Takashi Uno
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View article: Does PSA Nadir + 2 ng/mL Always Indicate Biochemical Recurrence? A PSA Kinetics-Based Evaluation Following Carbon Ion Radiotherapy for Localized High-Risk Prostate Cancer
Does PSA Nadir + 2 ng/mL Always Indicate Biochemical Recurrence? A PSA Kinetics-Based Evaluation Following Carbon Ion Radiotherapy for Localized High-Risk Prostate Cancer Open
Background: Biochemical recurrence after radiotherapy for prostate cancer is commonly defined by the Phoenix criteria (prostate-specific antigen [PSA] nadir + 2 ng/mL). However, some patients experience PSA elevation without clinical recur…
View article: New workflow and motion analysis for gastric mucosa-associated lymphoid tissue lymphoma on a 1.5-T MR-Linac
New workflow and motion analysis for gastric mucosa-associated lymphoid tissue lymphoma on a 1.5-T MR-Linac Open
We developed and evaluated a multiplane cine magnetic resonance imaging (MRI) workflow for magnetic resonance (MR)-guided online adaptive radiation therapy (MRgOART) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Two patien…
View article: Comprehensive registry of esophageal cancer in Japan, 2016
Comprehensive registry of esophageal cancer in Japan, 2016 Open
Background The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the characteristics, treatments, and outcomes of patients who underwent any treatment in 2016 in Japan. Methods We analyzed dat…
View article: A Case of IgG4-Related Disease Presenting With Concurrent Uveitis, Posterior Scleritis, Serous Retinal Detachment, and Choroidal Thickening Mimicking Intraocular Lymphoma
A Case of IgG4-Related Disease Presenting With Concurrent Uveitis, Posterior Scleritis, Serous Retinal Detachment, and Choroidal Thickening Mimicking Intraocular Lymphoma Open
IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition characterized by tumor-like lesions, dense lymphoplasmacytic infiltrates rich in IgG4-positive plasma cells, and often elevated serum IgG4 levels. Ocular involvement…
View article: Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease
Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease Open
Rigidity, a cardinal symptom of Parkinson's disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This s…
View article: Impact of bulk density assignment of bone on MRI‐based abdominal region radiotherapy planning for MR‐linac workflow
Impact of bulk density assignment of bone on MRI‐based abdominal region radiotherapy planning for MR‐linac workflow Open
Purpose The purpose of the present study was to evaluate the impact of bone relative electron density (rED) assignment on radiotherapy planning for the abdominal region. Methods Twenty patients who received abdominal radiotherapy using MR‐…
View article: Cross sectional dopamine transporter imaging and myocardial sympathetic scintigraphy study in patients with dementia with Lewy bodies
Cross sectional dopamine transporter imaging and myocardial sympathetic scintigraphy study in patients with dementia with Lewy bodies Open
Background Dopamine transporter ( 123 I‐FP‐CIT) single‐photon emission tomography (SPECT) and 123 I‐meta‐iodobenzylguanidine ( 123 I‐MIBG) image play roles as indicative biomarkers in diagnosing patients with dementia with Lewy bodies (DLB…
View article: Feasibility of creating a daily adaptive plan using automatic DIR-created target and OARs contours in patients with prostate cancer magnetic-resonance-guided adaptive radiotherapy
Feasibility of creating a daily adaptive plan using automatic DIR-created target and OARs contours in patients with prostate cancer magnetic-resonance-guided adaptive radiotherapy Open
The purpose of this study was to evaluate the feasibility of treatment plans for prostate cancer with magnetic resonance (MR)-guided online adaptive radiotherapy, which are generated using deformable image registration (DIR)-created contou…
View article: Comparative Efficacy and Safety of the β3-Adrenoceptor Agonist Vibegron for Urgency and Mixed Urinary Incontinence: A Post Hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled Phase 3 Study
Comparative Efficacy and Safety of the β3-Adrenoceptor Agonist Vibegron for Urgency and Mixed Urinary Incontinence: A Post Hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled Phase 3 Study Open
Objective To compare the efficacy of vibegron for urgency urinary incontinence (UUI) and mixed urinary incontinence (MUI) in patients with overactive bladder (OAB). Methods We performed a post hoc analysis of a phase 3 study of vibegron in…
View article: Two-fractionated stereotactic magnetic resonance-guided adaptive radiation therapy for patients with prostate cancer (SMART PRO trial): protocol for a confirmatory clinical trial
Two-fractionated stereotactic magnetic resonance-guided adaptive radiation therapy for patients with prostate cancer (SMART PRO trial): protocol for a confirmatory clinical trial Open
Introduction In an MRI-guided linear accelerator (MR-LINAC) system, the planned doses for organs at risk and for tumours are assessed by MR imaging and re-contouring at every treatment. This allows treatment to be safer and more precise by…
View article: Feasibility and Safety of the Distal Transradial Access for Noncardiac Intervention
Feasibility and Safety of the Distal Transradial Access for Noncardiac Intervention Open
Results revealed that distal transradial access is feasible with commercially available catheters and is safe for various noncardiac interventions.
View article: Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open
The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little i…
View article: Impact of the COVID-19 Pandemic on Hypofractionated Radiation Therapy Use for Breast Cancer in Japan: A Nationwide Study
Impact of the COVID-19 Pandemic on Hypofractionated Radiation Therapy Use for Breast Cancer in Japan: A Nationwide Study Open
Although conventional RT for breast cancer has been gradually replaced by hypofractionated RT, it remains predominant. The use of hypofractionated RT increased briefly early in the COVID-19 pandemic; however, this increase was not sustaine…
View article: Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies
Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies Open
Background: Dementia with Lewy bodies (DLB) presents with various symptoms, posing challenges for early diagnosis challenging. Dopamine transporter (123I-FP-CIT) single-photon emission tomography (SPECT) and 123I-meta-iodobenzylguanidine (…
View article: A pilot study on interobserver variability in organ-at-risk contours in magnetic resonance imaging-guided online adaptive radiotherapy for pancreatic cancer
A pilot study on interobserver variability in organ-at-risk contours in magnetic resonance imaging-guided online adaptive radiotherapy for pancreatic cancer Open
Purpose Differences in the contours created during magnetic resonance imaging-guided online adaptive radiotherapy (MRgOART) affect dose distribution. This study evaluated the interobserver error in delineating the organs at risk (OARs) in …
View article: A Novel Evaluation for Vertebral Artery Course Using 3D Magnetic Resonance Imaging with Computed Tomography -like Bone Contrast and Magnetic Resonance Angiography: A Proof of Concept Study
A Novel Evaluation for Vertebral Artery Course Using 3D Magnetic Resonance Imaging with Computed Tomography -like Bone Contrast and Magnetic Resonance Angiography: A Proof of Concept Study Open
The integration of the FRACTURE sequence and TOF MRA presents a promising methodology for the precise evaluation of VA courses in the cervical spine. This approach improves preoperative planning for cervical spine surgery with detailed ana…
View article: Phase I/II study of stereotactic body radiotherapy boost in patients with cervical cancer ineligible for intracavitary brachytherapy
Phase I/II study of stereotactic body radiotherapy boost in patients with cervical cancer ineligible for intracavitary brachytherapy Open
View article: Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics
Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics Open
Background L-type amino acid transporter 1 (LAT1) is overexpressed in various cancers; therefore, radiohalogen-labeled amino acid derivatives targeting LAT1 have emerged as promising candidates for cancer radiotheranostics. However, 211 At…
View article: Neurosarcoidosis with enlargement of the dorsal root ganglia: A case report
Neurosarcoidosis with enlargement of the dorsal root ganglia: A case report Open
View article: Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open
The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little i…
View article: The impact of the <scp>COVID</scp>‐19 pandemic on radiotherapy delivery in Japan: An observational study based on the national database
The impact of the <span>COVID</span>‐19 pandemic on radiotherapy delivery in Japan: An observational study based on the national database Open
Background This study analyzed the impact of the coronavirus disease 2019 (COVID‐19) pandemic on radiotherapy delivery in Japan using a high‐quality Japanese national database based on universal health coverage. Methods We performed a retr…
View article: Applying artificial intelligence using routine clinical data for preoperative diagnosis and prognosis evaluation of gastric cancer
Applying artificial intelligence using routine clinical data for preoperative diagnosis and prognosis evaluation of gastric cancer Open
The present study employed artificial intelligence (AI) machine learning technology to evaluate the prognosis of gastric cancer using blood collection data, commonly used in clinical practice and subsequently performed a stratification dis…
View article: Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer
Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer Open
Surgery is the standard treatment for stage I non-small cell lung cancer (NSCLC); however, no clear randomized trial demonstrates its superiority to stereotactic body radiotherapy (SBRT) regarding survival. We aimed to retrospectively eval…
View article: Evaluation of the MVCT-based radiomic features as prognostic factor in patients with head and neck squamous cell carcinoma
Evaluation of the MVCT-based radiomic features as prognostic factor in patients with head and neck squamous cell carcinoma Open
Background Megavoltage computed tomography (MVCT) images acquired during each radiotherapy session may be useful for delta radiomics. However, no studies have examined whether the MVCT-based radiomics has prognostic power. Therefore, the p…
View article: Long-Term Follow-up of a Randomized Controlled Trial on Accelerated Radiation Therapy Versus Standard Fractionated Radiation Therapy for Early Glottic Cancer (JCOG0701A3)
Long-Term Follow-up of a Randomized Controlled Trial on Accelerated Radiation Therapy Versus Standard Fractionated Radiation Therapy for Early Glottic Cancer (JCOG0701A3) Open
After long-term follow-up, Ax showed comparable efficacy to SF and a tendency for better safety. Ax may be suitable for early glottic cancer because of its convenience in minimizing treatment time, cost, and labor.
View article: A new workflow of the on-line 1.5-T MR-guided adaptive radiation therapy
A new workflow of the on-line 1.5-T MR-guided adaptive radiation therapy Open
View article: Delivery accuracy of VMAT on two beam‐matched linacs provided by accelerated go live service
Delivery accuracy of VMAT on two beam‐matched linacs provided by accelerated go live service Open
Introduction Dosimetric accuracy is critical when a patient treated with volumetric modulated arc therapy (VMAT) is transferred to another beam‐matched linac. To evaluate the performance of Accelerated Go Live (AGL) service, the measured b…
View article: Improvement of Image Quality in Low-Count Bone Scintigraphy Using Deep Learning
Improvement of Image Quality in Low-Count Bone Scintigraphy Using Deep Learning Open
Objective To improve image quality for low-count bone scintigraphy whole-body images using deep learning and evaluate their applicability in clinical practice. Methods Five hundred fifty patients were included in the study. Low-count Origi…
View article: Prognosis prediction of uterine cervical cancer using changes in the histogram and texture features of apparent diffusion coefficient during definitive chemoradiotherapy
Prognosis prediction of uterine cervical cancer using changes in the histogram and texture features of apparent diffusion coefficient during definitive chemoradiotherapy Open
Objectives We investigated prospectively whether, in cervical cancer (CC) treated with concurrent chemoradiotherapy (CCRT), the Apparent diffusion coefficient (ADC) histogram and texture parameters and their change rates during treatment c…
View article: Prophylactic Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Embolization of Renal Angiomyolipoma: A Comparative Study
Prophylactic Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Embolization of Renal Angiomyolipoma: A Comparative Study Open
The prophylactic use of steroids before and after embolization of renal AML may be effective in preventing PES in this small retrospective study.