Takashi Yoshioka
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View article: Clinical Implications of Coexisting EWSR1 Rearrangements in Ewing Sarcoma: A Database Analysis and Representative Cases
Clinical Implications of Coexisting EWSR1 Rearrangements in Ewing Sarcoma: A Database Analysis and Representative Cases Open
Background Ewing sarcoma (ES) is a highly aggressive malignancy with a poor prognosis, particularly in metastatic disease. While localized disease treated with multimodal therapy achieves favorable survival rates, metastatic disease at pre…
View article: Validating the Nepalese Short Attitudes Toward Mental Health Problems Scale (N-SATMHPS): A Culturally Sensitive Tool for Assessing Mental Health Stigma
Validating the Nepalese Short Attitudes Toward Mental Health Problems Scale (N-SATMHPS): A Culturally Sensitive Tool for Assessing Mental Health Stigma Open
(1) Background: Negative attitudes toward mental health problems (ATMHP) remain a barrier to help-seeking, especially in collectivist, lower-middle-income countries like Nepal. While the Attitudes Towards Mental Health Problems Scale (ATMH…
View article: Ureteroscopic Lithotripsy for A Surgical Clip‐Induced Renal Stone Following Laparoscopic Partial Nephrectomy
Ureteroscopic Lithotripsy for A Surgical Clip‐Induced Renal Stone Following Laparoscopic Partial Nephrectomy Open
Introduction Surgical clips used in laparoscopic and robot‐assisted surgeries can occasionally migrate into the upper urinary tract, serving as nidi for stone formation. We report a case of a surgical clip‐induced renal stone successfully …
View article: Reporting Quality in Health Economic Evaluation Studies of Immune Checkpoint Inhibitors: A Systematic Review
Reporting Quality in Health Economic Evaluation Studies of Immune Checkpoint Inhibitors: A Systematic Review Open
View article: Association of gambling activities and modalities with problem gambling in Japan: A nationwide cross-sectional online survey-based study
Association of gambling activities and modalities with problem gambling in Japan: A nationwide cross-sectional online survey-based study Open
Experiences in online sports betting, online and offline casinos, and cryptocurrency trading demonstrated statistically significant associations with the prevalence of PG. These findings emphasize the need for legal awareness of casinos an…
View article: Pancreatic Mixed Acinar-neuroendocrine Carcinoma in a Patient With a Germline<i>PTEN</i>Variant: A Case Report and Genomic Literature Review
Pancreatic Mixed Acinar-neuroendocrine Carcinoma in a Patient With a Germline<i>PTEN</i>Variant: A Case Report and Genomic Literature Review Open
This case highlights a rare presentation of pancreatic cancer in CS/PHTS with distinct molecular and histological features. The absence of KRAS mutation and presence of germline PTEN variant may have contributed to the aggres…
View article: Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database
Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database Open
Epidermal growth factor receptor (EGFR) inhibition is crucial in treating RAS wild-type metastatic colorectal cancer, yet current testing methods may miss rare RAS variants affecting treatment efficacy. We analyzed 4122 colorectal cancer p…
View article: Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database
Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database Open
Background: Epidermal growth factor receptor (EGFR) inhibition is crucial in treating RAS wild-type metastatic colorectal cancer, yet current testing methods may miss rare RAS variants affecting treatment efficacy. Methods/Results: We anal…
View article: Health utility value of overactive bladder in Japanese older adults
Health utility value of overactive bladder in Japanese older adults Open
Objectives To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged ≥65 ye…
View article: The estimation of healthcare cost of kidney transplantation in Japan using large-scale administrative databases
The estimation of healthcare cost of kidney transplantation in Japan using large-scale administrative databases Open
View article: Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021
Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021 Open
This longitudinal study revealed a gradual downward trend in the number of hospitals and hospital beds owned by medical corporations, while horizontal and vertical integration gradually progressed without any particular medical corporation…
View article: Health Utility Value of Overactive Bladder in Japanese Older Adults
Health Utility Value of Overactive Bladder in Japanese Older Adults Open
Objectives To determine the health utility values (HUVs) of overactive bladder (OAB) among adults aged ≥65 years and to assess the HUV decrements (disutilities) of OAB according to its severity. Methods This cross-sectional Internet-based …
View article: Quality-of-life survey of pancreatic cancer patients: a comparison between general public and physicians
Quality-of-life survey of pancreatic cancer patients: a comparison between general public and physicians Open
Background Quality-of-life (QOL) is important for cancer patients with poor prognosis. However, conducting a QOL survey with patients is difficult. Therefore, we conducted a QOL survey with physicians. Specifically, this study aimed to cla…
View article: Estimation of Sexual and Gender Minorities in the adult population of Japan: Descriptive Epidemiological Study utilizing a Nationwide Cross-Sectional Internet Survey
Estimation of Sexual and Gender Minorities in the adult population of Japan: Descriptive Epidemiological Study utilizing a Nationwide Cross-Sectional Internet Survey Open
Background Descriptive study of Japanese sexual and gender minority (SGM) population with national representativeness have not been conducted. We sought to estimate the proportion of the Japanese SGM, and to describe those demographic, soc…
View article: Association of night-shift work with gambling and problem gambling among workers in Japan: A nationwide cross-sectional study
Association of night-shift work with gambling and problem gambling among workers in Japan: A nationwide cross-sectional study Open
Night-shift work was associated with gambling among workers and with problem gambling among those who gambled.
View article: Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021
Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021 Open
Background Medical corporations, which aim to operate hospitals, clinics, or long-term care facilities, account for more than half of all hospital beds and play a central role in the health care system in Japan. However, limited analysis o…
View article: Comment on “Predicting the risk stratification of gastrointestinal stromal tumors using machine learning-based ultrasound radiomics”
Comment on “Predicting the risk stratification of gastrointestinal stromal tumors using machine learning-based ultrasound radiomics” Open
View article: Reporting Quality in Health Economic Evaluation Studies of Immune Checkpoint Inhibitors: A Systematic Review
Reporting Quality in Health Economic Evaluation Studies of Immune Checkpoint Inhibitors: A Systematic Review Open
Objectives This study assessed the reporting quality of health economic evaluation (HEE) studies of immune checkpoint inhibitors (ICIs). Methods We conducted a systematic literature search of four databases (PubMed, EMBASE, Cochrane CENTRA…
View article: Cost-Effectiveness Analysis of Nivolumab Plus Ipilimumab Combination Therapy as First-line Treatment for Advanced Renal Cell Carcinoma in Japan
Cost-Effectiveness Analysis of Nivolumab Plus Ipilimumab Combination Therapy as First-line Treatment for Advanced Renal Cell Carcinoma in Japan Open
View article: Toward the prevention of group B streptococcal early onset sepsis: the importance of defining target populations and second-line antimicrobials in line with current guideline recommendations
Toward the prevention of group B streptococcal early onset sepsis: the importance of defining target populations and second-line antimicrobials in line with current guideline recommendations Open
View article: Consideration of Defining the Detailed Target Population and Mortality Rates: Key Factors in Achieving Generalizable Results
Consideration of Defining the Detailed Target Population and Mortality Rates: Key Factors in Achieving Generalizable Results Open
View article: Protocol digest of a randomized controlled Phase III study comparing surgery alone versus adjuvant nivolumab versus adjuvant S-1 for locally advanced oesophageal squamous cell carcinoma with no pathological complete response after neoadjuvant chemotherapy followed by curative esophagectomy: Japan Clinical Oncology Group study JCOG2206 (SUNRISE Trial)
Protocol digest of a randomized controlled Phase III study comparing surgery alone versus adjuvant nivolumab versus adjuvant S-1 for locally advanced oesophageal squamous cell carcinoma with no pathological complete response after neoadjuvant chemotherapy followed by curative esophagectomy: Japan Clinical Oncology Group study JCOG2206 (SUNRISE Trial) Open
Although the efficacy of postoperative therapy with nivolumab after preoperative chemoradiotherapy for locally advanced oesophageal cancer has been proven in Western countries, the survival benefits of postoperative therapy after preoperat…
View article: Bladder training for treating overactive bladder in adults
Bladder training for treating overactive bladder in adults Open
This review focused on the effect of bladder training to treat OAB. However, most of the evidence was low or very-low certainty. Based on the low- or very low-certainty evidence, bladder training may cure or improve OAB compared to no trea…
View article: Global Trends in Highly Cited Studies in COVID-19 Research
Global Trends in Highly Cited Studies in COVID-19 Research Open
Importance Since the onset of the COVID-19 outbreak, an extremely high number of studies have been published worldwide, with variable quality. Research trends of highly cited papers may enable identification of influential research, provid…
View article: Social Isolation/Loneliness and Tooth Loss in Community-Dwelling Older Adults: The Sukagawa Study
Social Isolation/Loneliness and Tooth Loss in Community-Dwelling Older Adults: The Sukagawa Study Open
Background and Objectives The relationship between social isolation/loneliness and oral health is unclear. This study investigated the association between social isolation/loneliness and tooth loss in older Japanese adults. Research Design…
View article: High-toughness/resistivity ruthenium-based refractory alloy wires
High-toughness/resistivity ruthenium-based refractory alloy wires Open
View article: Quality-Of-Life Survey of Pancreatic Cancer Patients: A Comparison Between General Public and Physicians
Quality-Of-Life Survey of Pancreatic Cancer Patients: A Comparison Between General Public and Physicians Open
Quality-of-life (QOL) is important for cancer patients with poor prognosis. However, QOL survey is difficult using patients. We created cancer scenarios and investigated QOL utility values among the general public using vignette-based meth…
View article: Longitudinal Association of Working From Home on Work Functioning Impairment in Desk Workers During COVID-19 Pandemic
Longitudinal Association of Working From Home on Work Functioning Impairment in Desk Workers During COVID-19 Pandemic Open
Objective This study clarifies the longitudinal association between working from home and work functioning impairment among desk workers. Methods Nationwide surveys were conducted from 2020 to 2022, analyzing 3532 desk workers who never wo…
View article: Phase II study of biweekly cetuximab plus mFOLFOX6 or mFOLFIRI as second-line treatment for metastatic colorectal cancer and exploratory analysis of associations between DNA methylation status and the efficacy of the anti-EGFR antibody: T-CORE1201
Phase II study of biweekly cetuximab plus mFOLFOX6 or mFOLFIRI as second-line treatment for metastatic colorectal cancer and exploratory analysis of associations between DNA methylation status and the efficacy of the anti-EGFR antibody: T-CORE1201 Open
Biweekly cetuximab plus mFOLFOX6 or mFOLFIRI is a useful second-line therapy for mCRC. DNA methylation status warrants further exploration as a predictive biomarker for anti-EGFR efficacy in mCRC.
View article: Comment on: A higher frequency of physical activity is associated with reduced rates of SARS-CoV-2 infection
Comment on: A higher frequency of physical activity is associated with reduced rates of SARS-CoV-2 infection Open
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