Takatoshi Kasai
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View article: Obstructive sleep apnea and arterial stiffness: is heart rate a mediator?
Obstructive sleep apnea and arterial stiffness: is heart rate a mediator? Open
View article: Prognostic impact of the acute reactiveness to intravenous administration of tolvaptan sodium phosphate in patients with acute decompensated heart failure
Prognostic impact of the acute reactiveness to intravenous administration of tolvaptan sodium phosphate in patients with acute decompensated heart failure Open
Aims Intravenous tolvaptan sodium phosphate (IV-tolvaptan) is a novel aquaretic agent for acute decompensated heart failure (ADHF). This study evaluated its short-term effects and prognostic implications in clinical practice. Methods and r…
View article: Efficacy of Adaptive Servo-Ventilation in Worsening Heart Failure
Efficacy of Adaptive Servo-Ventilation in Worsening Heart Failure Open
Despite advancements in heart failure (HF) therapies, managing symptoms and congestion remains challenging for some patients. Adaptive servo-ventilation (ASV) has been used in Japan to treat residual congestion in chronic HF, but its effic…
View article: Validation of Automated Respiratory Event Scoring in Type 3 Home Sleep Apnea Testing
Validation of Automated Respiratory Event Scoring in Type 3 Home Sleep Apnea Testing Open
Automatic scoring of REI using this polygraphy device showed good correlation and agreement with manual scoring. The favorable correlation and agreement were more pronounced with the Somnolyzer system.
View article: Relationship between heart rate variability and cancer management
Relationship between heart rate variability and cancer management Open
In patients with advanced cancer, the prevalence rate of cardiac autonomic neuropathy (CAN) is high, and the prognosis of patients with CAN is generally poor. Although mechanisms including inflammation, infection, metabolism, neurodegenera…
View article: Sarcopenia in heart failure: Comparison of prognostic value between the Asian working Group for Sarcopenia 2014 and 2019 criteria
Sarcopenia in heart failure: Comparison of prognostic value between the Asian working Group for Sarcopenia 2014 and 2019 criteria Open
Aim Sarcopenia is a prevalent comorbidity among older patients with heart failure. This study aimed to evaluate the differences between sarcopenia diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2014 and 2019 criteria in olde…
View article: The Impact of Macronutrient Intake on Sleep Quality in Female Endurance Athletes: A Pilot Observational Cross-Sectional Study
The Impact of Macronutrient Intake on Sleep Quality in Female Endurance Athletes: A Pilot Observational Cross-Sectional Study Open
Background/Objectives: Sleep is essential for athletes. However, the impact of dietary habits on sleep quality in female endurance athletes at risk for low energy availability (LEA) is underexplored. This was a pilot study to examine the c…
View article: Effects of Worsening Renal Function and Changes in Blood Urea Nitrogen Level During Hospitalization on Clinical Outcome in Patients with Acute Decompensated Heart Failure
Effects of Worsening Renal Function and Changes in Blood Urea Nitrogen Level During Hospitalization on Clinical Outcome in Patients with Acute Decompensated Heart Failure Open
Background/Objectives: Worsening renal function (WRF) during hospitalization for acute decompensated heart failure (ADHF) is associated with poor clinical outcomes. Data on the impact of WRF on clinical outcomes, considering blood urea nit…
View article: Serum Levels of Exocrine Pancreatic Enzymes in Patients with Acute Decompensated Heart Failure
Serum Levels of Exocrine Pancreatic Enzymes in Patients with Acute Decompensated Heart Failure Open
Background: Interactions between the heart and other organs have been a focus in acute decompensated heart failure (ADHF). However, the association between ADHF and pancreatic exocrine insufficiency (PEI), which may lead to malnutrition, r…
View article: Lifestyle change during the COVID-19 pandemic in Japan: implications for continuous positive airway pressure adherence in obstructive sleep apnea patient
Lifestyle change during the COVID-19 pandemic in Japan: implications for continuous positive airway pressure adherence in obstructive sleep apnea patient Open
The COVID-19 pandemic has resulted in many lifestyle changes. More than 50% of workers who was CPAP user changed their work style, resulting in decreased physical activity, and commuters tended to have shorter durations and lower rates of …
View article: Relationship Between Serum Levels of Pancreatic Exocrine Enzymes on Admission and Long-Term Clinical Outcomes in Patients with Acute Decompensated Heart Failure
Relationship Between Serum Levels of Pancreatic Exocrine Enzymes on Admission and Long-Term Clinical Outcomes in Patients with Acute Decompensated Heart Failure Open
Background/Objectives: Heart failure (HF) can damage organs because of poor perfusion and/or congestion. The interactions between HF and other organs have recently been studied; however, data on the interaction between HF and pancreatic ex…
View article: Editorial: Organ support in cardiac intensive care
Editorial: Organ support in cardiac intensive care Open
View article: Accuracy of Cup Placement Angle, Leg Lengthening, and Offset Measurement Using an AR-Based Portable Navigation System: Validation in Supine and Lateral Decubitus Positions for Total Hip Arthroplasty
Accuracy of Cup Placement Angle, Leg Lengthening, and Offset Measurement Using an AR-Based Portable Navigation System: Validation in Supine and Lateral Decubitus Positions for Total Hip Arthroplasty Open
Background and Objectives: Total hip arthroplasty (THA) requires accurate implant placement to ensure optimal outcomes. In this study, the AR Hip navigation system, an imageless portable navigation tool using augmented reality (AR), was ev…
View article: Effects of CPAP on Atherosclerotic Coronary Plaques in Patients with Sleep-Disordered Breathing
Effects of CPAP on Atherosclerotic Coronary Plaques in Patients with Sleep-Disordered Breathing Open
View article: Overlap of frailty and malnutrition as prognosticators in older patients with heart failure
Overlap of frailty and malnutrition as prognosticators in older patients with heart failure Open
Physical frailty and malnutrition coexist in approximately one-quarter of hospitalized older patients with HF and are associated with an increased risk of mortality. Assessing both conditions is crucial for risk stratification and interven…
View article: The usefulness of an intra-oral tongue stimulation device
The usefulness of an intra-oral tongue stimulation device Open
View article: Effect of Cereal Consumption (Frugra<sup>®</sup>) on Autonomic Nervous System Function in Healthcare Workers Who Skip Breakfast
Effect of Cereal Consumption (Frugra<sup>®</sup>) on Autonomic Nervous System Function in Healthcare Workers Who Skip Breakfast Open
In this study, we aimed to clarify the effects of breakfast intervention on autonomic nerve function in healthcare workers who skip breakfast. This cross-sectional, interventional study was conducted between January 2020 and December 2021.…
View article: Rehospitalisation risk by hypnotics class in older patients with heart failure: a cohort study utilizing administrative claims data in Japan
Rehospitalisation risk by hypnotics class in older patients with heart failure: a cohort study utilizing administrative claims data in Japan Open
Background Studies comparing the safety of orexin receptor antagonists and other hypnotic types for older patients with heart failure (HF) remain lacking. This study aimed to compare orexin receptor antagonists (suvorexant) with benzodiaze…
View article: Lymphocyte‐to‐C‐reactive protein ratio and score in patients with heart failure: Nutritional status, physical function, and prognosis
Lymphocyte‐to‐C‐reactive protein ratio and score in patients with heart failure: Nutritional status, physical function, and prognosis Open
Aims In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. In this study, we aimed to assess how novel nutritional–inflammatory markers and lymphocyte‐to‐C‐reactive protein ratio (LCR) and score (LCS…
View article: The Correlation between the Severity of Obstructive Sleep Apnea and Insulin Resistance in a Japanese Population
The Correlation between the Severity of Obstructive Sleep Apnea and Insulin Resistance in a Japanese Population Open
Background: Repetitive episodes of apnea and hypopnea during sleep in patients with obstructive sleep apnea (OSA) are known to increase the risk of atherosclerosis. Underlying obesity and related disorders, such as insulin resistance, are …
View article: Prognostic Value of Objective Social Isolation and Loneliness in Older Patients With Heart Failure: Subanalysis of FRAGILE‐HF and Kitasato Cohort
Prognostic Value of Objective Social Isolation and Loneliness in Older Patients With Heart Failure: Subanalysis of FRAGILE‐HF and Kitasato Cohort Open
Background Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social factors have attracted considerable research attention, informat…
View article: Feasibility of self-measurement telemonitoring using a handheld heart sound recorder in patients with heart failure – SELPH multicenter pilot study
Feasibility of self-measurement telemonitoring using a handheld heart sound recorder in patients with heart failure – SELPH multicenter pilot study Open
Self-telemonitoring with multiple devices including a handheld heart sound recorder was feasible even in elderly patients with HF. This intervention may confer a sense of relief to patients and enable monitoring of physiological parameters…
View article: Changes in the Objective Measures of Sleep in Association with Menses Among Female Athletes with Poor Subjective Sleep Quality: Female Athletes with Poor Subjective Sleep Quality Have More Sleep Arousals During Menses
Changes in the Objective Measures of Sleep in Association with Menses Among Female Athletes with Poor Subjective Sleep Quality: Female Athletes with Poor Subjective Sleep Quality Have More Sleep Arousals During Menses Open
Collegiate female athletes with regular menstrual cycles are likely to have poor subjective sleep quality in association with more frequent arousal during the first night after the onset of menses than during the mid-follicular phase.
View article: Chronic Effects of Adaptive Servo-Ventilation Therapy on Mortality and the Urgent Rehospitalization Rate in Patients Experiencing Recurrent Admissions for Heart Failure ― A Multicenter Prospective Observational Study (SAVIOR-L) ―
Chronic Effects of Adaptive Servo-Ventilation Therapy on Mortality and the Urgent Rehospitalization Rate in Patients Experiencing Recurrent Admissions for Heart Failure ― A Multicenter Prospective Observational Study (SAVIOR-L) ― Open
Chronic use of ASV did not impact all-cause mortality in patients experiencing recurrent admissions for HF.
View article: Elevated levels of plasma inactive stromal cell derived factor-1α predict poor long-term outcomes in diabetic patients following percutaneous coronary intervention
Elevated levels of plasma inactive stromal cell derived factor-1α predict poor long-term outcomes in diabetic patients following percutaneous coronary intervention Open
Background Since the complication of diabetes mellitus (DM) is a risk for adverse cardiovascular outcomes in patients with coronary artery disease (CAD), appropriate risk estimation is needed in diabetic patients following percutaneous cor…
View article: Changepoint Detection in Heart Rate Variability Indices in Older Patients Without Cancer at End of Life Using Ballistocardiography Signals: Preliminary Retrospective Study
Changepoint Detection in Heart Rate Variability Indices in Older Patients Without Cancer at End of Life Using Ballistocardiography Signals: Preliminary Retrospective Study Open
Background In an aging society such as Japan, where the number of older people continues to increase, providing in-hospital end-of-life care for all deaths, and end-of-life care outside of hospitals, such as at home or in nursing homes, wi…
View article: Prognostic impact of MitraScore in elderly Asian patients with heart failure: sub‐analysis of FRAGILE‐HF
Prognostic impact of MitraScore in elderly Asian patients with heart failure: sub‐analysis of FRAGILE‐HF Open
Aims MitraScore is a novel, simple, and manually calculatable risk score developed as a prognostic model for patients undergoing transcatheter edge‐to‐edge repair (TEER) for mitral regurgitation. As its components are considered prognostic…
View article: Adaptive servo-ventilation for sleep-disordered breathing in patients with heart failure with reduced ejection fraction (ADVENT-HF): a multicentre, multinational, parallel-group, open-label, phase 3 randomised controlled trial
Adaptive servo-ventilation for sleep-disordered breathing in patients with heart failure with reduced ejection fraction (ADVENT-HF): a multicentre, multinational, parallel-group, open-label, phase 3 randomised controlled trial Open
View article: Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea
Cross-Sectional Relationship Between Atrial Conduction Delay and Arterial Stiffness in Patients with Obstructive Sleep Apnea Open
In patients with OSA, an increase in arterial stiffness is associated with atrial conduction delay.
View article: Prognostic impact of a novel risk score for transcatheter edge-to-edge repair in patients with heart failure: sub-analysis of FRAGILE-HF
Prognostic impact of a novel risk score for transcatheter edge-to-edge repair in patients with heart failure: sub-analysis of FRAGILE-HF Open
Background MitraScore is a novel, simple, and manually calculatable risk score developed as a prognostic model for patients undergoing transcatheter edge-to-edge repair (TEER) for mitral regurgitation. As its components are considered prog…