Explanipedia

Current Status and Issues of Hepatitis B Reactivation in Gunma Prefecture Open

Satoru Kakizaki, Hiroki Tojima, Yuichi Yamazaki, Yuhei Suzuki, Takashi Hoshino , et al. · 2025

Association Between Liver Injury and Pneumonia in Patients Hospitalized with COVID-19, -With a Focus on Pregnant Women Open

Tatsuma Murakami, Yuichi Yamazaki, Yumeo Tateyama, Yuki Kanayama, Daisuke Uehara , et al. · 2025

Sodium-Glucose Cotransporter-Specific Substrate αMG Stimulates Endogenous Glucagon Secretion and Ameliorates Obesity-Associated Metabolic Disorders in Mice Open

Takayoshi Suga, Yoko Tabei, Osamu Kikuchi, Daisuke Kohno, Yuichi Ikeuchi , et al. · 2025

Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study Open

Takayoshi Suga, Satoru Kakizaki, Atsushi Naganuma, Takeshi Hatanaka, Satoshi Takakusagi , et al. · 2024

Background Oral thrombopoietin receptor agonists are used to treat thrombocytopenia in patients with chronic liver disease who are scheduled for invasive procedures. The efficacy of lusutrombopag based on the pretreatment platelet count wa…

Hepatocellular carcinoma with gastric adenocarcinoma treated with atezolizumab and bevacizumab Open

Takayoshi Suga, Yuko Kimura, Kensuke Furuya, Hiroko Sato · 2023

Key Clinical Message Atezolizumab and bevacizumab combination therapy might be one of the treatment options for hepatocellular carcinoma concurrent with gastric adenocarcinoma.

Hepatocellular carcinoma with gastric adenocarcinoma treated with atezolizumab and bevacizumab Open

Takayoshi Suga, Yuko Kimura, Kensuke Furuya, Hiroko Sato · 2023

Hepatocellular carcinoma concurent with gastric adenocarcinoma is a rare but possible case. In addition, selecting an effective treatment for two primary cancers is often difficult. In this report, we present the first case of hepatocellul…

Adolescents with chronic hepatitis C might be good candidates for direct‐acting antiviral therapy Open

Ken Sato, Yuichi Yamazaki, Yuki Kanayama, Daisuke Uehara, Hiroki Tojima , et al. · 2022

Three Japanese adolescents with chronic hepatitis C were treated by direct‐acting antivirals (DAAs). No adverse events or laboratory abnormalities were observed during and after DAA therapy, and a sustained virological response was achieve…

The first reported case of Noonan syndrome complicated with hepatocellular carcinoma Open

Satoru Kakizaki, Daisuke Uehara, Hiroki Tojima, Takayoshi Suga, Yuichi Yamazaki , et al. · 2021

Noonan syndrome is a genetic multisystem disorder and is associated with mutation of genes encoding the proteins in the RAS‐MAPK pathway. We reported the first case of Noonan syndrome complicated with hepatocellular carcinoma.

Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice Open

Eri Wada, Masaki Kobayashi, Daisuke Kohno, Osamu Kikuchi, Takayoshi Suga , et al. · 2021

Dysregulation of glucagon is associated with the pathophysiology of type 2 diabetes. We previously reported that postprandial hyperglucagonemia is more obvious than fasting hyperglucagonemia in type 2 diabetes patients. However, which nutr…

Characteristics of liver injury in cases of COVID-19 Open

Yuichi Yamazaki, Daisuke Uehara, Yuki Kanayama, Takayoshi Suga, Hiroki Tojima , et al. · 2021

In novel coronavirus disease 2019 (COVID-19), liver injury was found at a high rate, and reports from outside Japan revealed that such injury was related to severity. We examined the characteristics of liver injury in 15 cases of COVID-19.…

The first reported case of Noonan syndrome complicated with hepatocellular carcinoma. Open

Satoru Kakizaki, Daisuke Uehara, Hiroki Tojima, Takayoshi Suga, Yuichi Yamazaki , et al. · 2021

Noonan syndrome is a genetic multisystem disorder characterized by distinctive facial features, developmental delay, congenital heart disease, and other conditions. It is associated with mutation of genes encoding the proteins in the RAS-M…

Characteristics of cases of hepatitis E in 2019 in Gunma prefecture: a small epidemic caused by the same subgenotype 3a strain Open

Yuichi Yamazaki, Daisuke Uehara, Yuki Kanayama, Takayoshi Suga, Takashi Ueno , et al. · 2020

In 2019, the number of reported cases of hepatitis E in Gunma prefecture was 1.44 per 100,000 people, which was the highest in all of Japan. We examined the clinical characteristics of 20 cases of hepatitis E reported in 2019 and analyzed …

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling Open

Takayoshi Suga, Ken Sato, Tatsuya Ohyama, Sho Matsui, Takeshi Kobayashi , et al. · 2020

Our study suggests that the liver steatosis-ameliorating effects of ipragliflozin in ob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly through the PGC-1α/PPARα-FGF21 pathway.

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling Open

Takayoshi Suga, Ken Sato, Tatsuya Ohyama, Sho Matsui, Takeshi Kobayashi , et al. · 2020

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice Open

Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka , et al. · 2018

SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels Open

Takayoshi Suga, Osamu Kikuchi, Masaki Kobayashi, Sho Matsui, Hiromi Yokota‐Hashimoto , et al. · 2018

A Rare Cause of Esophageal Varices Open

Takayoshi Suga, Hirotaka Arai, Hisashi Takayama · 2016

Probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir Open

Takayoshi Suga · 2015

A 66-year-old, interferon-ineligible, treatment-naive man who was diagnosed with chronic hepatitis C due to hepatitis C virus genotype 1b began combination therapy with daclatasvir and asunaprevir. On day 14 of treatment, hepatic reserve a…

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