Takayuki Kitahara
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View article: Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting
Development of a novel rat long-bone nonunion model and efficacy evaluation of a prostaglandin EP4 selective agonist (AKDS001) combined with iliac bone grafting Open
Aims Nonunion occurs when a fracture fails to heal permanently, often necessitating surgical intervention to stimulate the bone healing response. Current animal models of long-bone nonunion do not adequately replicate human pathological co…
View article: Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone Open
Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack o…
View article: Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion
Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion Open
View article: rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model
rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model Open
Background Nonunion following fracture treatment remains a significant clinical challenge, adversely affecting the patient’s quality of life and imposing a substantial economic burden. The emergence of bone morphogenetic protein 2 (BMP-2) …
View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the Article Cellular senescence by loss of Men1 in osteoblasts is critical for age‐related osteoporosis by Yuichiro Ukon et al., https://doi.org/10.1111/acel.14254 [Image: see text]
View article: Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosis
Cellular senescence by loss of <i>Men1</i> in osteoblasts is critical for age‐related osteoporosis Open
Recent evidence suggests an association between age‐related osteoporosis and cellular senescence in the bone; however, the specific bone cells that play a critical role in age‐related osteoporosis and the mechanism remain unknown. Results …
View article: Appropriate pelvic obliquity measurement method in Lenke type 5C adolescent idiopathic scoliosis: a preliminary study
Appropriate pelvic obliquity measurement method in Lenke type 5C adolescent idiopathic scoliosis: a preliminary study Open
Given the asymmetric sacral morphology, SO is more appropriate pelvic parameter than IO to represent the sacral tilt of Lenke 5C AIS, especially when measured using CT images to overcome the poor visibility on PA whole-spine radiographs.
View article: Identification of unapproved orthopedic regenerative medicine: Usefulness of the Act on Safety of Regenerative Medicine
Identification of unapproved orthopedic regenerative medicine: Usefulness of the Act on Safety of Regenerative Medicine Open
View article: A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model
A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model Open
View article: Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis
Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis Open
Recent evidence suggests an association between age-related osteoporosis and cellular senescence in the bone; however, the specific bone cells that play a critical role in age-related osteoporosis and the mechanism remain unknown. Results …
View article: Review of Basic Research about Ossification of the Spinal Ligaments Focusing on Animal Models
Review of Basic Research about Ossification of the Spinal Ligaments Focusing on Animal Models Open
Ossification of the posterior longitudinal ligament (OPLL) is a heterotopic ossification that may cause spinal cord compression. With the recent development of computed tomography (CT) imaging, it is known that patients with OPLL often hav…