Takayuki Honda
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View article: Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases Open
Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly inv…
View article: Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution Open
View article: Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis
Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis Open
View article: Lifetime Risk Assessment of Cancer Based on Radioactivity Analysis of Honey Collected in Japan
Lifetime Risk Assessment of Cancer Based on Radioactivity Analysis of Honey Collected in Japan Open
View article: A strong association between TTF-1 expression and interstitial lung disease in predicting the efficacy of PD-1 inhibitor for nonsquamous NSCLC patients
A strong association between TTF-1 expression and interstitial lung disease in predicting the efficacy of PD-1 inhibitor for nonsquamous NSCLC patients Open
Background Thyroid transcriptional factor-1 (TTF-1) is associated with the development of interstitial lung disease (ILD) and is a mutational target in lung adenocarcinoma with ILD. TTF-1 expression is also associated with the efficacy of …
View article: Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers
Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers Open
Background Lung adenocarcinoma (LUAD) in never-smokers is a major public health burden, especially among East Asian women. Polygenic risk scores (PRSs) are promising for risk stratification but are primarily developed in European-ancestry …
View article: Immunohistochemistry of p53 surrogates TP53 mutation as an accurate predictor for early-relapse of surgically resected stage I-III lung adenocarcinoma
Immunohistochemistry of p53 surrogates TP53 mutation as an accurate predictor for early-relapse of surgically resected stage I-III lung adenocarcinoma Open
TP53 mutation is a potential marker for worse prognosis in surgically resected LADC; immunohistochemistry for p53 could be a surrogate method to identify patients with LADC with a worse prognosis.
View article: Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report
Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report Open
Background The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been noted for their seve…
View article: Effective Treatment of Lung Adenocarcinoma With a Novel SLC44A1-BRAF Fusion Using Pembrolizumab Followed by Trametinib: A Case Report
Effective Treatment of Lung Adenocarcinoma With a Novel SLC44A1-BRAF Fusion Using Pembrolizumab Followed by Trametinib: A Case Report Open
View article: Solitary Pure Ground-glass Opacity Suspected of Being the Initial Presentation of Nonfibrotic Hypersensitivity Pneumonitis
Solitary Pure Ground-glass Opacity Suspected of Being the Initial Presentation of Nonfibrotic Hypersensitivity Pneumonitis Open
We herein report a rare case of hypersensitivity pneumonitis (HP) that was initially demonstrated as solitary pure ground-glass opacity (GGO) on chest computed tomography (CT). A 51-year-old woman with a history of breast cancer underwent …
View article: Implant fixation of primary total hip arthroplasty using a cementless cup for osteoarthritis secondary to developmental dysplasia of the hip: A prospective multicenter study in Japan
Implant fixation of primary total hip arthroplasty using a cementless cup for osteoarthritis secondary to developmental dysplasia of the hip: A prospective multicenter study in Japan Open
Purpose: This prospective multicenter study investigated the implant fixation of a cementless cup in primary total hip arthroplasty (THA) for osteoarthritis (OA) secondary to developmental dysplasia of the hip (DDH) in Japanese patients. M…
View article: Impact of Germline Variants on Breast and Ovarian Cancer Risk in Japanese Women: An Original Cohort Study and Meta-Analysis
Impact of Germline Variants on Breast and Ovarian Cancer Risk in Japanese Women: An Original Cohort Study and Meta-Analysis Open
View article: Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses Open
View article: The possibility of mutations of RAS signaling genes and/or <i>TP53</i> in combination as a negative prognostic impact on pathological stage I non‐small cell lung cancer
The possibility of mutations of RAS signaling genes and/or <i>TP53</i> in combination as a negative prognostic impact on pathological stage I non‐small cell lung cancer Open
Background The recurrence rate of non‐small cell lung cancer (NSCLC) is as high as 30%, even in the cancer with pathological stage I disease. Therefore, identifying factors predictive of high‐risk pathological recurrence is important. Howe…
View article: Pulmonary Artery Aneurysm in a Patient with Nontuberculous Mycobacteria Infection
Pulmonary Artery Aneurysm in a Patient with Nontuberculous Mycobacteria Infection Open
Nontuberculous mycobacterial (NTM) infection sometimes leads to the development of pulmonary artery aneurysm (PAA), a rare but life-threatening complication. We herein report a 64-year-old woman with a history of NTM infection who presente…
View article: High density and proximity of <scp>CD8</scp><sup>+</sup><scp>T</scp> cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma
High density and proximity of <span>CD8</span><sup>+</sup><span>T</span> cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma Open
Background The efficacy of immune checkpoint inhibitors (ICIs) in pleural mesothelioma has recently been established. The response to ICIs can be predicted by quantitative analysis of cells and their spatial distribution in the tumor micro…
View article: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population Open
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East …
View article: Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity Open
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononu…
View article: COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease
COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease Open
Coronavirus disease 2019 (COVID-19) pneumonia is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently accompanied by various sequelae. Interstitial lung diseases (ILDs) are observed in COVID-19 pneumonia…
View article: Evaluating the potential of immunotherapy and chemoimmunotherapy in the treatment of elderly non-small cell lung cancer patients: A real-world study
Evaluating the potential of immunotherapy and chemoimmunotherapy in the treatment of elderly non-small cell lung cancer patients: A real-world study Open
The efficacy and safety of ICI in elderly NSCLC patients were not inferior to those in younger patients.
View article: Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report Open
View article: The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force Open
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dyna…
View article: DOCK2 is involved in the host genetics and biology of severe COVID-19
DOCK2 is involved in the host genetics and biology of severe COVID-19 Open
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during …
View article: Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases
Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases Open
Factors associated with mortality are important in the treatment of coronavirus disease 2019 (COVID-19). Polymerase chain reaction (PCR) is the gold standard for diagnosing COVID-19, which reflects the viral load in the upper respiratory t…
View article: A phase <scp>II</scp> feasibility study of carboplatin and nab‐paclitaxel for advanced non‐small cell lung cancer patients with interstitial lung disease (<scp>YLOG0114</scp>)
A phase <span>II</span> feasibility study of carboplatin and nab‐paclitaxel for advanced non‐small cell lung cancer patients with interstitial lung disease (<span>YLOG0114</span>) Open
Background A standard treatment regimen for advanced non‐small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) has not been established since most clinical trials exclude such patients because of the high risk of acu…
View article: Clinical factors predicting the severity of obstructive sleep apnea in interstitial lung disease
Clinical factors predicting the severity of obstructive sleep apnea in interstitial lung disease Open
Background and Objectives: Obstructive sleep apnea (OSA) is known to be one of the common complications of interstitial lung disease (ILD). Although it is suspected that the incidence of OSA and the progression of ILD are closely related t…
View article: Profile of metastatic lung cancer patients susceptible to development of thromboembolism during immunotherapy
Profile of metastatic lung cancer patients susceptible to development of thromboembolism during immunotherapy Open
The profiles of lung cancer patients susceptible to development of thromboembolism (TE) during immunotherapy are unclear, even though TE is associated with a worse prognosis. Here, association studies of variables relevant to TE revealed t…
View article: Exploratory Factors Relevant to the Success of the Oncomine™ Dx Target Test<sup>®</sup>
Exploratory Factors Relevant to the Success of the Oncomine™ Dx Target Test<sup>®</sup> Open
目的．オンコマイン™ Dx Target TestⓇ（ODxTT）の検査成功率は不安定なため，ODxTT成功に寄与する因子の同定を目的とした．方法．2018年6月～2020年12月に診断した非小細胞肺癌のうちODxTTを用いてBRAF遺伝子変異を解析した51例，マルチプレックス解析した生検検体19例を対象に，臨床病理学的因子と検査成功の関連を検討した．結果．検査成功率は手術検体・外科的生検100%，TBB 75%，EBUS-TBNA 78%，CTGB 57%で，生検検体の核…
View article: P8‐146: Comparison of progression free survival and overall survival between 1st and 2nd generation tyrosine kinase inhibitors as first line therapy for non small cell lung cancer
P8‐146: Comparison of progression free survival and overall survival between 1st and 2nd generation tyrosine kinase inhibitors as first line therapy for non small cell lung cancer Open
Background: Gefitinib, Erlotinib, and Afatinib are Epidermal Growth Factor Receptor -Tyrosine Kinase Inhibitors (EGFR-TKIs) which are effective in increasing progressionfree survival (PFS) and overall survival (OS) in patient with non-smal…
View article: P2‐58: Effects of food nutritional components on lung cancer cell lines
P2‐58: Effects of food nutritional components on lung cancer cell lines Open
Background: Particulate matter (PM) which contains various transition metals, in particular iron which generates hydroxy radicals, can penetrate the distal regions of the lung causing respiratory and cardiovasucular diseases.Aims: The purp…