狭窄・石灰化もしくは総大腿動脈の高度石灰化のため,左鎖骨下動脈アプローチを選択した.術前大動脈弁圧較差は30.2~44.2mmHgであったが,術後3.0~5.…
View article: Genetic and phosphoproteomic basis of LysM-mediated immune signaling in<i>Marchantia polymorpha</i>highlights conserved elements and new aspect of pattern-triggered immunity in land plants
Genetic and phosphoproteomic basis of LysM-mediated immune signaling in<i>Marchantia polymorpha</i>highlights conserved elements and new aspect of pattern-triggered immunity in land plants Open
Pattern-recognition receptor (PRR)-triggered immunity (PTI) wards off a wide range of pathogenic microbes, playing a pivotal role in plant immunity. The model liverwort Marchantia polymorpha is emerging as a popular model for investigating…
View article: A case of breast cancer with extensive colon metastasis
A case of breast cancer with extensive colon metastasis Open
Breast cancer is one of the most common malignancies in women worldwide. Although most breast cancers are curable, in cases of metastasis, many are often found in the lungs, bones, liver, and central nervous system; however, metastasis to …
View article: Special Issue: “10th Anniversary of JCM—Recent Diagnostic and Therapeutic Advances in Gastroenterology and Hepatopancreatobiliary Medicine”
Special Issue: “10th Anniversary of JCM—Recent Diagnostic and Therapeutic Advances in Gastroenterology and Hepatopancreatobiliary Medicine” Open
This Special Issue, “10th Anniversary of JCM—Recent Diagnostic and Therapeutic Advances in Gastroenterology and Hepatopancreatobiliary Medicine”, presents five original articles and two review articles [...]
View article: The renaissance and enlightenment of<i>Marchantia</i>as a model system
The renaissance and enlightenment of<i>Marchantia</i>as a model system Open
The liverwort Marchantia polymorpha has been utilized as a model for biological studies since the 18th century. In the past few decades, there has been a Renaissance in its utilization in genomic and genetic approaches to investigating phy…