Takayuki Kishi
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View article: Discovery and development of an oral analgesic targeting the α2B adrenoceptor
Discovery and development of an oral analgesic targeting the α2B adrenoceptor Open
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonists such as clonidine and dexmedetomidine exhibit analgesic and opioid-sparing effects. Howev…
View article: Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels Open
Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events. Because compounds that act on TRP channels are potential candidates for therapeutic…
View article: Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features
Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features Open
Objectives Four-and-a-half LIM domains 1 (FHL1) is a muscle-specific protein. Autoantibodies against FHL1 were recently discovered in adults with idiopathic inflammatory myopathies (IIMs) and were found to be associated with clinical featu…
View article: Anti-SAE autoantibody-positive Japanese patient with juvenile dermatomyositis complicated with interstitial lung disease - a case report
Anti-SAE autoantibody-positive Japanese patient with juvenile dermatomyositis complicated with interstitial lung disease - a case report Open
Background Clinical phenotypes and outcomes in juvenile dermatomyositis (JDM) have been defined by various myositis-specific autoantibodies (MSAs). One of the recently described MSAs associated with DM is targeted against the small ubiquit…
View article: Anti-nuclear matrix protein 2 antibody-positive idiopathic inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash
Anti-nuclear matrix protein 2 antibody-positive idiopathic inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash Open
Objective Myositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to…
View article: S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation Open
View article: Anti-SAE Autoantibody-Positive Japanese Patient with Juvenile Dermatomyositis complicated with Interstitial Lung Disease - A Case Report
Anti-SAE Autoantibody-Positive Japanese Patient with Juvenile Dermatomyositis complicated with Interstitial Lung Disease - A Case Report Open
Background Clinical phenotypes and outcomes in juvenile dermatomyositis (JDM) have been defined by various myositis-specific autoantibodies (MSAs). One of the recently described MSAs associated with DM is targeted against the small ubiquit…
View article: Anti-MDA5 autoantibodies associated with juvenile dermatomyositis constitute a distinct phenotype in North America
Anti-MDA5 autoantibodies associated with juvenile dermatomyositis constitute a distinct phenotype in North America Open
Objective Myositis-specific autoantibodies have defined distinct phenotypes of patients with juvenile myositis (JIIM). We assessed the frequency and clinical significance of anti-melanoma differentiation-associated gene 5 (MDA5) autoantibo…
View article: Corticosteroid discontinuation, complete clinical response and remission in juvenile dermatomyositis
Corticosteroid discontinuation, complete clinical response and remission in juvenile dermatomyositis Open
Objective A North American registry of JDM patients was examined for frequency of and factors associated with corticosteroid discontinuation, complete clinical response and remission. Methods We evaluated probability of achieving final cor…
View article: Synchronized Tactile Stimulation on Upper Limbs Using a Wearable Robot for Gait Assistance in Patients With Parkinson's Disease
Synchronized Tactile Stimulation on Upper Limbs Using a Wearable Robot for Gait Assistance in Patients With Parkinson's Disease Open
This study aimed to investigate whether using a wearable robot applying interactive rhythmic stimulation on the upper limbs of patients with Parkinson's disease (PD) could affect their gait. The wearable robot presented tactile stimuli on …
View article: Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis
Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis Open
Objective. Circulating endothelial cells (CEC), von Willebrand factor (vWF) antigen, P-selectin, and thrombomodulin are released from damaged endothelium, while decreases in circulating endothelial progenitor cells (CEPC) have been associa…
View article: AB1025 HARMONIZING JAPANESE VERSION OF THE CHILDHOOD HEALTH ASSESSMENT QUESTIONNAIRE (CHAQ) WITH CHAQ
AB1025 HARMONIZING JAPANESE VERSION OF THE CHILDHOOD HEALTH ASSESSMENT QUESTIONNAIRE (CHAQ) WITH CHAQ Open
View article: Illuminating G-Protein-Coupling Selectivity of GPCRs
Illuminating G-Protein-Coupling Selectivity of GPCRs Open
Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. …
View article: Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis
Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis Open
View article: Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis
Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis Open
CAJDM may be distinguished from JDM, in that they often have p155/140 (transcriptional intermediary factor 1) autoantibodies, have fewer systemic manifestations and receive less therapy.
View article: Vasodilatory Response to Knee Extension with Different Loads
Vasodilatory Response to Knee Extension with Different Loads Open
Purpose] Changes in vasodilatory response after knee extension with different loads were investigated.[Subjects and Methods] The subjects were 17 healthy men with a mean age of 20.4 years, mean body mass of 63.9 kg, mean height of 172.7 cm…
View article: Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody
Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody Open
A 10-year-old girl manifested persistent fever, skin rash, leg pain, fatigue, and joint pain. Based on muscle weakness, elevated muscle-derived enzymes, magnetic resonance imaging, and skin biopsy results, the diagnosis was juvenile idiopa…
View article: A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias Open
View article: Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS<sub>1</sub>by Docking-Aided Structure–Activity Analysis
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS<sub>1</sub>by Docking-Aided Structure–Activity Analysis Open
The ligands of certain G-protein-coupled receptors (GPCRs) have been identified as endogenous lipids, such as lysophosphatidylserine (LysoPS). Here, we analyzed the molecular basis of the structure-activity relationship of ligands of GPR34…
View article: SAT0376 ANTI-NT5C1A autoantibodies are frequent in juvenile myositis and associated with increased illness severity
SAT0376 ANTI-NT5C1A autoantibodies are frequent in juvenile myositis and associated with increased illness severity Open
View article: Association of Anti–3‐Hydroxy‐3‐Methylglutaryl‐Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients
Association of Anti–3‐Hydroxy‐3‐Methylglutaryl‐Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients Open
Objective Autoantibodies recognizing 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) are associated with statin exposure, the HLA allele DRB1*11:01, and necrotizing muscle biopsies in adult myositis patients. The aim of this study …
View article: A nationwide survey of pediatric acquired demyelinating syndromes in Japan
A nationwide survey of pediatric acquired demyelinating syndromes in Japan Open
Our results clarify the characteristic clinical features of pediatric ADS in the Japanese population.
View article: Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation
Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation Open
Upon various stimulations, mast cells (MCs) release a wide variety of chemical mediators stored in their cytoplasmic granules, which then initiates subsequent allergic reactions. Lysophosphatidylserine (LysoPS), a kind of lysophospholipid,…
View article: Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity
Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity Open
The regulation of cell-substrate adhesion is tightly linked to the malignant phenotype of tumor cells and plays a role in their migration, invasion, and metastasis. Focal adhesions (FAs) are dynamic adhesion structures that anchor the cell…
View article: Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity
Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity Open
Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator that specifically activates membrane proteins of the P2Y and its related families of G protein-coupled receptors (GPCR), GPR34 (LPS1), P2Y10 (LPS2), and GPR174 (LPS3). Here, i…
View article: Childhood‐Onset Anti‐Ku Antibody‐Positive Generalized Morphea with Polymyositis: A Japanese Case Study
Childhood‐Onset Anti‐Ku Antibody‐Positive Generalized Morphea with Polymyositis: A Japanese Case Study Open
We report a 16‐year‐old Japanese girl with anti‐Ku antibody‐positive generalized morphea and polymyositis who, at the age of 7 years, developed multiple brownish plaques on her left forearm that gradually extended to her upper arm, back, a…
View article: Structure–Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174
Structure–Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174 Open
Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human…
View article: EP-1437: Comparison of dose-volume parameters between the AIP and the Ex-phase CT imaging for lung SBRT planning
EP-1437: Comparison of dose-volume parameters between the AIP and the Ex-phase CT imaging for lung SBRT planning Open
View article: Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease
Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet’s Disease Open
We describe our experience with a juvenile patient who had refractory intestinal Behcet’s disease that responded to adalimumab, a fully humanized antibody against soluble TNF-and its receptor. The patient, a 13-year-old girl, presented wit…