Takayuki Miyazawa
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View article: Establishment of a Chikungunya virus pseudotype system strictly dependent on viral protein expression
Establishment of a Chikungunya virus pseudotype system strictly dependent on viral protein expression Open
Chikungunya virus (CHIKV) is an enveloped RNA virus that causes Chikungunya fever in humans. It is classified as an arbovirus (arthropod-borne virus) and is transmitted by mosquitoes. Therefore, CHIKV can replicate in many types of cells d…
View article: Significant Increase in Excess Deaths after Repeated COVID-19 Vaccination in Japan
Significant Increase in Excess Deaths after Repeated COVID-19 Vaccination in Japan Open
Although Japan recorded the world's highest rate of COVID-19 messenger ribonucleic acid (mRNA) vaccination doses per capita, COVID-19 cases and deaths exploded after the emergence of the Omicron variant, followed by a significant increase …
View article: Establishment of a Chikungunya virus pseudotype system strictly dependent on viral protein expression
Establishment of a Chikungunya virus pseudotype system strictly dependent on viral protein expression Open
Chikungunya virus (CHIKV) is an enveloped RNA virus that causes Chikungunya fever in humans. It is classified into the arboviruses (arthropod-borne viruses) and is transmitted by mosquitoes. Therefore, mosquitoes can replicate many types o…
View article: Association between endoscopic evidence of bile reflux and Barrett's esophagus: A large-scale case-control study
Association between endoscopic evidence of bile reflux and Barrett's esophagus: A large-scale case-control study Open
View article: Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection
Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection Open
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly caused pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evolutionary…
View article: Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection
Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection Open
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly caused pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evolutionary…
View article: Raw data for "Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection"
Raw data for "Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection" Open
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly caused pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evolutionary…
View article: Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection
Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection Open
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly caused pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evolutionary…
View article: Unnaturalness in the evolution process of the SARS-CoV-2 variants and the possibility of deliberate natural selection
Unnaturalness in the evolution process of the SARS-CoV-2 variants and the possibility of deliberate natural selection Open
Over the past three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly experienced pandemics, generating various mutated variants ranging from Alpha to Omicron. In this study, we aimed to clarify the evoluti…
View article: Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes
Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes Open
Independently acquired envelope (env) genes from endogenous retroviruses have contributed to the placental trophoblast cell–cell fusion in therian mammals. Egg-laying mammals (monotremes) are an important sister clade for understanding mam…
View article: Potentially reduced fusogenicity of syncytin‐2 in New World monkeys
Potentially reduced fusogenicity of syncytin‐2 in New World monkeys Open
Syncytin‐2 is a membrane fusion protein involved in placenta development that is derived from the endogenous retrovirus envelope gene acquired in the common ancestral lineage of New World and Old World monkeys (OWMs). It is known that sync…
View article: Characterization of ferret Pit1 as a receptor of feline leukemia virus subgroup B
Characterization of ferret Pit1 as a receptor of feline leukemia virus subgroup B Open
Feline leukemia virus (FeLV) is a retrovirus that causes immune suppression and immunodeficiency, leading to opportunistic infections and leukemia/lymphoma in cats. Today, a variety of domestic mammals are kept in houses, and it is importa…
View article: Management of Rare Hemorrhage From Collateral Vessels During Gastrostomy Replacement Using Percutaneous Transhepatic Occlusion in Patient With Portal Hypertension
Management of Rare Hemorrhage From Collateral Vessels During Gastrostomy Replacement Using Percutaneous Transhepatic Occlusion in Patient With Portal Hypertension Open
A 51-year-old male patient with alcoholic cirrhosis visited our hospital for a scheduled gastrostomy replacement. During the gastrostomy replacement, he suddenly experienced a massive hemorrhage from the fistula site. Based on enhanced com…
View article: A STUDY ON THE ATTITUDES OF FIELD PHYSICIANS TOWARD COVID-19 PREVENTION MEASURES
A STUDY ON THE ATTITUDES OF FIELD PHYSICIANS TOWARD COVID-19 PREVENTION MEASURES Open
COVID-19の感染拡大を踏まえ,度重なる緊急事態宣言が発令されたのにも関わらず,医療体制の緊迫,そして過度な自粛による経済の後退や社交の減少などの問題が存在する.また,COVID-19の危険性やワクチンの接種に対する正しい認識は広まっておらず,医療関係者の意見より,政府の見解や社会の空気が世論に大きく影響しているのが現状である.そこで本論文は,大阪府の医師に対しアンケート調査を実施し,236名分の回答から,COVID-19対応の医療現場にあるべき行政支援策,COVID-…
View article: Dynamic evolution of retroviral envelope genes in egg-laying mammalian genomes
Dynamic evolution of retroviral envelope genes in egg-laying mammalian genomes Open
Independently acquired envelope ( env ) genes from endogenous retroviruses have contributed to the placental trophoblast cell-cell fusion in therian mammals. Egg-laying mammals (monotremes) are an important sister clade for understanding m…
View article: Endogenous Retroviruses and Placental Evolution, Development, and Diversity
Endogenous Retroviruses and Placental Evolution, Development, and Diversity Open
The main roles of placentas include physical protection, nutrient and oxygen import, export of gasses and fetal waste products, and endocrinological regulation. In addition to physical protection of the fetus, the placentas must provide im…
View article: Monotreme-specific conserved putative proteins derived from retroviral reverse transcriptase
Monotreme-specific conserved putative proteins derived from retroviral reverse transcriptase Open
Endogenous retroviruses (ERVs) have played an essential role in the evolution of mammals. ERV-derived genes are reported in the therians, many of which are involved in placental development; however, the contribution of the ERV-derived gen…
View article: Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology
Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology Open
Endogenous retroviruses (ERVs) are retroviral sequences present in the host genomes. Although most ERVs are inactivated, some are produced as replication-competent viruses from host cells. We previously reported that several live-attenuate…
View article: Monotreme-specific conserved proteins derived from retroviral reverse transcriptase
Monotreme-specific conserved proteins derived from retroviral reverse transcriptase Open
Endogenous retroviruses (ERVs) have played an essential role in the evolution of mammals. Many ERV-derived genes are reported in the therians that are involved in placental development. However, the contribution of the ERV-derived genes in…
View article: Genetic and biological characterization of feline foamy virus isolated from a leopard cat (<i>Prionailurus bengalensis</i>) in Vietnam
Genetic and biological characterization of feline foamy virus isolated from a leopard cat (<i>Prionailurus bengalensis</i>) in Vietnam Open
Foamy viruses have been isolated from various mammals and show long-term co-speciation with their hosts. However, the frequent inter-species transmission of feline foamy viruses (FFVs) from domestic cats to wild cats across genera has been…
View article: Systematic Identification of Endogenous Retroviral Protein-Coding Genes Expressed in Canine Oral Malignant Melanoma
Systematic Identification of Endogenous Retroviral Protein-Coding Genes Expressed in Canine Oral Malignant Melanoma Open
Endogenous retroviruses (ERVs) are remnants of ancestral retroviruses that infected host germ cells in the past. Most ERVs are thought to be non-functional elements, but some ERVs retain open reading frames (ORFs) capable of expressing pro…
View article: An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Background Retroviruses utilize multiple unique RNA elements to control RNA processing and translation. However, it is unclear what functional RNA elements are present in endogenous retroviruses (ERVs). Gene co-option from ERVs sometimes e…
View article: Molecular Epidemiology and Whole-Genome Analysis of Bovine Foamy Virus in Japan
Molecular Epidemiology and Whole-Genome Analysis of Bovine Foamy Virus in Japan Open
Bovine foamy virus (BFV) is a member of the foamy virus family in cattle. Information on the epidemiology, transmission routes, and whole-genome sequences of BFV is still limited. To understand the characteristics of BFV, this study includ…
View article: An ancient retroviral RNA element hidden in mammalian genomes and its involvement in coopted retroviral gene regulation
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in coopted retroviral gene regulation Open
Retroviruses utilize multiple unique RNA elements to control several aspects of RNA processing, such as splicing, subcellular export, and translation. However, it is mostly unclear whether such functional RNA elements are present in endoge…
View article: Additional file 8 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 8 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 8: Table S3. The numbers of SPRE-like elements in avian genomes.
View article: Additional file 7 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 7 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 7: Table S2. The numbers of SPRE-like elements in mammalian genomes.
View article: Additional file 11 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 11 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 11: Table S6. Accession numbers used for phylogenetic tree of syncytin genes.
View article: Additional file 6 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 6 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 6: Table S1. Dram families harboring SPRE-like elements and their annotations.
View article: Additional file 9 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 9 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 9: Table S4. RepeatMasker versions and referenced databases.
View article: Additional file 10 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Additional file 10 of An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation Open
Additional file 10: Table S5. Primers used in this study.